Results 101 to 110 of about 1,821,409 (281)

An integrated dataset for in silico drug discovery

Journal of Integrative Bioinformatics, 2010
Drug development is expensive and prone to failure. It is potentially much less risky and expensive to reuse a drug developed for one condition for treating a second disease, than it is to develop an entirely new compound.
Cockell Simon J, Weile Jochen, Lord Phillip, Wipat Claire, Andriychenko Dmytro, Pocock Matthew, Wilkinson Darren, Young Malcolm, Wipat Anil   +8 more
doaj   +1 more source

Summary of drug-repositioning signals.

, 2018
Summary of drug-repositioning signals.
Mitsutaka Takada (5832344), Mai Fujimoto (5832338), Lili Mao (289583), Kouichi Hosomi (5832335), Kazutaka Ushio (5832341), Juran Kato (2093692)   +5 more
core   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source

From Fluoride Removal to Interfacial Reactivity Enhancement: Functionalized La3+‐Crosslinked B/CuO Energetic Microspheres

Advanced Science, EarlyView.
A fluoride adsorption‐functionalization strategy directly couples fluoride wastewater remediation with combustion performance enhancement of B/CuO energetic microspheres. Fluoride captured from wastewater is retained within the microspheres without adsorbent regeneration or disposal, simultaneously achieving pollutant removal and enhanced energetic ...
Hongbiao Huo, Minghao Bao, Zhongbo Han, Wei Shi, Jianyong Xu, Pengfei Cui, Wenchao Zhang   +6 more
wiley   +1 more source

Drug repositioning with adaptive graph convolutional networks

, 2023
Drug repositioning is an effective strategy to identify new indications for existing drugs, providing the quickest possible transition from bench to bedside.
Li, Min, Jia, Xiao, Tang, Jing, Sun, Xinliang, Lu, Zhangli   +4 more
core   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Counterion Dynamics in Chiral Supramolecular Polymerization

Angewandte Chemie, EarlyView.
A single counterion acts as a dynamic structural element directing pathway‐dependent supramolecular polymerization. Subtle counterion repositioning governs molecular packing, aggregate morphology, supramolecular chirality, and asymmetry amplification. ABSTRACT Counterions have been studied in a broad range of chemical and biological systems, and their ...
Camila Montañez‐Moyano, Timo Krüger, Alejandro Martínez‐Manjarrés, Gustavo Fernández   +3 more
wiley   +2 more sources

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Prediction of drug–disease associations based on reinforcement symmetric metric learning and graph convolution network

Frontiers in Pharmacology
Accurately identifying novel indications for drugs is crucial in drug research and discovery. Traditional drug discovery is costly and time-consuming.
Huimin Luo, Huimin Luo, Chunli Zhu, Chunli Zhu, Jianlin Wang, Jianlin Wang, Ge Zhang, Ge Zhang, Junwei Luo, Chaokun Yan, Chaokun Yan, Chaokun Yan   +11 more
doaj   +1 more source