Results 51 to 60 of about 59,489 (194)

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

Spatially and genetically distinct African trypanosome virulence variants defined by host interferon-g response [PDF]

, 2007
We describe 2 spatially distinct foci of human African trypansomiasis in eastern Uganda. The Tororo and Soroti foci of <i>Trypanosoma brucei rhodesiense</i> infection were genetically distinct as characterized by 6 microsatellite and 1 ...
Kennedy, PGE, Martin Odiit, Cooper, Anneli, MacLeod, A, Peter G. E. Kennedy, Sternberg, JM, Annette MacLeod, Liam Morrison, Odiit, M., Kennedy, Peter G. E., Jeremy M. Sternberg, MacLean, L, Lindsay Sweeney, MacLeod, A., Sweeney, L, MacLeod, Annette, MacLean, L., Odiit, Martin, Morrison, Liam; id_orcid, Sternberg, J.M., Anneli Cooper, Sternberg, Jeremy M., Sweeney, Lindsay, Cooper, A., Odiit, M, Sweeney, L., Cooper, A, Lorna MacLean, MacLean, Lorna, Morrison, L, Kennedy, P.G.E., Morrison, L.   +31 more
core   +1 more source

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe, Vishal Satikuvar, Tanjia M. Syeda, Monica Cal, Pascal Mäser, Marcel Kaiser, Hachemi Kadri   +6 more
wiley   +1 more source

Phytochemical Diversity, Nutritional Values, and Biological Properties of Halopithys incurva (Hudson) Batters, 1902

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Halopithys incurva is a red macroalga distributed across the Mediterranean Sea and North‐East Atlantic, with occasional reports from the Indian Ocean. It exhibits a rich chemical diversity, including isoflavones, bromophenols, MAAs, pigments, phycobiliproteins, primary metabolites, and neuroactive compounds.
Youssra Aalilou, Abdelhakim Bouyahya, Kaoutar Benrahou, Mustapha Hassoun, Hanaa Moussa, Issam Ameziane El Hassani, Waleed Al Abdulmonem, Learn‐Han Lee, Gokhan Zengin, My El Abbes Faouzi   +9 more
wiley   +1 more source

An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei [PDF]

, 2015
Elucidating the mechanism of action of trypanocidal compounds is an important step in the development of more efficient drugs against Trypanosoma brucei. In a screening approach using an RNAi library in T. brucei bloodstream forms, we identified a member
Vial, Henri, Niemann, Moritz, de Macêdo, Juan P., Isabel Roditi, Henri Vial (24552), Moritz Niemann, Mäser, Pascal, Juan P. de Macêdo (735541), Bütikofer, Peter, Barrett, Michael P., Michael P Barrett, Gabriela Schumann Burkard (259590), Pascal Mäser (87895), Peter Bütikofer, Moritz Niemann (735542), Pascal Mäser, Horn, David, André Schneider (74039), Juan P de Macêdo, Isabel Roditi (60386), André Schneider, Roditi, Isabel, Schumann Burkard, Gabriela, Henri Vial, Schneider, André, Schumann-Burkard, Gabriela, Gabriela Schumann Burkard, Michael P. Barrett (167748), Peter Bütikofer (147146)   +28 more
core   +3 more sources

A CASE OF HUMAN AFRICAN TRYPANOSOMIASIS during UNITED NATION MISSION IN LIBERIA

Pakistan Armed Forces Medical Journal, 2011
Human African trypanosomiasis (HAT) or sleeping sickness is caused by Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense, and is endemic/epidemic in many countries of Africa1.
Muhammad Ayub, S Aamir Shah, Muhammad Irfan, Junaid Afsar Khan   +3 more
doaj   +2 more sources

PLS-Prediction and Confirmation of Hydrojuglone Glucoside as the Antitrypanosomal Constituent of Juglans Spp.

Molecules, 2015
Naphthoquinones (NQs) occur naturally in a large variety of plants. Several NQs are highly active against protozoans, amongst them the causative pathogens of neglected tropical diseases such as human African trypanosomiasis (sleeping sickness), Chagas ...
Therese Ellendorff, Reto Brun, Marcel Kaiser, Jandirk Sendker, Thomas J. Schmidt   +4 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, Volume 600, Issue 5, Page 591-611, March 2026.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Safety and efficacy of the 10-day melarsoprol schedule for the treatment of second stage rhodesiense sleeping sickness [PDF]

, 2012
OBJECTIVE: Assessment of the safety and efficacy of a 10-day melarsoprol schedule in second stage T.b. rhodesiense patients and the effect of suramin-pretreatment on the incidence of encephalopathic syndrome (ES) during melarsoprol therapy.
Schmid, C., Mpairwe Allan (141217), Mpairwe Allan, Schmid, Caecilia, Christian Burri, Allan, M., Haary Emma P., Kibona, S., Kibona, Stafford, Andrew Edielu, Kakembo, A., Irene Kuepfer, Blum Johannes, Edielu, Andrew, Emma P Haary, Johannes Blum, Emma P. Haary (141226), Allan, Mpairwe, Blum, Johannes, Schmid Caecilia, Stafford Kibona (141235), Haary, Emma P, Caecilia Schmid (141212), Christian Burri (141244), Abbas Kakembo, Abbas Kakembo (141232), Burri, C., Edielu, A., Caecilia Schmid, Johannes Blum (141240), Blum, J., Burri Christian, Kuepfer, Irene, Stafford Kibona, Kuepfer Irene, Burri, Christian, Kakembo, Abbas, Kakembo Abbas, Küpfer, I., Andrew Edielu (141221), Haary, E. P., Allan Mpairwe, Edielu Andrew, Irene Kuepfer (141207), Kibona Stafford   +44 more
core   +1 more source

Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection

mBio, 2016
African trypanosomes, except Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, which cause human African trypanosomiasis, are lysed by the human serum protein apolipoprotein L1 (ApoL1).
Bart Cuypers, Laurence Lecordier, Conor J. Meehan, Frederik Van den Broeck, Hideo Imamura, Philippe Büscher, Jean-Claude Dujardin, Kris Laukens, Achim Schnaufer, Caroline Dewar, Michael Lewis, Oliver Balmer, Thomas Azurago, Sardick Kyei-Faried, Sally-Ann Ohene, Boateng Duah, Prince Homiah, Ebenezer Kofi Mensah, Francis Anleah, Jose Ramon Franco, Etienne Pays, Stijn Deborggraeve   +21 more
doaj   +1 more source