Results 51 to 60 of about 45,299 (154)

Has the human biological interaction with SARS‐CoV2 variants entered a pliant “Faustian bargain”?

Pharmacology Research & Perspectives
We hypothesize that a “Faustian bargain”—the trading of increased SARS—CoV2 viral infection with a concurrent potential for prevention of life‐threatening lower lung infection explains the previous and future morbidity and mortality from COVID‐19 ...
Richard J. Head, Marko Popovic, Jennifer H. Martin   +2 more
doaj   +1 more source

Study on Drug Repurposing for ALS Treatment Using Pre-trained Knowledge Graph Embeddings: Methods and Findings

Düzce Üniversitesi Bilim ve Teknoloji Dergisi
In this study, research has been conducted using pre-trained knowledge graph embedding for drug repurposing in treating ALS (Amyotrophic Lateral Sclerosis), and its results have been presented.
Selcan Yalkızımı, Ümit Şentürk
doaj   +1 more source

Research and analysis of regulatory framework and harmonisation of repurposing [PDF]

Pharmacia
Drug repurposing is a modern and successful mechanism for discovering new therapeutic indications for authorised medicinal products. There is an absence of a clear definition of the term “drug repurposing” or its synonyms in regulatory frameworks, which ...
Antonio Ivanov, Violeta Getova-Kolarova, Ilko Getov   +2 more
doaj   +3 more sources

Advancing the human right to health in cancer care through drug repurposing strategies

International Journal for Equity in Health
This perspective critically evaluates the global potential of drug repurposing strategies in oncology to advance health equity and sustainable innovation.
Nahida Sakis, Michelle Slone, Nadav Michaan, Shamgar Ben-Eliyahu   +3 more
doaj   +1 more source

International regulatory and publicly-funded initiatives to advance drug repurposing

Frontiers in Medicine
IntroductionAlthough drug repurposing holds great potential in addressing unmet needs, successful practical implementation is challenging and has been less widespread than anticipated.
Eva Louise Spin, Aukje K. Mantel-Teeuwisse, Anna Maria Gerdina Pasmooij, Anna Maria Gerdina Pasmooij   +3 more
doaj   +1 more source

Drug repurposing for cancer therapy

Signal Transduction and Targeted Therapy
AbstractCancer, a complex and multifactorial disease, presents a significant challenge to global health. Despite significant advances in surgical, radiotherapeutic and immunological approaches, which have improved cancer treatment outcomes, drug therapy continues to serve as a key therapeutic strategy.
Ying Xia, Ming Sun, Hai Huang, Wei-Lin Jin   +3 more
openaire   +3 more sources

Open-source approaches for the repurposing of existing or failed candidate drugs: learning from and applying the lessons across diseases

Drug Design, Development and Therapy, 2013
Minna Allarakhia Department of Management Sciences, University of Waterloo, Waterloo, ON, Canada Abstract: Repurposing has the objective of targeting existing drugs and failed, abandoned, or yet-to-be-pursued clinical candidates to new disease areas. The
Allarakhia M
doaj  

Fusobacterium nucleatum: An Overview of Evidence, Demi-Decadal Trends, and Its Role in Adverse Pregnancy Outcomes and Various Gynecological Diseases, including Cancers

Cells
Gynecological and obstetric infectious diseases are crucial to women’s health. There is growing evidence that links the presence of Fusobacterium nucleatum (F. nucleatum), an anaerobic oral commensal and potential periodontal pathogen, to the development
Arunita Ghosh, Ken Jaaback, Angela Boulton, Michelle Wong-Brown, Steve Raymond, Partha Dutta, Nikola A. Bowden, Arnab Ghosh   +7 more
doaj   +1 more source

How drug repurposing can advance drug discovery: challenges and opportunities

Frontiers in Drug Discovery
Traditional de novo drug discovery, which typically presents an 11% approval rate from phase I trials and even higher failure rates in fields like neurodegeneration, often requires two to three billion dollars and 10–17 years per new drug.
Luca Pinzi, Nicolò Bisi, Giulio Rastelli   +2 more
doaj   +1 more source

Transcriptomics- and Genomics-Guided Drug Repurposing for the Treatment of Vesicular Hand Eczema

Pharmaceutics
Vesicular hand eczema (VHE), a clinical subtype of hand eczema (HE), showed limited responsiveness to alitretinoin, the only approved systemic treatment for severe chronic HE. This emphasizes the need for alternative treatment approaches.
Fieke M. Rosenberg, Zoha Kamali, Angelique N. Voorberg, Thijs H. Oude Munnink, Peter J. van der Most, Harold Snieder, Ahmad Vaez, Marie L. A. Schuttelaar   +7 more
doaj   +1 more source