Results 31 to 40 of about 18,497,895 (269)

Nonclinical Safety Evaluation of Renogrit: In Vitro Nonmutagenicity (OECD 471) and 28-Day Repeated Oral Dose Toxicity (OECD 407) in Sprague Dawley Rats

Journal of Toxicology
Renogrit is a prescription medicine developed by employing the traditional knowledge of Ayurveda for the management of kidney disorders. To support its extensive clinical investigations, Renogrit requires robust nonclinical safety assessments ...
Acharya Balkrishna, Aakanksha Tiwari, Himanshu Jangid, Kamaraj Mani, Savita Lochab, Sandeep Sinha, Anurag Varshney   +6 more
doaj   +1 more source

The role of microglial P2X7: modulation of cell death and cytokine release

Journal of Neuroinflammation, 2017
Background ATP-gated P2X7 is a non-selective cation channel, which participates in a wide range of cellular functions as well as pathophysiological processes including neuropathic pain, immune response, and neuroinflammation.
Yingbo He, Natalie Taylor, Lawrence Fourgeaud, Anindya Bhattacharya   +3 more
doaj   +1 more source

Withania somnifera (L.) Dunal whole-plant extract demonstrates acceptable non-clinical safety in rat 28-day subacute toxicity evaluation under GLP-compliance

Scientific Reports, 2022
Withania somnifera (L.) Dunal (Ashwagandha) is widely used in Ayurveda, Unani and Siddha systems of medicines due to its therapeutic application in numerous ailments.
Acharya Balkrishna, Sandeep Sinha, Jyotish Srivastava, Anurag Varshney   +3 more
doaj   +1 more source

Ewing Sarcoma in Infants and Children Under 2 Years of Age: A French Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ewing sarcoma, the second most common primary bone cancer in children, requires intensive treatment that may lead to significant long‐term sequelae, particularly in infants. We retrospectively analyzed data from 1621 French patients treated between 1988 and 2015 within the EW88/93/97 or EE99 trials, focusing on 17 infants diagnosed before 24 ...
Elodie Verdier, Nathalie Cozic, Marie‐Dominique Tabone, Gaelle Pierron, Perrine Marec‐Berard, Sarah Winter, Gabriel Revon‐Rivière, Cyril Lervat, Dominique Plantaz, Marie‐Pierre Castex, Gregory Guimard, Estelle Thebaud, Stephanie Proust, Laure Saumet, Natacha Entz‐Werle, Sophie Taque, Cécile Vérité, Marta Jimenez, Nathalie Gaspar   +18 more
wiley   +1 more source

Herbo-Mineral Medicine, Cardiogrit Gold, Exhibits Protective Effects in Caenorhabditis elegans Model of Doxorubicin-Induced Cardiotoxicity

Journal of Toxicology
Doxorubicin, an effective antineoplastic agent, is often prescribed for the treatment of various carcinomas. However, the use of doxorubicin becomes limited due to its adverse effects like cardiotoxicity, dysmenorrhea, and leucopenia. Cardiogrit Gold (CG)
Acharya Balkrishna, Saurabh Bhatti, Meenu Tomer, Sudeep Verma, Rishabh Dev, Anurag Varshney   +5 more
doaj   +1 more source

Provider and Parent Perspectives on Prioritizing the “Asking and Monitoring” Pediatric Cancer Psychosocial Standards of Care

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families (“Standards”) are evidence‐based guidelines for psychosocial care in pediatric oncology. Care related to the three “Asking and Monitoring” Standards—Assessment of Psychosocial Needs, Assessment of Financial Needs, and Monitoring Neurocognitive Problems ...
Julia B. Tager, Natalie Koskela‐Staples, Emily M. Pariseau, Michele Scialla, Kimberly Buff, Lori Wiener, Victoria Sardi Brown, Anne E. Kazak, Kimberly S. Canter   +8 more
wiley   +1 more source

Nonclinical Safety Evaluation of Nonmutagenic Immunogrit Following Subacute 28-Day Repeated Dose Oral Toxicity in Sprague–Dawley Rats With GLP Compliance

Journal of Toxicology
Immunogrit is a traditional Ayurvedic medicine prescribed to patients for their general well-being. In this study, Immunogrit was evaluated for its subacute (28 days) repeated oral dose toxicity in male and female Sprague-Dawley (SD) rats of similar age ...
Acharya Balkrishna, Kunal Bhattacharya, Sudeep Verma, Himanshu Jangid, Savita Lochab, Anurag Varshney   +5 more
doaj   +1 more source

Herbo-mineral formulation ‘Ashwashila’ attenuates rheumatoid arthritis symptoms in collagen-antibody-induced arthritis (CAIA) mice model

Scientific Reports, 2019
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that affects joints of hands and feet and introduces injury in secondary organs such as cardiac tissue.
Acharya Balkrishna, Sachin Shridhar Sakat, Kheemraj Joshi, Sandeep Paudel, Deepika Joshi, Kamal Joshi, Ravikant Ranjan, Abhishek Gupta, Kunal Bhattacharya, Anurag Varshney   +9 more
doaj   +1 more source

Germi-X herbal-based spray disinfects smartphone surfaces: implication on fomite-mediated infection spread

AMB Express, 2022
Inanimate objects/surfaces become fomites upon contacting infectious agents such as disease-causing bacteria, fungi and viruses. Smartphones are one of the most prominent among these fomites.
Acharya Balkrishna, Kanchan Singh, Swati Haldar, Anurag Varshney   +3 more
doaj   +1 more source

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source