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How drug repurposing can advance drug discovery: challenges and opportunities [PDF]

Frontiers in Drug Discovery
Traditional de novo drug discovery, which typically presents an 11% approval rate from phase I trials and even higher failure rates in fields like neurodegeneration, often requires two to three billion dollars and 10–17 years per new drug.
Luca Pinzi, Giulio Rastelli, Nicolò Bisi   +2 more
exaly   +4 more sources

Drug repurposing [PDF]

, 2022
Drug repurposing is the process of finding new therapeutic applications for previously used, available or older medications. Drug repurposing, refers to a set of approaches that aim to adapt the current pharmacological effects to new applications. Repurposing can help uncover new medicines for diseases at a low cost and in less time.
Dr Gyansagar Kushwaha, Dr. K Shrman, Dr. Chetna Sharma, Dr. Gayatri Singh   +3 more
core   +7 more sources

Drug Repurposing in Human Cancers

Current Medicinal Chemistry, 2020
Drug Repurposing in Human ...
Grassi G., Grassi M.
openaire   +4 more sources

Drug repurposing

Science, 2020
Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs.
openaire   +2 more sources

molIEreVIS: exploring and interpreting the evidence behind drug repurposing predictions [PDF]

Frontiers in Bioinformatics
IntroductionFinding new uses for existing drugs, known as drug repurposing, is a widely adopted drug development strategy in the pharmaceutical industry.
Amal Alnouri, Andreas Hinterreiter, Christian Steinparz, Labinot Bajraktari, Sebastian Burgstaller-Muehlbacher, Markus Bauer, Gregorio Alanis-Lobato, Marc Streit   +7 more
doaj   +2 more sources

DRQuantum: a drug repurposing method by quantum walks on a multi-layered heterogeneous network [PDF]

Scientific Reports
Traditional drug development poses significant financial and temporal costs, whereas drug repurposing emerges as a cost-effective and efficient alternative.
Zengjing Chen, Xin Guo, Hao Jiang, Zhiping Liu, Ziqi Lu   +4 more
doaj   +2 more sources

Drug Repurposing for Kala-Azar [PDF]

Pharmaceutics
Objective: Visceral leishmaniasis (VL), a Neglected Tropical Disease caused by Leishmania donovani, remains insufficiently addressed by current therapies due to high toxicity, poor efficacy, and immunosuppressive complications. This study aimed to identify and characterize repurposed drugs that simultaneously target parasite-encoded and host-associated
Biljana Arsić, Budimir S. Ilić, Andreas Maier, Michael Hartung, Jovana Janjić, Jelena Milićević, Jan Baumbach   +6 more
openaire   +6 more sources

Does collective consciousness compromise during epidemics and pandemics? [PDF]

EAI Endorsed Transactions on Smart Cities, 2021
The ongoing pandemic, COVID-19, has received unprecedented global attention. Though a pathogen is essentially the causative agent, the dynamics of the cause-effect in major events like the ongoing COVID-19 pandemic is not ...
Anoushka Khanna, Namita I, Rina Chakrabarti, Prem Indraganti   +3 more
doaj   +1 more source

Drug repurposing for cancer therapy

Signal Transduction and Targeted Therapy
AbstractCancer, a complex and multifactorial disease, presents a significant challenge to global health. Despite significant advances in surgical, radiotherapeutic and immunological approaches, which have improved cancer treatment outcomes, drug therapy continues to serve as a key therapeutic strategy.
Ying Xia, Ming Sun, Hai Huang, Wei-Lin Jin   +3 more
openaire   +4 more sources

ADVANCES AND DEVELOPMENTS IN DRUG REPURPOSING; STATE OF ART [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2023
Although the rapid progress in science and technology, developing new drugs from scratch has been expensive in recent decades. As a result, drug-repurposing, which implies seeking new utilizes for presently approved drugs instead of discovering new drug ...
Sarmad noori, Mais Al-Hamdani, Amira kassem   +2 more
doaj   +1 more source