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Pharmacogenomics and Drug Development [PDF]

Pharmacogenomics, 2005
It is generally anticipated that pharmacogenomic information will have a large impact on drug development and will facilitate individualized drug treatment. However, there has been relatively little quantitative modeling to assess how pharmacogenomic information could be best utilized in clinical practice.
Yingying, Guo, Steven, Shafer, Paul, Weller, Jonathan, Usuka, Gary, Peltz   +4 more
openaire   +2 more sources

The role of microglial P2X7: modulation of cell death and cytokine release

Journal of Neuroinflammation, 2017
Background ATP-gated P2X7 is a non-selective cation channel, which participates in a wide range of cellular functions as well as pathophysiological processes including neuropathic pain, immune response, and neuroinflammation.
Yingbo He, Natalie Taylor, Lawrence Fourgeaud, Anindya Bhattacharya   +3 more
doaj   +1 more source

Randomized clinical trial to assess the protective efficacy of a Plasmodium vivax CS synthetic vaccine

Nature Communications, 2022
In this phase 2 clinical trial, the authors assess protective efficacy of a Plasmodium vivax circumsporozoite vaccine in naïve and semi-immune individuals from controlled human malaria infection as well as antibody and IFN-γ response to vaccination.
Myriam Arévalo-Herrera, Xiomara Gaitán, Michelle Larmat-Delgado, María Alejandra Caicedo, Sonia M. Herrera, Juliana Henao-Giraldo, Angélica Castellanos, Jean-Christophe Devaud, André Pannatier, José Oñate, Giampietro Corradin, Sócrates Herrera   +11 more
doaj   +1 more source

Herbomineral Medicine Peedanil Gold Exerts Analgesia in Neuropathy by Moderating Inflammatory Response and TRP Channel Expression in Sprague Dawley Rat Surgical Chronic Constriction Injury Model

Pain Research and Management
Conclusions: Altogether, the outcomes from the current study prove that PN-G is an effective antineuropathic agent with potential to manage pain as well as eliminate the underlying cause of neuroinflammation behind the chronicity of neuropathic pain.
Acharya Balkrishna, Shadrak Karumuri, Sandeep Sinha, Rani Singh, Rishabh Dev, Swati Haldar, Anurag Varshney   +6 more
doaj   +1 more source

Germi-X herbal-based spray disinfects smartphone surfaces: implication on fomite-mediated infection spread

AMB Express, 2022
Inanimate objects/surfaces become fomites upon contacting infectious agents such as disease-causing bacteria, fungi and viruses. Smartphones are one of the most prominent among these fomites.
Acharya Balkrishna, Kanchan Singh, Swati Haldar, Anurag Varshney   +3 more
doaj   +1 more source

Withania somnifera (L.) Dunal whole-plant extract demonstrates acceptable non-clinical safety in rat 28-day subacute toxicity evaluation under GLP-compliance

Scientific Reports, 2022
Withania somnifera (L.) Dunal (Ashwagandha) is widely used in Ayurveda, Unani and Siddha systems of medicines due to its therapeutic application in numerous ailments.
Acharya Balkrishna, Sandeep Sinha, Jyotish Srivastava, Anurag Varshney   +3 more
doaj   +1 more source

Pharmacoproteomics in drug development [PDF]

The Pharmacogenomics Journal, 2003
The field of proteomics is taking on increased significance as the relevance of investigating and understanding protein expression in disease and drug development is appreciated. Recent advances in proteomics have been driven by the availability of numerous annotated whole-genome sequences and a broad range of technological and bioinformatic ...
Frank A, Witzmann, Raymond A, Grant
openaire   +2 more sources

Herbo-mineral formulation ‘Ashwashila’ attenuates rheumatoid arthritis symptoms in collagen-antibody-induced arthritis (CAIA) mice model

Scientific Reports, 2019
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that affects joints of hands and feet and introduces injury in secondary organs such as cardiac tissue.
Acharya Balkrishna, Sachin Shridhar Sakat, Kheemraj Joshi, Sandeep Paudel, Deepika Joshi, Kamal Joshi, Ravikant Ranjan, Abhishek Gupta, Kunal Bhattacharya, Anurag Varshney   +9 more
doaj   +1 more source

Nonclinical Safety Evaluation of Renogrit: In Vitro Nonmutagenicity (OECD 471) and 28-Day Repeated Oral Dose Toxicity (OECD 407) in Sprague Dawley Rats

Journal of Toxicology
Renogrit is a prescription medicine developed by employing the traditional knowledge of Ayurveda for the management of kidney disorders. To support its extensive clinical investigations, Renogrit requires robust nonclinical safety assessments ...
Acharya Balkrishna, Aakanksha Tiwari, Himanshu Jangid, Kamaraj Mani, Savita Lochab, Sandeep Sinha, Anurag Varshney   +6 more
doaj   +1 more source

Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease

BMC Cancer, 2020
Background Malignant pleural mesothelioma (MPM) is traditionally characterized by local destructive spread of the pleura and surrounding tissues. Patient outcomes in MPM with distant metastatic dissemination are lacking.
Dearbhaile Catherine Collins, Raghav Sundar, Anastasia Constantidinou, David Dolling, Timothy Anthony Yap, Sanjay Popat, Mary E. O’Brien, Udai Banerji, Johann Sebastian de Bono, Juanita Suzanne Lopez, Nina Tunariu, Anna Minchom   +11 more
doaj   +1 more source