Results 1 to 10 of about 9,952 (165)

Development of Novel Isoindolone‐Based Compounds against Trypanosoma brucei rhodesiense [PDF]

ChemistryOpen, 2021
This study identified the isoindolone ring as a scaffold for novel agents against Trypanosoma brucei rhodesiense and explored the structure‐activity relationships of various aromatic ring substitutions.
Daniel G Silva, An Matheeussen, Lucie Grey   +2 more
exaly   +8 more sources

C-Terminal Mutants of Apolipoprotein L-I Efficiently Kill Both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense [PDF]

PLoS Pathogens, 2009
Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T.
Laurence Lecordier, Benoit Vanhollebeke, Patricia Tebabi   +2 more
exaly   +6 more sources

De Novo Genome Assembly Shows Genome Wide Similarity between Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense [PDF]

PLoS ONE, 2016
BACKGROUND:Trypanosoma brucei is a eukaryotic pathogen which causes African trypanosomiasis. It is notable for its variant surface glycoprotein (VSG) coat, which undergoes antigenic variation enabled by a large suite of VSG pseudogenes, allowing for ...
Mark Sistrom, Benjamin R Evans, Joshua B Benoit   +2 more
exaly   +6 more sources

Decolonising Parasitology: The Case of Trypanosoma brucei rhodesiense [PDF]

Trends in Parasitology, 2021
Trypanosoma brucei rhodesiense was named after Rhodesia which, in turn, was named after the British imperialist and white supremacist Cecil Rhodes. In the light of the Black Lives Matter movement and contemporary consciousness of postcolonial legacy, it seems opportune to reconsider the subspecies name. Pros and cons of renaming T. b.
Dietmar Steverding, Kevin M Tyler
exaly   +4 more sources

Target product profile: diagnostic test for <i>Trypanosoma brucei rhodesiense</i>. [PDF]

Bull World Health Organ, 2023
Rhodesiense human African trypanosomiasis is a lethal parasitic infection caused by Trypanosoma brucei rhodesiense and transmitted by tsetse flies in eastern and southern Africa. It accounts for around 5% of all cases of human African trypanosomiasis.
Priotto G, Franco JR, Lejon V, Büscher P, Matovu E, Ndung'u J, Biéler S, Mumba D, Van Reet N, Verlé P, Jamonneau V, Simarro PP, Ebeja AK, Sankara D, Dagne DA.   +14 more
europepmc   +3 more sources

Transcriptome profiles of Trypanosoma brucei rhodesiense in Malawi reveal focus specific gene expression profiles associated with pathology. [PDF]

PLoS Neglected Tropical Diseases
BackgroundSleeping sickness caused by Trypanosoma brucei rhodesiense is a fatal disease and endemic in Southern and Eastern Africa. There is an urgent need to develop novel diagnostic and control tools to achieve elimination of rhodesiense sleeping ...
Peter Nambala, Harry Noyes, Joyce Namulondo, Oscar Nyangiri, Vincent Pius Alibu, Barbara Nerima, Annette MacLeod, Enock Matovu, Janelisa Musaya, Julius Mulindwa, TrypanoGEN+ Research Group as Members of the H3Africa Consortium   +10 more
doaj   +2 more sources

Reemergence of Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense, Ethiopia [PDF]

Emerging Infectious Diseases
We report 4 cases of human African trypanosomiasis that occurred in Ethiopia in 2022, thirty years after the last previously reported case in the country. Two of 4 patients died before medicine became available.
Adugna Abera, Tihitina Mamecha, Ebise Abose, Belachew Bokicho, Agune Ashole, Tesfahun Bishaw, Abinet Mariyo, Buzayehu Bogale, Haileyesus Terefe, Henok Tadesse, Mahlet Belachew, Hailemariam Difabachew, Araya Eukubay, Solomon Kinde, Abraham Ali, Feyesa Regasa, Fikre Seife, Zeyede Kebede, Mesfin Wossen, Getachew Tollera, Mesay Hailu, Nigus Manaye, Nick Van Reet, Gerardo Priotto, Johan van Griensven, Myrthe Pareyn, Geremew Tasew   +26 more
doaj   +2 more sources

Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. [PDF]

Cell Mol Life Sci, 2016
Trypanosoma brucei rhodesiense is one of the causative agents of human sleeping sickness, a fatal disease that is transmitted by tsetse flies and restricted to Sub-Saharan Africa. Here we investigate two independent lines of T. b. rhodesiense that have been selected with the drugs melarsoprol and pentamidine over the course of 2 years, until they ...
Graf FE, Ludin P, Arquint C, Schmidt RS, Schaub N, Kunz Renggli C, Munday JC, Krezdorn J, Baker N, Horn D, Balmer O, Caccone A, de Koning HP, Mäser P.   +13 more
europepmc   +8 more sources

Development of a camelid single-domain antibody-based antigen detection assay for the pan-specific diagnosis of active human and animal Trypanosoma brucei infections [PDF]

Journal of Clinical Microbiology
Trypanosoma brucei infections cause African trypanosomiasis, also known as sleeping sickness in humans and nagana in animals, presenting a significant global health and economic burden, especially in sub-Saharan Africa.
Zeng Li, Bo-kyung Jin, Emily Estefania Timaury Moreno, Andrés Álvarez-Rodríguez, Jo A. Van Ginderachter, Magdalena Radwanska, Yann G. -J. Sterckx, Benoit Stijlemans, Stefan Magez   +8 more
doaj   +2 more sources

African Trypanosomiasis Research at a Crossroads: Bibliometric and Systematic Insights for the Future. [PDF]

J Parasitol Res
Aim Despite a reduction in the overall incidence and prevalence in the last two decades, trypanosomiasis continues to be a public health concern in Africa. This study was designed to comprehensively evaluate current trends in trypanosomiasis research using bibliometric approaches to uncover emerging topics and knowledge gaps, thereby guiding future ...
Ogra IO, Adaji JZ, Jonathan EU, Nwajiani BK, Usman S, Kurovsky A, Sossou K, Balogun EO.   +7 more
europepmc   +2 more sources