Results 111 to 120 of about 3,959 (186)

In vitro trypanocidal activity of the anti-helminthic drug nichlosamide

, 2008
Only a few drugs are available for chemotherapy of African trypanosomiasis and there is an urgent need for the development of new anti-trypanosomal agents.
Merschjohann, Karin, Steverding, Dietmar
core   +1 more source

Identification of Potential Trypanosoma cruzi Trans-Sialidase Inhibitors by Computational Drug Repositioning Approaches

Scientia Pharmaceutica
Chagas disease, caused by the parasitic protozoan Trypanosoma cruzi (T. cruzi), represents a worldwide public health issue. To date, there is no efficient treatment to combat this pathology, and the only drugs available are usually toxic to the patient ...
Miguel A. Uc-Chuc, Nohemi Cigarroa-Toledo, Karla Y. Acosta-Viana, José I. Chan-Pérez, Juan C. Pineda-Cortes, Hernán de J. Villanueva-Alonzo   +5 more
doaj   +1 more source

Trypanocidal properties of <i>Terminalia ivorensis</i> A. Chev. (Combretaceae)

, 2006
Human African Trypanosomiasis (sleeping sickness) cause considerable mortality and morbidity throughout the world with Trypansoma brucei, T. gambiense and T. brucei rhodesiense as the major causative agents.
Joseph M Agbedahunsi, Croft, Simon L, Adewunmi, Clement O, Clement O Adewunmi, Anao, Ivie, Simon L Croft, Ivie Anao, Agbedahunsi, Joseph M, Adewunmi, Clement O., Croft, Simon L., Agedahunsi, Joseph M.   +10 more
core   +1 more source

Synthesis, in vitro cytotoxicity and trypanocidal evaluation of novel 1, 3, 6-substituted non-fluoroquinolones

, 2018
Sleeping sickness (trypanosomiasis) is a neglected tropical disease that affects mostly the poorest communities in sub-Saharan Africa. Toxic side effects associated with the use of current anti-trypanosomal drugs, which in some cases kill faster than the
Mtshare, Thanduxolo Elihle, Hulushe, Siyabonga T., Khanye, Setshaba D, Darrell, Oliver T, Laming, Dustin, Khanye, Setshaba D., Mtshare, Thanduxolo E., Hulushe, Siyabonga T, Darrell, Oliver T., Krause, Rui W.M., Beteck, Richard M, Hoppe, Heinrich C., Krause, Rui W M, Hoppe, Heinrich C, Isaacs, Michelle, Beteck, Richard M.   +15 more
core   +1 more source

Trypanocidal activity of a thioacyl-thiosemicarbazide derivative associating both immunostimulating thalidomide and anti-parasitic thiosemicarbazide pharmacophores

, 2015
African trypanosomiasis remains a life-threatening disease and there is nowadays an urgent need for improved therapeutic agents for this pathology.
Kassehin, Comlan Urbain, Gbaguidi, Fernand A., McCurdy, Christopher R., Poupaert, Jacques   +3 more
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In vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi

, 2011
OBJECTIVES: As part of a search for new therapeutic opportunities to treat chagasic patients, in vitro efficacy studies were performed to characterize the activity of five novel arylimidamides (AIAs) against Trypanosoma cruzi.
Junqueira, Angela, Stephens, Chad E., Soeiro, Maria de Nazaré Correia, Lima, Marli Maria, Som, Phanneth, Boykin, David W., Silva, Cristiane França Da, Romanha, Alvaro José, Sales Junior, Policarpo Ademar   +8 more
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Design, Synthesis, and Trypanocidal Activity of Novel 5-Nitroimidazolyl O -Benzyloxime Ethers

, 2017
In this paper, we describe the synthesis and the action against of the trypomastigote form of Trypanosoma cruzi of a new class of nitroimidazole-2-carbaldehyde O-benzyloximes.
Edson Ferreira da Silva, Osorio, Luis Felipe Baumotte, Wardell, Solange M. S. V., Samir Aquino Carvalho, Carvalho, Samir Aquino, Solange Lisboa de Castro, Castro, Solange Lisboa de, James Lewis Wardell, Solange M. S. V. Wardell, Carlos Alberto Manssour Fraga, Luis Felipe Baumotte Osorio, Wardell, James Lewis, Kelly Salomão, Silva, Edson Ferreira da, Fraga, Carlos Alberto Manssour, Salomão, Kelly   +15 more
core   +1 more source

Natural and semisynthetic analogues of manadoperoxide b reveal new structural requirements for trypanocidal activity

, 2018
Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3).
Tasdemir, Deniz, Calcinai, Barbara, Taglialatela-Scafati, Orazio, Chianese, Giuseppina, Kaiser, Marcel, Dien, Henny, Cerrano, Carlo, Scala, Fernando   +7 more
core  

Gossypol: a potential trypanocidal agent [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 1985
openaire   +3 more sources

Structural planning, synthesis and evaluation of properties trypanocidal aryl-1,3-thiazoles

, 2016
FACEPE, CAPES, CNPq.Chagas disease is a parasitic infection caused by protozoan T. cruzi, which affects around 7 million people worldwide. Benznidazole (BZD) is the sole drug approved for treatment during the acute and asymptomatic chronic phases ...
Oliveira, Ulisses José Félix Tenório de, Miranda Filho, Carlos André Laranjeira, Moreira, Diogo Rodrigo Magalhães, Meira, Cássio Santana, Soares, Milena Botelho Pereira, Leite, Ana Cristina Lima, Barbosa, Miria de Oliveira, Siqueira, Lucianna Râbelo Pessôa de, Oliveira Filho, Gevanio Bezerra de, Oliveira, Arsênio Rodrigues   +9 more
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