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Citation: 'drug repurposing' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12648 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Ravichandran Veerasamy +3 more
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Drug Repurposing in the Treatment of COVID-19
, 2020 The use of drugs that have been previously defined for certain indications in new indications is defined as the repurposing/repositioning of the drug. The requirement of all clinical research steps that starts from healthy volunteers, due to the slowness
Yetik Anacak, Gunay +5 more
core +1 more source
Activity profile of an FDA-approved compound library against Schistosoma mansoni [PDF]
, 2015 As plans to expand mass drug treatment campaigns to fight schistosomiasis form, worries about reliance on praziquantel as the sole available treatment motivate the investigation for novel antischistosomal compounds.
Gordana Panic +19 more
core +2 more sources
Repurposing – second life for drugs [PDF]
Pharmacia, 2022 Drug repurposing refers to finding new indications for existing drugs. The paradigm shift from traditional drug discovery to drug repurposing is driven by the fact that new drug pipelines are getting dried up because of mounting Research & ...
Porkodi Ayyar, Umamaheswari Subramanian
doaj +3 more sources
Drug reprofiling history and potential therapies against Parkinson’s disease
Frontiers in Pharmacology, 2022 Given the high whittling down rates, high costs, and moderate pace of new medication, revelation, and improvement, repurposing “old” drugs to treat typical and uncommon illnesses is progressively becoming an appealing proposition. Drug repurposing is the
Komal Latif +10 more
doaj +1 more source
, 2023 The identification of new therapeutic uses for compounds via computational or experimental approaches, which is widely known as drug repurposing, has the potential to develop novel therapies with pre-existing medicines, thereby reducing the time and ...
Pan, L +4 more
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A machine learning and network framework to discover new indications for small molecules.
PLoS Computational Biology, 2020 Drug repurposing, identifying novel indications for drugs, bypasses common drug development pitfalls to ultimately deliver therapies to patients faster. However, most repurposing discoveries have been led by anecdotal observations (e.g.
Coryandar Gilvary +5 more
doaj +1 more source
Old Drugs, New Indications (Review)
Разработка и регистрация лекарственных средств, 2023 Introduction. The drug can be used in the treatment of one disease and for the prevention and treatment of another pathological process. This is possible due to the repurposing of medicines.
I. I. Miroshnichenko +2 more
doaj +1 more source
In-Silico Drug Repurposing for Targeting SARS-CoV-2 Mpro [PDF]
, 2020 COVID-19, caused by novel coronavirus or SARS-CoV-2, is a viral disease which has infected millions worldwide. Considering the urgent need of the drug for fighting against this infectious disease, we performed in-silico drug repurposing.
Shilpa, Sharma, Shashank, Deep
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The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source