Results 11 to 20 of about 3,959 (186)

Huprines as a new family of dual acting trypanocidal–antiplasmodial agents [PDF]

Bioorganic and Medicinal Chemistry, 2011
A series of 19 huprines has been evaluated for their activity against cultured bloodstream forms of Trypanosoma brucei and Plasmodium falciparum. Moreover, cytotoxicity against rat myoblast L6 cells was assessed for selected huprines.
Carles Galdeano, Martin C Taylor, John M Kelly   +2 more
exaly   +7 more sources

TcSR62, an RNA-binding protein, as a new potential target for anti-trypanocidal agents [PDF]

Frontiers in Microbiology
Trypanosomatids are parasites of health importance that cause neglected diseases in humans and animals. Chagas’ disease, caused by Trypanosoma cruzi, affects 6–7 millions of people worldwide, mostly in Latin America, most of whom do not have access to ...
Analía G. Níttolo, Analía G. Níttolo, Agustina M. Chidichimo, Agustina M. Chidichimo, Ana L. Benacerraf, Timothy Cardozo, M. Clara Corso, M. Clara Corso, Valeria Tekiel, Valeria Tekiel, Javier G. De Gaudenzi, Javier G. De Gaudenzi, Gabriela Vanesa Levy, Gabriela Vanesa Levy   +13 more
doaj   +4 more sources

Natural Sesquiterpene Lactones as Potential Trypanocidal Therapeutic Agents: A Review [PDF]

Natural Product Communications, 2016
Chagas’ disease and Human African Trypanosomiasis are parasitic diseases that remain major health problems, mainly among the poorest and the most marginalized communities from Latin America and Africa.
Liliana V. Muschietti, Jerónimo L. Ulloa   +1 more
doaj   +4 more sources

In Silico Studies and Biological Evaluation of Thiosemicarbazones as Cruzain-Targeting Trypanocidal Agents for Chagas Disease [PDF]

Pharmaceutics
Background/Objectives: Chagas disease remains a major unmet medical need due to the limited efficacy and safety of current therapies. Here, we investigated sixteen thiosemicarbazone (TSC) derivatives as cruzain inhibitors using an integrated in silico/in
Lidiane Meier, Milena F. C. V. de Melo, Heitor R. Abreu, Isabella M. e Oliveira, Larissa Sens, Thiago H. Doring, Renata Krogh, Adilson Beatriz, Adriano D. Andricopulo, Sumbal Saba, Aldo S. de Oliveira, Jamal Rafique   +11 more
doaj   +5 more sources

Synthesis and Biological Evaluation of Tetrahydroisoquinoline Derivatives as Trypanocidal Agents [PDF]

ACS Omega
American trypanosomiasis is a parasitic illness of major public health relevance, resulting from infection with the protozoan Trypanosoma cruzi and predominantly impacting populations in low-resource settings. Current treatments, benznidazole and nifurtimox, are limited by their efficacy in the chronic phase, toxicity, and side effects, necessitating ...
João Paulo de Moura Lopes, Gabriel Vitor de Lima Marques, Lucas Abreu Diniz, Viviane Côrrea Santos, Daniela de Melo Resende, Silvane Maria Fonseca Murta, Markus Kohlhoff, Vinícius Gonçalves Maltarollo, Rafaela Salgado Ferreira, Renata Barbosa Oliveira   +9 more
doaj   +5 more sources

Terpenoid Derivatives as Potential Trypanocidal Agents [PDF]

Medicinal chemistry, 2016
In this review we refer to a promising family of molecules in the fight against Chagas disease. Terpene derivatives are abundant in the plant Kingdom and in the last years many compounds have shown important biological activities.
Spina Zapata, Renata María, Sosa Escudero, Miguel Angel, Lozano, Esteban Sebastián, Barrera, Patricia Andrea   +3 more
core   +5 more sources

Identification of Novel Trypanosoma cruzi Cysteine Protease Inhibitors via Ligand-Based Virtual Screening of FDA-Approved Drugs with Trypanocidal Activity [PDF]

Diseases
Background: Chagas disease is a major public health problem, especially in Latin American countries, and benznidazole and nifurtimox are currently the only drugs available for its treatment.
Lenci K. Vázquez-Jiménez, Alonzo González-González, Timoteo Delgado-Maldonado, Rogelio Gómez-Escobedo, Benjamín Nogueda-Torres, Ana Verónica Martínez-Vázquez, Eyrá Ortiz-Pérez, Charmina Aguirre-Alvarado, Verónica Alcántara-Farfán, Joaquín Cordero-Martínez, Lorena Rodríguez-Páez, Adriana Moreno-Rodriguez, Gildardo Rivera   +12 more
doaj   +2 more sources

Synthesis of New Hybrid Derivatives from Metronidazole and Eugenol Analogues as Trypanocidal Agents

Journal of Pharmacy & Pharmaceutical Sciences, 2021
Background: The search for new drug compounds is always challenging and there are several different strategies that involve the most varied and creative approaches in medicinal chemistry. One of them is the technique of molecular hybridisation: forming a
Mônica Fraccarolli Pelozo , Giovanna Fiori Serpa Lima , Cleydson Finotti Cordeiro , Luana Sueli Silva, Ivo Santana Caldas , Diogo Teixeira Carvalho , Stefânia Neiva Lavorato , Jamie Anthony Hawkes, Lucas Lopardi Franco   +8 more
doaj   +4 more sources

Molecular design aided by random forests and synthesis of potent trypanocidal agents as cruzain inhibitors for Chagas disease treatment

Chemical Biology and Drug Design, 2020
Cruzain is an established target for the identification of novel trypanocidal agents, but how good are in vitro/in vivo correlations? This work describes the development of a random forests model for the prediction of the bioavailability of cruzain ...
Sérgio Albuquerque, Lorenzo Cianni, Paula Gomes   +2 more
exaly   +2 more sources

Mechanistic Exploration of N,N′-Disubstituted Diamines as Promising Chagas Disease Treatments [PDF]

Pharmaceuticals
Introduction: Chagas disease, caused by the protozoan Trypanosoma cruzi, remains a major public health concern due to the limited effectiveness of current treatments, especially in the chronic stage.
Alejandro I. Recio-Balsells, Chantal Reigada, María Gabriela Mediavilla, Esteban Panozzo-Zénere, Miguel Villarreal Parra, Patricia S. Doyle, Juan C. Engel, Claudio A. Pereira, Julia A. Cricco, Guillermo R. Labadie   +9 more
doaj   +2 more sources