Results 71 to 80 of about 9,952 (165)

Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

Pharmaceuticals, 2016
A series of 15 alkanediamide-linked bisbenzamidines and related analogs was synthesized and tested in vitro against two Trypanosoma brucei (T.b.) subspecies: T.b. brucei and T.b.
Jean J. Vanden Eynde, Annie Mayence, Madhusoodanan Mottamal, Cyrus J. Bacchi, Nigel Yarlett, Marcel Kaiser, Reto Brun, Tien L. Huang   +7 more
doaj   +1 more source

Characterisation of the wildlife reservoir community for human and animal trypanosomiasis in the Luangwa Valley, Zambia.

PLoS Neglected Tropical Diseases, 2011
BackgroundAnimal and human trypanosomiasis are constraints to both animal and human health in Sub-Saharan Africa, but there is little recent evidence as to how these parasites circulate in wild hosts in natural ecosystems.
Neil E Anderson, Joseph Mubanga, Eric M Fevre, Kim Picozzi, Mark C Eisler, Robert Thomas, Susan C Welburn   +6 more
doaj   +1 more source

High frequency of antigenic variation inTrypanosoma brucei rhodesienseinfections

Parasitology, 1989
SUMMARYRates at whichTrypanosoma bruceirhodesiense trypanosomes switch from expression of one variable antigen type (VAT) to that of another have been determined in cloned populations that have been recently tsetse-fly transmitted. Switching rates have been determined between several, specific pairs of VATs in each population.
C M, Turner, J D, Barry
openaire   +2 more sources

Development of a safer laboratory vervet monkey model for the study of human African trypanosomiasis

African Journal of Laboratory Medicine, 2014
Background: There are three subspecies of Trypanosoma brucei: T. b. gambiense, T. b. rhodesiense and T. b. brucei. The first two are infectious to humans, whilst T. b. brucei is not. Identifying an animal model of T. b.
Maxwell Waema, Naomi Maina, Simon Karanja, Beatrice Gachie, Maina Ngotho, John Kagira   +5 more
doaj   +1 more source

Dipeptide Nitrile CD34 with Curcumin: A New Improved Combination Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense. [PDF]

Int J Mol Sci, 2023
Di Chio C, Previti S, Totaro N, De Luca F, Allegra A, Schirmeister T, Zappalà M, Ettari R.   +7 more
europepmc   +1 more source

Factors associated with acquisition of human infective and animal infective trypanosome infections in domestic livestock in Western Kenya.

PLoS Neglected Tropical Diseases, 2011
BackgroundTrypanosomiasis is regarded as a constraint on livestock production in Western Kenya where the responsibility for tsetse and trypanosomiasis control has increasingly shifted from the state to the individual livestock owner.
Beatrix von Wissmann, Noreen Machila, Kim Picozzi, Eric M Fèvre, Barend M deC Bronsvoort, Ian G Handel, Susan C Welburn   +6 more
doaj   +1 more source

Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents

Marine Drugs, 2013
Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC50 3.1 μM) and Plasmodium falciparum (K1 dual drug resistant ...
Marcel Kaiser, Brent R. Copp, A. Norrie Pearce, Shen H. Tan, Cary F. C. Lam   +4 more
doaj   +1 more source

<i>Trypanosoma brucei rhodesiense</i> Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response. [PDF]

Int J Mol Sci, 2022
Costa TFR, Goundry A, Morrot A, Grab DJ, Mottram JC, Lima APCA.   +5 more
europepmc   +1 more source

Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense. [PDF]

Int J Mol Sci, 2022
Di Chio C, Previti S, De Luca F, Bogacz M, Zimmer C, Wagner A, Schirmeister T, Zappalà M, Ettari R.   +8 more
europepmc   +1 more source

Mouse experiments demonstrate differential pathogenicity and virulence of Trypanosoma brucei rhodesiense strains. [PDF]

Exp Parasitol, 2021
Kipkorir LW, John TK, Owino OB, John O, Robert S, Daniel M, Owino AV.   +6 more
europepmc   +1 more source