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Citation: 'drug repurposing' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12648 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Ravichandran Veerasamy +3 more
+7 more sources
Drug reprofiling history and potential therapies against Parkinson’s disease
Frontiers in Pharmacology, 2022 Given the high whittling down rates, high costs, and moderate pace of new medication, revelation, and improvement, repurposing “old” drugs to treat typical and uncommon illnesses is progressively becoming an appealing proposition. Drug repurposing is the
Komal Latif +10 more
doaj +1 more source
Repurposing – second life for drugs [PDF]
Pharmacia, 2022 Drug repurposing refers to finding new indications for existing drugs. The paradigm shift from traditional drug discovery to drug repurposing is driven by the fact that new drug pipelines are getting dried up because of mounting Research & ...
Porkodi Ayyar, Umamaheswari Subramanian
doaj +3 more sources
In-Silico Drug Repurposing for Targeting SARS-CoV-2 Mpro [PDF]
, 2020 COVID-19, caused by novel coronavirus or SARS-CoV-2, is a viral disease which has infected millions worldwide. Considering the urgent need of the drug for fighting against this infectious disease, we performed in-silico drug repurposing.
Shilpa, Sharma, Shashank, Deep
core +2 more sources
A machine learning and network framework to discover new indications for small molecules.
PLoS Computational Biology, 2020 Drug repurposing, identifying novel indications for drugs, bypasses common drug development pitfalls to ultimately deliver therapies to patients faster. However, most repurposing discoveries have been led by anecdotal observations (e.g.
Coryandar Gilvary +5 more
doaj +1 more source
Drug Repurposing for Rare Orphan Diseases Using Machine Learning Techniques
Proceedings of the International Florida Artificial Intelligence Research Society Conference, 2022 New drug discovery is a time-consuming and costly process. Several drugs have been in clinical trials for a very long period. Finding a new target for existing medications can be an effective strategy to reduce the lengthy and costly drug development ...
Rajesh Manicavasaga +3 more
doaj +1 more source
Preprint: A drug repurposing screen for whipworms informed by comparative genomics
, 2023 Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy.
Avril Coghlan +14 more
core +1 more source
Old Drugs, New Indications (Review)
Разработка и регистрация лекарственных средств, 2023 Introduction. The drug can be used in the treatment of one disease and for the prevention and treatment of another pathological process. This is possible due to the repurposing of medicines.
I. I. Miroshnichenko +2 more
doaj +1 more source
Multitarget Virtual Screening for Drug Repurposing in COVID19 [PDF]
, 2020 Therapeutic or preventive research for coronavirus SARS-CoV2 is an extremely active topic of research since its outbreak in January 2020. In this paper we report the results from a virtual drug screening analysis that, to the best of our knowledge, is ...
carlos oscar, Sorzano +3 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source