Results 91 to 100 of about 3,959 (186)

New drugs against trypanosomatid parasites : rediscovery of fexinidazole [PDF]

, 2014
Neglected tropical diseases (NTDs) are a group of communicable diseases mostly affecting people in developing countries. These diseases are responsible for a major part of the global morbidity, mortality and poverty. There is no doubt that the well-being
Kaiser, Marcel
core   +1 more source

oxazepines as Potential New Trypanocidal Agents

, 2021
African and American trypanosomiases are estimated to affect several million people across the world, with effective treatments distinctly lacking.
Roberto Fino, Valeria Napolitano, Maciej Dawidowski (8231469), Ralf Erdmann, Vishal C. Kalel (8231472), Gisbert Schneider, Gisbert Schneider (17096), Ryan Byrne, Oliver Plettenburg (481045), Dominik Lenhart, Roberto Fino (8231478), Grzegorz M. Popowicz, Ryan Byrne (11513863), Dominik Lenhart (6060077), Ralf Erdmann (170790), Michael Sattler, Oliver Plettenburg, Charlotte A. Softley, Wolfgang Schliebs, Vishal C. Kalel, Charlotte A. Softley (11513860), Maciej Dawidowski, Grzegorz M. Popowicz (179378), Michael Sattler (17373), Valeria Napolitano (8231475), Wolfgang Schliebs (170794)   +25 more
core   +1 more source

Antitrypanosomal Activity and Molecular Docking Studies of Lobetyolin From Lobelia rhynchopetalum Hemsl. Root Extract Against Trypanosoma congolense Field Isolates

BioMed Research International, Volume 2026, Issue 1, 2026.
Currently available drugs for trypanosomiasis are few, and their use is limited by toxicity and growing resistance. This highlights the need for safer and more effective alternatives. In this study, the in vitro and in vivo antitrypanosomal activities of an 80% methanol root extract of Lobelia rhynchopetalum and its major constituent were evaluated ...
Selamawit Yimer, Eyael Tewelde, Daniel Bisrat, Solomon Tadesse, Mariamawit Y. Yeshak, Rahul Shivahare   +5 more
wiley   +1 more source

Synthesis of 1,2,6-Thiadiazin 1,1-Dioxide Derivatives as Trypanocidal Agents

, 2014
: It describes the synthesis of new 1,2,6-Thiadiazin 1,1-dioxide derivatives using condensation of the Knoevenagel type.
A. Gómez-barrio, H. Cerecetto, C. Ochoa, R. Di Maio, S. Muelas, G. Seoane   +5 more
core  

Studies toward the structural optimization of new brazilizone-related trypanocidal 1,3,4-thiadiazole-2-arylhydrazone derivatives

, 2008
Produção científica do Laboratório de Biologia Celular.Megazol is a highly active compound against Trypanosoma cruzi, and has become a core structure for the design of new trypanocidal agents. Recently, we have identified the new potent trypanocide agent
Carvalho, Samir D'Aquino, Silva, Edson Ferreira da, Romeiro, Nelilma Correia, Fraga, Carlos Alberto Manssour, Lopes, Francisco de Assis Santos, Castro, Solange Lisboa de, Salomão, Kelly, Wardell, Solange Maria Silva Veloso   +7 more
core   +1 more source

Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

eLife
African trypanosomes are the causative agents of neglected tropical diseases affecting both humans and livestock. Disease control is highly challenging due to an increasing number of drug treatment failures.
Joar Esteban Pinto Torres, Mathieu Claes, Rik Hendrickx, Meng Yuan, Natalia Smiejkowska, Pieter Van Wielendaele, Aysima Hacisuleyman, Hans De Winter, Serge Muyldermans, Paul AM Michels, Malcolm D Walkinshaw, Wim Versées, Guy Caljon, Stefan Magez, Yann G-J Sterckx   +14 more
doaj   +1 more source

Comparative in vitro trypanocidal activities of petroleum ether, chloroform, methanol and aqueous extracts of some Nigerian savannah plants

, 2005
Using Trypanosoma brucei   as test organism, about two hundred extracts of varying polarities obtained from different parts of about forty tropical plants harvested from the savannah vegetational belt of Nigeria were evaluated for their in vitro ...
Atawodi, Sunday E, Sunday E. Atawodi
core   +2 more sources

Insights into Chagas treatment based on the potential of bacteriocin AS-48

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Chagas disease caused by the protozoan parasite Trypanosoma cruzi represents a significant public health problem in Latin America, affecting around 8 million cases worldwide.
Rubén Martín-Escolano, Rubén Cebrián, Javier Martín-Escolano, Maria J. Rosales, Mercedes Maqueda, Manuel Sánchez-Moreno, Clotilde Marín   +6 more
doaj   +1 more source

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs [PDF]

, 2013
Objectives: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T.
Lee, Rebecca S, Burchmore, Richard J S, Natto, Manal J, Eze, Anthonius, Graf, Fabrice, Burchmore, Richard JS, Lee, Rebecca, de Koning, Harry, Glover, Lucy, Mäser, Pascal, Teka, Ibrahim, Barrett, Michael P., Munday, Jane C., Teka, Ibrahim A., De Koning, Harry P., Eze, Anthonius A, Graf, Fabrice E., De Koning, Harry P, Ludin, Philipp, McDonald, Jennifer, MacLeod, Annette, Turner, C Michael R., Munday, Jane C, Natto, Manal J., Lee, Rebecca S., Tait, Andy, Horn, David, Baker, Nicola, Munday, Jane, Turner, C Michael R, Aguinaga Andres, David, Barrett, Michael P, Andrés, David Aguinaga, Burchmore, Richard, Clucas, Caroline, Graf, Fabrice E, Horn, David; id_orcid, Burchmore, Richard J. S., Teka, Ibrahim A, Eze, Anthonius A., Natto, Manal, Turner, C. Michael R., Barrett, Michael   +42 more
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The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence. [PDF]

, 2015
BACKGROUND: The neglected parasitic infection Chagas disease is rapidly becoming a globalised public health issue due to migration. There are only two anti-parasitic drugs available to treat this disease, benznidazole and nifurtimox. Thus it is important
Fortes Francisco, A, Martin C Taylor, John M Kelly, Michael D Lewis, Shane R. Wilkinson (721807), Fortes Francisco, Amanda, Amanda Fortes Francisco (330407), Taylor, Martin C, Lewis, MD, Amanda Fortes Francisco, Wilkinson, SR, Michael D. Lewis (172100), Taylor, MC, Lewis, Michael D, Kelly, JM, Shane R Wilkinson, Wilkinson, Shane R, Kelly, John M, Martin C. Taylor (449215), John M. Kelly (488103)   +19 more
core   +1 more source