Results 31 to 40 of about 9,952 (165)

Phase II evaluation of sensitivity and specificity of PCR and NASBA followed by oligochromatography for diagnosis of human African trypanosomiasis in clinical samples from D.R. Congo and Uganda. [PDF]

PLoS Neglected Tropical Diseases, 2010
BACKGROUND: The polymerase chain reaction (PCR) and nucleic acid sequence-based amplification (NASBA) have been recently modified by coupling to oligochromatography (OC) for easy and fast visualisation of products.
Enock Matovu, Claire M Mugasa, Rosine Ali Ekangu, Stijn Deborggraeve, George W Lubega, Thierry Laurent, Gerard J Schoone, Henk D Schallig, Philippe Büscher   +8 more
doaj   +1 more source

6-Methyl-7-deazapurine nucleoside analogues as broad-spectrum antikinetoplastid agents

International Journal for Parasitology: Drugs and Drug Resistance, 2021
Kinetoplastid parasites are the causative agents of Chagas disease (CD), leishmaniasis and human African trypanosomiasis (HAT). Despite a sustained decrease in the number of HAT cases, more efforts are needed to discover safe and effective therapies ...
Cai Lin, Fabian Hulpia, Izet Karalic, Laurens De Schepper, Louis Maes, Guy Caljon, Serge Van Calenbergh   +6 more
doaj   +1 more source

Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in tsetse in Serengeti, Tanzania.

PLoS Neglected Tropical Diseases, 2012
BackgroundMeasuring the prevalence of transmissible Trypanosoma brucei rhodesiense in tsetse populations is essential for understanding transmission dynamics, assessing human disease risk and monitoring spatio-temporal trends and the impact of control ...
Harriet K Auty, Kim Picozzi, Imna Malele, Steve J Torr, Sarah Cleaveland, Sue Welburn   +5 more
doaj   +1 more source

Molecular identification of trypanosomes in cattle in Malawi using PCR methods and nanopore sequencing: epidemiological implications for the control of human and animal trypanosomiases

Parasite, 2020
This study aimed to identify trypanosomes infecting cattle in Malawi in order to understand the importance of cattle in the transmission dynamics of Human African Trypanosomiasis (HAT) and Animal African Trypanosomosis (AAT).
Marsela Megasari, Hayashida Kyoko, Nakao Ryo, Chatanga Elisha, Gaithuma Alex Kiarie, Naoko Kawai, Musaya Janelisa, Sugimoto Chihiro, Yamagishi Junya   +8 more
doaj   +1 more source

Artemisinins Inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense In Vitro Growth [PDF]

Antimicrobial Agents and Chemotherapy, 2007
ABSTRACT Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T.
Mishina, Yuliya V., Krishna, Sanjeev, Haynes, Richard K., Meade, John C.   +3 more
openaire   +6 more sources

Genetic diversity and population structure of Trypanosoma brucei in Uganda: implications for the epidemiology of sleeping sickness and Nagana.

PLoS Neglected Tropical Diseases, 2015
BackgroundWhile Human African Trypanosomiasis (HAT) is in decline on the continent of Africa, the disease still remains a major health problem in Uganda.
Richard Echodu, Mark Sistrom, Rosemary Bateta, Grace Murilla, Loyce Okedi, Serap Aksoy, Chineme Enyioha, John Enyaru, Elizabeth Opiyo, Wendy Gibson, Adalgisa Caccone   +10 more
doaj   +1 more source

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman, Janine Aucamp, Helena D. Janse van Rensburg, Christina Kannigadu, Rotondwa Mphephu, Andrew J. Swarts, Keisuke Suganuma, David D. N'Da   +7 more
wiley   +1 more source

Multiorgan Dysfunction Caused by Travel-associated African Trypanosomiasis

Emerging Infectious Diseases, 2012
We describe a case of multiorgan dysfunction secondary to Trypanosoma brucei rhodesiense infection acquired on safari in Zambia. This case was one of several recently reported to ProMED-mail in persons who had traveled to this region.
Lucy E. Cottle, Joanna R. Peters, Alison Hall, J. Wendi Bailey, Harry A. Noyes, Jane E. Rimington, Nicholas J. Beeching, S. Bertel Squire, Mike B.J. Beadsworth   +8 more
doaj   +1 more source

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

Population genetics of Trypanosoma brucei rhodesiense: clonality and diversity within and between foci.

PLoS Neglected Tropical Diseases, 2013
African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development.
Craig W Duffy, Lorna MacLean, Lindsay Sweeney, Anneli Cooper, C Michael R Turner, Andy Tait, Jeremy Sternberg, Liam J Morrison, Annette MacLeod   +8 more
doaj   +1 more source