Results 71 to 80 of about 1,936,479 (187)
iDrug: Integration of drug repositioning and drug-target prediction via cross-network embedding.
PLoS Computational Biology, 2020 Computational drug repositioning and drug-target prediction have become essential tasks in the early stage of drug discovery. In previous studies, these two tasks have often been considered separately.
Huiyuan Chen, Feixiong Cheng, Jing Li
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Antiretroviral Drug Repositioning for Glioblastoma
CancersOutcomes for glioblastoma (GBM) remain poor despite standard-of-care treatments including surgical resection, radiation, and chemotherapy. Intratumoral heterogeneity contributes to treatment resistance and poor prognosis, thus demanding novel therapeutic approaches.
Sarah R. Rivas +16 more
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New drugs are not enough‑drug repositioning in oncology: An update
International Journal of Oncology, 2020 Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that are already known for use treating other diseases. The advantages of this are that several important drug characteristics are already established (including efficacy, pharmacokinetics, pharmacodynamics and toxicity), making the process of research for a ...
Armando, Romina Gabriela +2 more
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Drug repositioning for enzyme modulator based on human metabolite-likeness
BMC Bioinformatics, 2017 Background Recently, the metabolite-likeness of the drug space has emerged and has opened a new possibility for exploring human metabolite-like candidates in drug discovery.
Yoon Hyeok Lee +4 more
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Changing Trends in Computational Drug Repositioning [PDF]
Pharmaceuticals, 2018 Maximizing the indications potential and revenue from drugs that are already marketed offers a new take on the famous mantra of the Nobel Prize-winning pharmacologist, Sir James Black, “The most fruitful basis for the discovery of a new drug is to start with an old drug”.
Jaswanth K. Yella +3 more
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Structure-based drug repositioning explains ibrutinib as VEGFR2 inhibitor.
PLoS ONE, 2020 Many drugs are promiscuous and bind to multiple targets. On the one hand, these targets may be linked to unwanted side effects, but on the other, they may achieve a combined desired effect (polypharmacology) or represent multiple diseases (drug ...
Melissa F Adasme +11 more
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Drug repositioning based on individual bi-random walks on a heterogeneous network
BMC Bioinformatics, 2019 Background Traditional drug research and development is high cost, time-consuming and risky. Computationally identifying new indications for existing drugs, referred as drug repositioning, greatly reduces the cost and attracts ever-increasing research ...
Yuehui Wang +4 more
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Drug Repurposing in the Treatment of COVID-19
Bezmiâlem Science, 2020 The use of drugs that have been previously defined for certain indications in new indications is defined as the repurposing/repositioning of the drug. The requirement of all clinical research steps that starts from healthy volunteers, due to the slowness
Mehmet SOYLU +2 more
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Drug repositioning in Alzheimer's disease
, 2015 Drug repositioning offers an innovative approach to drug discovery with great potential in the field of Alzheimer's Disease and dementia therapeutics. Investigation of licensed compounds enables processing through the drug discovery pipeline in a rapid ...
Corbett, Anne Marie Jane +2 more
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Large-scale computational drug repositioning to find treatments for rare diseases [PDF]
, 2018 Rare, or orphan, diseases are conditions afflicting a small subset of people in a population. Although these disorders collectively pose significant health care problems, drug companies require government incentives to develop drugs for rare diseases due
Misagh Naderi +9 more
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