Results 71 to 80 of about 60,427 (345)
Advanced Functional Materials, EarlyView.A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam +8 more
wiley +1 more source
A Review of Current In Silico Methods for Repositioning Drugs and Chemical Compounds
Frontiers in Oncology, 2021 Drug repositioning is a new way of applying the existing therapeutics to new disease indications. Due to the exorbitant cost and high failure rate in developing new drugs, the continued use of existing drugs for treatment, especially anti-tumor drugs ...
Binsheng He +5 more
doaj +1 more source
Representation learning of drug and disease terms for drug repositioning
, 2017 Drug repositioning (DR) refers to identification of novel indications for the approved drugs. The requirement of huge investment of time as well as money and risk of failure in clinical trials have led to surge in interest in drug repositioning.
Anand, Ashish, Manchanda, Sahil
core +1 more source
In Vitro Screening for Drug Repositioning [PDF]
SLAS Discovery, 2015 Drug repositioning or repurposing has received much coverage in the scientific literature in recent years and has been responsible for the generation of both new intellectual property and investigational new drug submissions. The literature indicates a significant trend toward the use of computational- or informatics-based methods for generating ...
Graeme F, Wilkinson, Kevin, Pritchard
openaire +2 more sources
Topological network measures for drug repositioning [PDF]
Briefings in Bioinformatics, 2020 Abstract Drug repositioning has received increased attention since the past decade as several blockbuster drugs have come out of repositioning. Computational approaches are significantly contributing to these efforts, of which, network-based methods play a key role.
Badkas, Apurva +2 more
openaire +3 more sources
Nanodiamond Quantum Sensors for Probing Free Radical Biology
Advanced Functional Materials, EarlyView.Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley +1 more source
Single injection dual phase CBCT technique ameliorates results of trans-arterial chemoembolization for hepatocellular cancer [PDF]
, 2017 Cone-beam CT (CBCT) application to the field of trans-arterial chemoembolization has been recently the focus of several researches. This imaging modality is performed with a rotation of the C-arm around the patient, without needs of patient repositioning.
Argirã², Renato +6 more
core +1 more source
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein [PDF]
, 2005 The regulation of differentiation is particularly important in microbial eukaryotes that inhabit multiple environments. The parasite Trypanosoma brucei is an extreme example of this, requiring exquisite gene regulation during transmission from mammals to
Hendriks, Edward F, Matthews, Keith R
core +1 more source
GREP: genome for REPositioning drugs
Bioinformatics, 2019 Abstract Summary Making use of accumulated genetic knowledge for clinical practice is our next goal in human genetics. Here we introduce GREP (Genome for REPositioning drugs), a standalone python software to quantify an enrichment of the user-defined set of genes in the target of clinical indication ...
Sakaue, Saori, Okada, Yukinori
openaire +2 more sources