Results 31 to 40 of about 59,489 (194)

Wild chimpanzees are infected by Trypanosoma brucei

International Journal for Parasitology: Parasites and Wildlife, 2015
Although wild chimpanzees and other African great apes live in regions endemic for African sleeping sickness, very little is known about their trypanosome infections, mainly due to major difficulties in obtaining their blood samples.
Milan Jirků, Jan Votýpka, Klára J. Petrželková, Kateřina Jirků-Pomajbíková, Eva Kriegová, Roman Vodička, Felix Lankester, Siv Aina J. Leendertz, Roman M. Wittig, Christophe Boesch, David Modrý, Francisco J. Ayala, Fabian H. Leendertz, Julius Lukeš   +13 more
doaj   +1 more source

Suramin action in African trypanosomes involves a RuvB-like DNA helicase

International Journal for Parasitology: Drugs and Drug Resistance, 2023
Suramin is one of the oldest drugs in use today. It is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense, and it is also used for surra in camels caused by Trypanosoma evansi ...
Anna Albisetti, Silvan Hälg, Martin Zoltner, Pascal Mäser, Natalie Wiedemar   +4 more
doaj   +1 more source

Focus–specific clinical profiles in human African trypanosomiasis caused by Trypanosoma brucei rhodesiense [PDF]

, 2010
<p><b>Background:</b> Diverse clinical features have been reported in human African trypanosomiasis (HAT) foci caused by <i>Trypanosoma brucei rhodesiense</i> (<i>T.b.rhodesiense</i>) giving rise to the ...
Odiit, Martin, Martin Odiit, Sternberg, J.M., Sternberg, Jeremy M, Peter G E Kennedy, MacLean, Lorna M, Chisi, J.E., Chisi, John, Peter G. E. Kennedy, Lorna M MacLean, Jeremy M Sternberg, John E. Chisi, Odiit, M., Kennedy, Peter, Kennedy, P.G.E., Jeremy M. Sternberg, Lorna M. MacLean, John E Chisi, MacLean, L.M.   +18 more
core   +2 more sources

Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase [PDF]

Antimicrobial Agents and Chemotherapy, 1990
A structural analog, 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxy adenosine (MDL 73811), of decarboxy S-adenosyl-L-methionine, the product of the reaction catalyzed by S-adenosyl-L-methionine (AdoMet) decarboxylase (DC), was found to inhibit Trypanosoma brucei brucei AdoMet DC.
A J, Bitonti, T L, Byers, T L, Bush, P J, Casara, C J, Bacchi, A B, Clarkson, P P, McCann, A, Sjoerdsma   +7 more
openaire   +2 more sources

The burden of human African trypanosomiasis.

PLoS Neglected Tropical Diseases, 2008
Human African trypanosomiasis (HAT, or sleeping sickness) is a protozoan parasitic infection caused by Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense. These are neglected tropical diseases, and T.b. rhodesiense HAT is a zoonosis.
Eric M Fèvre, Beatrix V Wissmann, Susan C Welburn, Pascal Lutumba   +3 more
doaj   +1 more source

A pilot study demonstrating the identification of Trypanosoma brucei gambiense and T. b. rhodesiense in vectors using a multiplexed high-resolution melt qPCR.

PLoS Neglected Tropical Diseases, 2020
Human African Trypanosomiasis (HAT) is a potentially fatal parasitic infection caused by the trypanosome sub-species Trypanosoma brucei gambiense and T. b. rhodesiense transmitted by tsetse flies. Currently, global HAT case numbers are reaching less than
Gala Garrod, Emily R Adams, Jessica K Lingley, Isabel Saldanha, Stephen J Torr, Lucas J Cunningham   +5 more
doaj   +1 more source

Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by Trypanolytic factor 1 [PDF]

, 2011
<p><b>Background:</b> The three sub-species of <i>Trypanosoma brucei</i> are important pathogens of sub-Saharan Africa. <i>T. b.
C. Michael R. Turner, Hajduk, Stephen L., Capewell, P., Hajduk Stephen L., Stephen L Hajduk, C Michael R Turner, Annette MacLeod, Stephen L. Hajduk, Turner, C.M.R., Berriman, Matthew, MacLeod Annette, Paul Capewell, Nicola J Veitch, MacLeod, A., MacLeod, Annette, Hajduk, S.L., Veitch, Nicola J., Nicola J. Veitch, Berriman, M., Jayne Raper, Raper, J., Turner C. Michael R., Raper, Jayne, Veitch, N.J., Matthew Berriman, Capewell, Paul, Raper Jayne, Capewell Paul, R. Turner, C. Michael, Veitch Nicola J., Berriman Matthew   +30 more
core   +1 more source

Comparative analysis of cerebrospinal fluid from the meningo-encephalitic stage of T. b. gambiense and rhodesiense sleeping sickness patients using TMT quantitative proteomics

Data in Brief, 2015
The quantitative proteomics data here reported are part of a research article entitled “Increased acute immune response during the meningo-encephalitic stage of Trypanosoma brucei rhodesiense sleeping sickness compared to Trypanosoma brucei gambiense ...
Natalia Tiberti, Jean-Charles Sanchez
doaj   +1 more source

The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic Human African Trypanosomiasis [PDF]

, 2010
<p><b>Background:</b> <i>Trypanosoma brucei gambiense</i> is the causative agent of chronic Human African Trypanosomiasis or sleeping sickness, a disease endemic across often poor and rural areas of Western and Central ...
Martin A Aslett, Hertz-Fowler Christiane, Chukualim, B., Gibson, W., Melville, S.E., Jackson Andrew P., Jackson, A.P., Jackson, A., Capewell, P., Sanders Mandy, Annette MacLeod, McQuillan, J, Quail, M.A., MacLeod Annette, Melville Sara E., Melville, S., McQuillan, J., Paul Capewell, Aslett Martin A., Bridget Chukualim, MacLeod, A., Aslett, M., Hertz-Fowler, C., McQuillan Jacqueline, Aslett, M.A., Mandy Sanders, Berry Andrew, Michael A Quail, Barry, J.D., Berriman, M., Sanders, M., Wendy Gibson, Sara E Melville, Jacqueline McQuillan, Gibson, WC, Quail Michael A., Berry, A., J David Barry, Andrew P Jackson, Andrew Berry, Christiane Hertz-Fowler, Matthew Berriman, Chukualim Bridget, Gibson Wendy, Barry J. David, Capewell Paul, Berriman Matthew   +46 more
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Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol [PDF]

, 2013
The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. The role of transporters as determinants of drug susceptibility is
Kaiser Marcel, Brun Reto, de Koning Harry P., Patient Pati Pyana, Philippe Büscher, Büscher Philippe, Marcel Kaiser (41510), Mäser, Pascal, Ludin Philipp, Kaiser, Marcel, Büscher, Philippe, Harry P. de Koning (370318), Philipp Ludin, Pascal Mäser (87895), Philipp Ludin (228110), Horn David, Wenzler, Tanja, Tanja Wenzler, Patient Pati Pyana (224071), Graf, Fabrice E., David Horn, Ludin, Philipp, Marcel Kaiser, Pascal Mäser, Pyana, Patient Pati, Horn, David, David Horn (24969), Fabrice E. Graf (469055), Pyana Patient Pati, Philippe Büscher (150731), Fabrice E Graf, Wenzler Tanja, Tanja Wenzler (320253), Horn, David; id_orcid, Brun, Reto, Harry P de Koning, Graf Fabrice E., de Koning, Harry P., Reto Brun, Mäser Pascal, Reto Brun (41511)   +40 more
core   +1 more source