Results 11 to 20 of about 2,491,987 (318)
Trials, 2023 The COVID-19 pandemic has had an unprecedented and disruptive impact on people’s health and lives worldwide. In addition to burdening people’s health in the short-term in the form of infection, illness, and mortality, there has been an enormous negative ...
Kelsey McDonald +6 more
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Communications Biology, 2021 Yen et al use tissue-specific PP2A knockout mice to show that PP2A in LepR positive mesenchymal stem cells positively regulates endochondral ossification. They find that PP2A dephosphorylates Runx2 and BRD4, thereby playing a major role in positively and
Yu-Ting Yen +3 more
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Drugs in Development for Malaria [PDF]
Drugs, 2018 The last two decades have seen a surge in antimalarial drug development with product development partnerships taking a leading role. Resistance of Plasmodium falciparum to the artemisinin derivatives, piperaquine and mefloquine in Southeast Asia means new antimalarials are needed with some urgency.
Ashley, E, Phyo, A
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BMC Medical Research Methodology, 2022 Background Missing data may lead to loss of statistical power and introduce bias in clinical trials. The Covid-19 pandemic has had a profound impact on patient health care and on the conduct of cancer clinical trials.
Corinne Jamoul +6 more
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Developing Drugs For Developing Countries [PDF]
Health Affairs, 2006 Infectious and parasitic diseases create enormous health burdens, but because most of the people suffering from these diseases are poor, little is invested in developing treatments. We propose that developers of treatments for neglected diseases receive a "priority review voucher." The voucher could save an average of one year of U.S.
David B, Ridley +2 more
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Drug resistance and antiretroviral drug development [PDF]
Journal of Antimicrobial Chemotherapy, 2005 As more drugs for treating HIV have become available, drug resistance profiles within antiretroviral drug classes have become increasingly important for researchers developing new drugs and for clinicians integrating new drugs into their clinical practice. In vitro passage experiments and comprehensive phenotypic susceptibility testing are used for the
Robert W, Shafer, Jonathan M, Schapiro
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PPAR Research, 2021 According to the Center for Disease Control and Prevention (CDC), the coronavirus disease 2019, a respiratory viral illness linked to significant morbidity, mortality, production loss, and severe economic depression, was the third-largest cause of death ...
Mahdi Ftouh +5 more
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Nature Communications, 2021 Microsatellite instability (MSI), caused by deficiency of the DNA mismatch repair system, has been associated with improved response to immune checkpoint blockade (ICB).
Yu-Ting Yen +9 more
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Conversion of Aquaculture Waste into Biomedical Wealth: Chitin and Chitosan Journey
Advances in Materials Science and Engineering, 2022 Biowaste originating from aquaculture sector represents a potential feedstock to produce value-added substances and materials like chitin and chitosan. They are the long chain polymers of N-acetylglucosamine polymers with huge industrial and biomedical ...
Jerrine Joseph +8 more
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Drug Development in Tissue-Agnostic Indications
, 2021 A better understanding of cancer biology has led to the development of targeted therapies specifically designed to modulate an altered molecular pathway in the cancer cells or their microenvironment. Despite the identification of molecular targets across
Pauline du Rusquec +1 more
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