Results 11 to 20 of about 7,518 (197)

Synthesis of New Hybrid Derivatives from Metronidazole and Eugenol Analogues as Trypanocidal Agents

Journal of Pharmacy & Pharmaceutical Sciences, 2021
Background: The search for new drug compounds is always challenging and there are several different strategies that involve the most varied and creative approaches in medicinal chemistry. One of them is the technique of molecular hybridisation: forming a
Mônica Fraccarolli Pelozo , Giovanna Fiori Serpa Lima , Cleydson Finotti Cordeiro , Luana Sueli Silva, Ivo Santana Caldas , Diogo Teixeira Carvalho , Stefânia Neiva Lavorato , Jamie Anthony Hawkes, Lucas Lopardi Franco   +8 more
doaj   +4 more sources

Synthesis of 1,2,6-Thiadiazin 1,1-Dioxide Derivatives as Trypanocidal Agents [PDF]

Molecules, 2000
It describes the synthesis of new 1,2,6-Thiadiazin 1,1-dioxide derivatives using condensation of the Knoevenagel type. The products are evaluated in vitro as trypanocidal agents.
H. Cerecetto, R. Di Maio, G. Seoane, C. Ochoa, S. Muelas, A. Gómez-Barrio   +5 more
doaj   +2 more sources

Natural Sesquiterpene Lactones as Potential Trypanocidal Therapeutic Agents: A Review [PDF]

Natural Product Communications, 2016
Chagas’ disease and Human African Trypanosomiasis are parasitic diseases that remain major health problems, mainly among the poorest and the most marginalized communities from Latin America and Africa.
Liliana V. Muschietti, Jerónimo L. Ulloa   +1 more
doaj   +3 more sources

Mechanistic Exploration of N,N′-Disubstituted Diamines as Promising Chagas Disease Treatments [PDF]

Pharmaceuticals
Introduction: Chagas disease, caused by the protozoan Trypanosoma cruzi, remains a major public health concern due to the limited effectiveness of current treatments, especially in the chronic stage.
Alejandro I. Recio-Balsells, Chantal Reigada, María Gabriela Mediavilla, Esteban Panozzo-Zénere, Miguel Villarreal Parra, Patricia S. Doyle, Juan C. Engel, Claudio A. Pereira, Julia A. Cricco, Guillermo R. Labadie   +9 more
doaj   +2 more sources

Repositioning FDA-Approved Sulfonamide-Based Drugs as Potential Carbonic Anhydrase Inhibitors in Trypanosoma cruzi: Virtual Screening and In Vitro Studies [PDF]

Pharmaceuticals
Background/Objectives: α-carbonic anhydrase (α-TcCA) has emerged as a promising drug target in T. cruzi, the causative agent of Chagas disease in the Americas. Sulfonamides, known inhibitors of CAs, bind to the zinc ion on the enzyme’s active site.
Eyra Ortiz-Pérez, Adriana Moreno-Rodríguez, Timoteo Delgado-Maldonado, Jessica L. Ortega-Balleza, Alonzo González-González, Alma D. Paz-González, Karina Vázquez, Guadalupe Avalos-Navarro, Simone Giovannuzzi, Claudiu T. Supuran, Gildardo Rivera   +10 more
doaj   +2 more sources

Huprines as a new family of dual acting trypanocidal–antiplasmodial agents [PDF]

Bioorganic & Medicinal Chemistry, 2011
A series of 19 huprines has been evaluated for their activity against cultured bloodstream forms of Trypanosoma brucei and Plasmodium falciparum. Moreover, cytotoxicity against rat myoblast L6 cells was assessed for selected huprines. All the tested huprines are moderately potent and selective trypanocidal agents, exhibiting IC(50) values against T ...
Defaux, J., Sala, M., Formosa, X., Galdeano, C., Taylor, M.C., Kelly, J.M., Wright, Colin W., Camps, P., Muñoz-Torrero, D., Alobaid, Waleed A.A.   +9 more
openaire   +6 more sources

Synthesis and Biological Evaluation of Tetrahydroisoquinoline Derivatives as Trypanocidal Agents [PDF]

ACS Omega
João Paulo de Moura Lopes, Gabriel Vitor de Lima Marques, Lucas Abreu Diniz, Viviane Côrrea Santos, Daniela de Melo Resende, Silvane Maria Fonseca Murta, Markus Kohlhoff, Vinícius Gonçalves Maltarollo, Rafaela Salgado Ferreira, Renata Barbosa Oliveira   +9 more
doaj   +2 more sources

Evaluation of substituted ebselen derivatives as potential trypanocidal agents. [PDF]

Bioorg Med Chem Lett, 2017
Human African trypanosomiasis is a disease of sub-Saharan Africa, where millions are at risk for the illness. The disease, commonly referred to as African sleeping sickness, is caused by an infection by the eukaryotic pathogen, Trypanosoma brucei. Previously, a target-based high throughput screen revealed ebselen (EbSe), and its sulfur analog, EbS, to ...
Gordhan HM, Patrick SL, Swasy MI, Hackler AL, Anayee M, Golden JE, Morris JC, Whitehead DC.   +7 more
europepmc   +4 more sources

Electrocardiographic Abnormalities and Treatment with Benznidazole among Children with Chronic Infection by Trypanosoma cruzi: A Retrospective Cohort Study [PDF]

, 2016
Background: Chronic infection by Trypanosoma cruzi could cause heart conduction disturbances. We sought to analyze electrocardiographic abnormalities among children with chronic T. cruzi infection with and without trypanocidal treatment with benznidazole.
Colantonio, Lisandro Damián, Prado, Nilda, Segura, Elsa Leonor, Sosa-Estani, Sergio Alejandro   +3 more
core   +20 more sources

Trypanocidal Effects of Polyprenylated Benzophenone Enriched Brazilian Red Propolis Extract and Its Isolated Constituent. [PDF]

Chem Biodivers
In vitro trypanocidal activity of a polyprenylated benzophenone‐enriched Brazilian red propolis extract (SEBz) and its major constituents, guttiferone E/xanthochymol (GUT/XAN) and oblongifolin B (OBL), exhibit in vitro trypanocidal activity against Trypanosoma cruzi, inducing ultrastructural damage with moderate cytotoxicity and no significant ...
Oliveira ND, Pagotti MC, Paula LAL, Paixão MZ, Albino Dos Santos D, de Freitas RF, Ambrósio SR, Veneziani RCS, Bastos JK, Magalhães LG.   +9 more
europepmc   +2 more sources