Results 1 to 10 of about 14,283 (207)

Development of Novel Isoindolone‐Based Compounds against Trypanosoma brucei rhodesiense [PDF]

ChemistryOpen, 2021
This study identified the isoindolone ring as a scaffold for novel agents against Trypanosoma brucei rhodesiense and explored the structure‐activity relationships of various aromatic ring substitutions.
Dr. Daniel G. Silva, Pim‐Bart Feijens, Rik Hendrickx, An Matheeussen, Lucie Grey, Prof. Dr. Guy Caljon, Prof. Dr. Louis Maes, Prof. Dr. Flavio S. Emery, Dr. Anna Junker   +8 more
doaj   +7 more sources

Population genetics of Trypanosoma brucei rhodesiense: clonality and diversity within and between foci. [PDF]

PLoS Neglected Tropical Diseases, 2013
African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development.
Craig W Duffy, Lorna MacLean, Lindsay Sweeney, Anneli Cooper, C Michael R Turner, Andy Tait, Jeremy Sternberg, Liam J Morrison, Annette MacLeod   +8 more
doaj   +40 more sources

Reemergence of Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense, Ethiopia [PDF]

Emerging Infectious Diseases
We report 4 cases of human African trypanosomiasis that occurred in Ethiopia in 2022, thirty years after the last previously reported case in the country. Two of 4 patients died before medicine became available.
Adugna Abera, Tihitina Mamecha, Ebise Abose, Belachew Bokicho, Agune Ashole, Tesfahun Bishaw, Abinet Mariyo, Buzayehu Bogale, Haileyesus Terefe, Henok Tadesse, Mahlet Belachew, Hailemariam Difabachew, Araya Eukubay, Solomon Kinde, Abraham Ali, Feyesa Regasa, Fikre Seife, Zeyede Kebede, Mesfin Wossen, Getachew Tollera, Mesay Hailu, Nigus Manaye, Nick Van Reet, Gerardo Priotto, Johan van Griensven, Myrthe Pareyn, Geremew Tasew   +26 more
doaj   +4 more sources

Whole-Genome Sequencing of Trypanosoma brucei Reveals Introgression between Subspecies That Is Associated with Virulence [PDF]

mBio, 2013
Human African trypanosomiasis is caused by two subspecies of Trypanosoma brucei. Trypanosoma brucei rhodesiense is found in East Africa and frequently causes acute disease, while Trypanosoma brucei gambiense is found in West Africa and is associated with
Ian Goodhead, Paul Capewell, J. Wendi Bailey, Tanja Beament, Michael Chance, Suzanne Kay, Sarah Forrester, Annette MacLeod, Mark Taylor, Harry Noyes, Neil Hall   +10 more
doaj   +7 more sources

Development of a camelid single-domain antibody-based antigen detection assay for the pan-specific diagnosis of active human and animal Trypanosoma brucei infections [PDF]

Journal of Clinical Microbiology
Trypanosoma brucei infections cause African trypanosomiasis, also known as sleeping sickness in humans and nagana in animals, presenting a significant global health and economic burden, especially in sub-Saharan Africa.
Zeng Li, Bo-kyung Jin, Emily Estefania Timaury Moreno, Andrés Álvarez-Rodríguez, Jo A. Van Ginderachter, Magdalena Radwanska, Yann G. -J. Sterckx, Benoit Stijlemans, Stefan Magez   +8 more
doaj   +2 more sources

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof-of-Concept Study. [PDF]

ChemMedChem
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Lowe S, Satikuvar V, Syeda TM, Cal M, Mäser P, Kaiser M, Kadri H.   +6 more
europepmc   +2 more sources

Haemoparasitic Infections in Cattle from a Trypanosoma brucei Rhodesiense Sleeping Sickness Endemic District of Eastern Uganda [PDF]

Tropical Medicine and Infectious Disease, 2020
We carried out a baseline survey of cattle in Kaberamaido district, in the context of controlling the domestic animal reservoir of Trypanosoma brucei rhodesiense human African trypanosomiasis (rHAT) towards elimination.
Enock Matovu, Claire Mack Mugasa, Peter Waiswa, Annah Kitibwa, Alex Boobo, Joseph Mathu Ndung’u   +5 more
doaj   +2 more sources

Cytotoxicity and Antimicrobial Activity of GaMF1 Analogs. [PDF]

ChemMedChem
GaMF1 is a reported, highly potent inhibitor of mycobacterial ATP synthase. Structural modification of this scaffold significantly changes biological activity. We present GaMF1 analogues with strong antiparasitic effects, potential antiproliferative properties, and discuss the selectivity limitations of the parent compound and its analogues.
Chasák J, Vyvlečka P, Nemec I, Matheeussen A, Van Pelt N, Cos P, Caljon G, Kryštof V, Brulíková L.   +8 more
europepmc   +2 more sources

Transcriptomes of Trypanosoma brucei rhodesiense from sleeping sickness patients, rodents and culture: Effects of strain, growth conditions and RNA preparation methods. [PDF]

PLoS Negl Trop Dis, 2018
All of our current knowledge of African trypanosome metabolism is based on results from trypanosomes grown in culture or in rodents. Drugs against sleeping sickness must however treat trypanosomes in humans.
Mulindwa J, Leiss K, Ibberson D, Kamanyi Marucha K, Helbig C, Melo do Nascimento L, Silvester E, Matthews K, Matovu E, Enyaru J, Clayton C.   +10 more
europepmc   +5 more sources

Therapeutic Strategies against Leishmania and Trypanosoma

Pathogens, 2023
Human African trypanosomiasis (also known as sleeping sickness, with Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense as etiological agents), American trypanosomiasis (also known as Chagas disease, with Trypanosoma cruzi as the etiological
André L. S. Santos, Igor A. Rodrigues, Claudia M. d’Avila-Levy, Cátia L. Sodré, Koert Ritmeijer, Marta H. Branquinha   +5 more
doaj   +1 more source