Results 11 to 20 of about 2,250,283 (269)
Drugs in Development for Malaria [PDF]
Drugs, 2018 The last two decades have seen a surge in antimalarial drug development with product development partnerships taking a leading role. Resistance of Plasmodium falciparum to the artemisinin derivatives, piperaquine and mefloquine in Southeast Asia means new antimalarials are needed with some urgency.
Ashley, E, Phyo, A
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Developing Drugs For Developing Countries [PDF]
Health Affairs, 2006 Infectious and parasitic diseases create enormous health burdens, but because most of the people suffering from these diseases are poor, little is invested in developing treatments. We propose that developers of treatments for neglected diseases receive a "priority review voucher." The voucher could save an average of one year of U.S.
David B, Ridley +2 more
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Drug resistance and antiretroviral drug development [PDF]
Journal of Antimicrobial Chemotherapy, 2005 As more drugs for treating HIV have become available, drug resistance profiles within antiretroviral drug classes have become increasingly important for researchers developing new drugs and for clinicians integrating new drugs into their clinical practice. In vitro passage experiments and comprehensive phenotypic susceptibility testing are used for the
Robert W, Shafer, Jonathan M, Schapiro
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Drug Development: Stages of Drug Development [PDF]
Journal of Pharmacovigilance, 2015 New drug development program for the different compound is initiated because there is a disease or clinical condition without suitable pharmacotherapeutic products available. New drug development can proceed along varied pathways for different compounds.
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Cytomics and drug development [PDF]
Cytometry Part A, 2007 Drug discovery is fundamentally focused on increasing the number and novelty of medicines, while containing the associated costs. High costs impact on healthcare delivery and the range of diseases for which medicines become available. Pace has been increased via combinatorial chemistry, genomics knowledge, proteomics technologies, new target validation
Paul J, Smith, I A, Khan, R J, Errington
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Drug development, radiolabeled drugs and PET
Annals of Medicine, 1999 Positron emission tomography (PET) provides noninvasive in vivo quantitative pharmacokinetic and pharmacodynamic information on novel and established drugs. Because only very low amounts of the (potential) drug have to be administered, far below toxicity levels, human studies can be carried out even before the drug is entered in phase I studies.
Vaalburg, W +2 more
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, 2007 openAccessArticle: False ; cover date: 2015-01-01 ; pii: B978-0-12-801238-3.04980-1 ; Harvest Date: 2016-01-06 13:08:13 ; issueName: ; Page Range: - ; href scidir: http://www.sciencedirect.com/science/article/pii/B9780128012383049801 ; pubType:
L., Wecker, Wecker, L., Krzanowski, J.
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BMC Cancer, 2021 An amendment to this paper has been published and can be accessed via the original article.
Dearbhaile Catherine Collins +11 more
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Pharmacology Research & Perspectives, 2023 The importance of vesicular monoamine transporter 2 (VMAT2) in dopamine regulation, which is considered crucial for neuropsychiatric disorders, is currently being studied.
Heejin Lee +14 more
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Drug metabolism in drug discovery and development
Acta Pharmaceutica Sinica B, 2018 Drug metabolism as a discipline plays an important role in drug discovery and development and the effects of drug metabolism on pharmacokinetics (PK), pharmacodynamics (PD), and safety should be carefully considered. This communication provides an overview of common strategies in the area of drug metabolism for improving PK/PD and safety profiles of ...
Zhoupeng Zhang, Wei Tang
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