Results 11 to 20 of about 45,299 (154)
Antifungal Drug Repurposing [PDF]
Antibiotics, 2020 Control of fungal pathogens is increasingly problematic due to the limited number of effective drugs available for antifungal therapy. Conventional antifungal drugs could also trigger human cytotoxicity associated with the kidneys and liver, including ...
Jong H. Kim +7 more
doaj +3 more sources
Editorial: Drug Repurposing [PDF]
Frontiers in Medicine, 2019 Pan Pantziarka +5 more
doaj +4 more sources
Repurposing Drugs via Network Analysis: Opportunities for Psychiatric Disorders
Pharmaceutics, 2022 Despite advances in pharmacology and neuroscience, the path to new medications for psychiatric disorders largely remains stagnated. Drug repurposing offers a more efficient pathway compared with de novo drug discovery with lower cost and less risk ...
Trang T. T. Truong +3 more
doaj +1 more source
A data-driven methodology towards evaluating the potential of drug repurposing hypotheses
Computational and Structural Biotechnology Journal, 2021 Drug repurposing has become a widely used strategy to accelerate the process of finding treatments. While classical de novo drug development involves high costs, risks, and time-consuming paths, drug repurposing allows to reuse already-existing and ...
Lucía Prieto Santamaría +5 more
doaj +1 more source
Drug Repurposing in Parkinson’s Disease [PDF]
CNS Drugs, 2018 The development of an intervention to slow or halt disease progression remains the greatest unmet therapeutic need in Parkinson's disease. Given the number of failures of various novel interventions in disease-modifying clinical trials in combination with the ever-increasing costs and lengthy processes for drug development, attention is being turned to
Athauda, D, Foltynie, T
openaire +3 more sources
Considerations and challenges for sex-aware drug repurposing
Biology of Sex Differences, 2022 Highlights Genetic, epigenetic, hormonal, immunological, metabolic, and environmental factors affect sex-biased drug responses. Drug repurposing approaches provide a significant advantage over novel drug development by reducing lengthy and costly ...
Jennifer L. Fisher +5 more
doaj +1 more source
Pharmaceutics, 2021 Drug repurposing is a valuable alternative to traditional drug design based on the assumption that medicines have multiple functions. Computer-based techniques use ever-growing drug databases to uncover new drug repurposing hints, which require further ...
Vlad Groza +3 more
doaj +1 more source
Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining [PDF]
Royal Society Open Science, 2018 Drug repurposing aims to find novel indications of clinically used or experimental drugs. Because drug data already exist, drug repurposing may save time and cost, and bypass safety concerns.
Tsang-Pai Liu +3 more
doaj +1 more source
Network Crosstalk as a Basis for Drug Repurposing
Frontiers in Genetics, 2022 The need for systematic drug repurposing has seen a steady increase over the past decade and may be particularly valuable to quickly remedy unexpected pandemics. The abundance of functional interaction data has allowed mapping of substantial parts of the
Dimitri Guala +2 more
doaj +1 more source
Buying time: Drug repurposing to treat the host in COVID‐19H
Pharmacology Research & Perspectives, 2020 In 2016 Fedson stated …. “For almost two decades, leading scientists and health officials have warned that we must prepare for a potentially devastating global pandemic of an infectious disease. Initial concern was focused on …H5N1….
Jennifer H. Martin +2 more
doaj +1 more source