Results 11 to 20 of about 45,859 (253)
Cells, 2022 Glioblastoma is a highly aggressive, invasive and treatment-resistant tumour. The DNA damage response (DDR) provides tumour cells with enhanced ability to activate cell cycle arrest and repair treatment-induced DNA damage.
Mathew Lozinski +6 more
doaj +1 more source
A Path to Real-World Evidence in Critical Care Using Open-Source Data Harmonization Tools
Critical Care Explorations, 2023 COVID-19 highlighted the need for use of real-world data (RWD) in critical care as a near real-time resource for clinical, research, and policy efforts.
Smith F. Heavner, PhD, RN +11 more
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BMC Cancer, 2022 Background Platinum chemoresistance results in high-grade serous ovarian cancer (HGSOC) disease recurrence. Recent treatment advances using checkpoint inhibitor immunotherapy has not benefited platinum-resistant HGSOC.
Michelle W. Wong-Brown +2 more
doaj +1 more source
Pharmacology Research & Perspectives, 2021 Trial data support an absence of an exposure–survival relationship for pembrolizumab. As these relationships remain unexamined in a real‐world setting, we determined them in metastatic melanoma prospectively in an observational study.
Vishal Navani +5 more
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Drug repurposing for Alzheimer’s disease from 2012–2022—a 10-year literature review
Frontiers in Pharmacology, 2023 Background: Alzheimer’s disease (AD) is a debilitating neurodegenerative condition with few treatment options available. Drug repurposing studies have sought to identify existing drugs that could be repositioned to treat AD; however, the effectiveness of
Monika E. Grabowska +4 more
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Repurposing Drugs via Network Analysis: Opportunities for Psychiatric Disorders
Pharmaceutics, 2022 Despite advances in pharmacology and neuroscience, the path to new medications for psychiatric disorders largely remains stagnated. Drug repurposing offers a more efficient pathway compared with de novo drug discovery with lower cost and less risk ...
Trang T. T. Truong +3 more
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A data-driven methodology towards evaluating the potential of drug repurposing hypotheses
Computational and Structural Biotechnology Journal, 2021 Drug repurposing has become a widely used strategy to accelerate the process of finding treatments. While classical de novo drug development involves high costs, risks, and time-consuming paths, drug repurposing allows to reuse already-existing and ...
Lucía Prieto Santamaría +5 more
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Drug Repurposing in Parkinson’s Disease [PDF]
CNS Drugs, 2018 The development of an intervention to slow or halt disease progression remains the greatest unmet therapeutic need in Parkinson's disease. Given the number of failures of various novel interventions in disease-modifying clinical trials in combination with the ever-increasing costs and lengthy processes for drug development, attention is being turned to
Athauda, D, Foltynie, T
openaire +3 more sources
Considerations and challenges for sex-aware drug repurposing
Biology of Sex Differences, 2022 Highlights Genetic, epigenetic, hormonal, immunological, metabolic, and environmental factors affect sex-biased drug responses. Drug repurposing approaches provide a significant advantage over novel drug development by reducing lengthy and costly ...
Jennifer L. Fisher +5 more
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Pharmaceutics, 2021 Drug repurposing is a valuable alternative to traditional drug design based on the assumption that medicines have multiple functions. Computer-based techniques use ever-growing drug databases to uncover new drug repurposing hints, which require further ...
Vlad Groza +3 more
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