Results 91 to 100 of about 1,936,479 (187)

Leveraging population-based clinical quantitative phenotyping for drug repositioning

, 2017
Computational drug repositioning methods can scalably nominate approved drugs for new diseases, with reduced risk of unforeseen side effects. The majority of methods eschew individual-level phenotypes despite the promise of biomarker-driven repositioning.
Chirag J Patel, Danielle Rasooly, Adam S Brown   +2 more
core   +1 more source

Leveraging Population‐Based Clinical Quantitative Phenotyping for Drug Repositioning

, 2018
Computational drug repositioning methods can scalably nominate approved drugs for new diseases, with reduced risk of unforeseen side effects. The majority of methods eschew individual‐level phenotypes despite the promise of biomarker‐driven repositioning.
Brown, Adam S., Rasooly, Danielle, Patel, Chirag   +2 more
core   +1 more source

Drug repositioning and repurposing: terminology and definitions in literature [PDF]

, 2015
Drug repositioning and similar terms have been a trending topic in literature and represent novel drug development strategies. We analysed in a quantitative and qualitative manner how these terms were used and defined in the literature.
Mantel-Teeuwisse, Aukje K, Slijkerman, Diederick S, Schutjens, Marie-Hélène D B, Langedijk, Joris, Sub Clinical Pharmacy, Pharmacoepi, Sub Pharmacotherapy, Theoretical, Pharmacoepidemiology and Clinical Pharmacology   +6 more
core  

Recommendation techniques for drug–target interaction prediction and drug repositioning

, 2016
The usage of computational methods in drug discovery is a common practice. More recently, by exploiting the wealth of biological knowledge-bases, a novel approach called Drug-Repositioning has raised.
Alaimo, S, Salvatore Alaimo, Alfredo Pulvirenti, Rosalba Giugno, GIUGNO, ROSALBA, Pulvirenti, A., Giugno R, Alaimo S, PULVIRENTI, ALFREDO   +8 more
core   +1 more source

Identifying Drug Repositioning Candidates using Representation Learning on Heterogeneous Networks

, 2019
We used network representation learning to improve on previous network-based drug repositioning, then continued to use the methods to deconvolute the genesis of side ...
Mehdi Ali (6558515), Rana Aldisi (6851553), Lingling Xu (6851556), Charles Tapley Hoyt (4784217), Daniel Domingo-Fernández (4989203)   +4 more
core   +1 more source

Computational drug repositioning with attention walking

Scientific Reports
Drug repositioning aims to identify new therapeutic indications for approved medications. Recently, the importance of computational drug repositioning has been highlighted because it can reduce the costs, development time, and risks compared to ...
Jong-Hoon Park, Young-Rae Cho
doaj   +1 more source

COMPUTATIONAL DRUG REPOSITIONING [PDF]

Biocomputing 2013, 2012
ZHIYONG LU, PANKAJ AGARWAL, ATUL J. BUTTE   +2 more
openaire   +1 more source

Efficacy of SRM-IV Vestibular Function Diagnosis and Treatment System in Treating Benign Paroxysmal Positional Vertigo

Iranian Journal of Public Health, 2018
Background: We determined the diagnostic and therapeutic effects of SRM-IV vestibular function diagnosis and treatment system on benign paroxysmal positional vertigo (BPPV).
Nuan WANG, Hao ZHOU, Hongli HUANG, Deqin GENG, Xiuhua YANG, Chunyu YU, Di SHI   +6 more
doaj  

Leveraging bioinformatics approaches for drug repositioning in space radiation protection. [PDF]

PLoS One
Diaz TE, Kerrigan JA, Bowles DE, Kidane YH.   +3 more
europepmc   +1 more source

Drug Repositioning Based on Single-Cell Transcriptomics Data Identifies Quinidine as a Potential Drug for Treating Osteoporosis. [PDF]

Genes (Basel)
Wang R, Li JL, Liu K, Lu X, Zhang QQ, Zeng Q, Deng Y, Qu XC, Chen XD, Tan LJ.   +9 more
europepmc   +1 more source