Results 101 to 110 of about 60,427 (345)

Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices

Advanced Science, EarlyView.
This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee, Oliver James, Gaeun Jung, Doyun Lee, Yee‐Joon Kim   +4 more
wiley   +1 more source

Drug repositioning for enzyme modulator based on human metabolite-likeness

BMC Bioinformatics, 2017
Background Recently, the metabolite-likeness of the drug space has emerged and has opened a new possibility for exploring human metabolite-like candidates in drug discovery.
Yoon Hyeok Lee, Hojae Choi, Seongyong Park, Boah Lee, Gwan-Su Yi   +4 more
doaj   +1 more source

Evaluation of cervical proprioceptive function: optimizing protocols and comparison between tests in normal subjects [PDF]

, 2007
STUDY DESIGN: A test-retest design evaluated stability as well as within and between day reliability. \ud \ud OBJECTIVE: The study aimed to define optimum protocols for the cervical joint position error (JPE) and cervicocephalic kinesthesia tests and to
Miall, R. Chris
core  

Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS [PDF]

, 2012
Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify ...
Baker, D, Baneke, P, Brown, D, Browne, P, Chandraratna, D, Ciccarelli, O, Coetzee, T, Comi, G, Feinstein, A, Fox, RJ, Kapoor, R, Lee, K, Salvetti, M, Sharrock, K, Thompson, A, Toosy, A, Zaratin, P, Zuidwijk, K   +17 more
core   +2 more sources

Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells

Advanced Science, EarlyView.
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale, Luca Messina, Valeria Panzetta, Stefania Saporito, Costantino Menna, Maurizio Ventre, Paolo A. Netti   +6 more
wiley   +1 more source

Structure-based drug repositioning explains ibrutinib as VEGFR2 inhibitor.

PLoS ONE, 2020
Many drugs are promiscuous and bind to multiple targets. On the one hand, these targets may be linked to unwanted side effects, but on the other, they may achieve a combined desired effect (polypharmacology) or represent multiple diseases (drug ...
Melissa F Adasme, Daniele Parisi, Kristien Van Belle, Sebastian Salentin, V Joachim Haupt, Gary S Jennings, Jörg-Christian Heinrich, Jean Herman, Ben Sprangers, Thierry Louat, Yves Moreau, Michael Schroeder   +11 more
doaj   +1 more source

Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities

, 2018
New technologies have enabled the investigation of biology and human health at an unprecedented scale and in multiple dimensions. These dimensions include a myriad of properties describing genome, epigenome, transcriptome, microbiome, phenotype, and ...
Goldenberg, Anna, Hoffman, Michael M., Leskovec, Jure, Nguyen, Francis, Wang, Bo, Zitnik, Marinka   +5 more
core   +1 more source

Structure based de novo design of IspD inhibitors as anti-tubercular agents [PDF]

, 2012
Tuberculosis is one of the leading contagious diseases, caused by Mycobacterium tuberculosis. Despite improvements in anti-tubercular agents, it remains one of the most prevalent infectious diseases worldwide, responsible for a total of 1.6 million ...
Abhay T. Sangamwar, Gaurao V. Dhoke, Rahul P. Gangwal, Rohith Anand Varikoti, Venkata Krishnan Ramaswamy   +4 more
core   +2 more sources

A standard database for drug repositioning [PDF]

Scientific Data, 2017
AbstractDrug repositioning, the process of discovering, validating, and marketing previously approved drugs for new indications, is of growing interest to academia and industry due to reduced time and costs associated with repositioned drugs. Computational methods for repositioning are appealing because they putatively nominate the most promising ...
Brown, Adam S., Patel, Chirag J.
openaire   +3 more sources

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source