Results 71 to 80 of about 14,283 (207)

Determination of the prevalence of African trypanosome species in indigenous dogs of Mambwe district, eastern Zambia, by loop-mediated isothermal amplification

Parasites & Vectors, 2014
Background Dogs have been implicated to serve as links for parasite exchange between livestock and humans and remain an important source of emerging and re-emerging diseases including trypanosome infections.
Malimba Lisulo, Chihiro Sugimoto, Kiichi Kajino, Kyouko Hayashida, Macarthy Mudenda, Ladslav Moonga, Joseph Ndebe, Selestine Nzala, Boniface Namangala   +8 more
doaj   +1 more source

Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1. [PDF]

PLoS Pathogens, 2018
In contrast to Trypanosoma brucei gambiense and T. b. rhodesiense (the causative agents of human African trypanosomiasis), T. b. brucei is lysed by apolipoprotein-L1 (apoL1)-containing human serum trypanolytic factors (TLF), rendering it non-infectious ...
Rachel B Currier, Anneli Cooper, Hollie Burrell-Saward, Annette MacLeod, Sam Alsford   +4 more
doaj   +1 more source

Control of Human African Trypanosomiasis in the Nola‐Bilolo Focus, Central African Republic, 2020–2024: Outcome of Capacity Building, Improved Diagnosis and Treatment

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
This study is aimed at evaluating the inclusion of miniature anion‐exchange centrifugation technique (mAECT) in the diagnosis and fexinidazole as treatment of gHAT in Central African Republic (CAR) after capacity building. A cross‐sectional pilot study was conducted during a mass diagnostic campaign from 16 September to 22 October 2022 in Nola‐Bilolo ...
Pierre-Marie Douzima, Mireille Cornelia Ingrid Denissio Morissi Nalingbo, Yvon Andjingbopou, Veerle Lejon, Romaric Nzoumbou-Boko, José F. Silveira   +5 more
wiley   +1 more source

Salivarian Trypanosomes Have Adopted Intricate Host-Pathogen Interaction Mechanisms That Ensure Survival in Plain Sight of the Adaptive Immune System

Pathogens, 2021
Salivarian trypanosomes are extracellular parasites affecting humans, livestock and game animals. Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense are human infective sub-species of T.
Stefan Magez, Joar Esteban Pinto Torres, Seoyeon Oh, Magdalena Radwanska   +3 more
doaj   +1 more source

The trypanosomal transferrin receptor of trypanosoma brucei : a review [PDF]

, 2019
Iron is an essential element for life. Its uptake and utility requires a careful balancing with its toxic capacity, with mammals evolving a safe and bio-viable means of its transport and storage. This transport and storage is also utilized as part of the
Kariuki, Christopher K., Magez, Stefan, Stijlemans, Benoit   +2 more
core   +2 more sources

Impact of long‐term mass‐rearing on the genetic structure of tsetse fly Glossina palpalis gambiensis colonies

Insect Science, Volume 32, Issue 5, Page 1575-1587, October 2025.
Abstract Tsetse flies are the sole cyclic vectors of African trypanosomes, which cause human and animal African trypanosomiases in Africa. Tsetse fly control remains a promising option for disease management. The sterile insect technique (SIT) stands as an environmentally friendly tool to control tsetse populations.
Kiswend‐sida M. Dera, Soumaïla Pagabeleguem, Tito Tresor Melachio Tanekou, Ange Irénée Toé, Gisèle Marie Sophie Ouedraogo‐Sanou, Adrien Marie Gaston Belem, Sophie Ravel, Robert L. Mach, Marc J. B. Vreysen, Adly M.M. Abd‐Alla   +9 more
wiley   +1 more source

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, Volume 32, Issue 5, Page 1747-1760, October 2025.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

Novel African trypanocidal agents: membrane rigidifying peptides [PDF]

, 2012
The bloodstream developmental forms of pathogenic African trypanosomes are uniquely susceptible to killing by small hydrophobic peptides. Trypanocidal activity is conferred by peptide hydrophobicity and charge distribution and results from increased ...
Andreas Hartel, Annette MacLeod, Chris Scelsi, John M. Harrington, Markus Engstler, Nicola G. Jones, Paul Capewell, Stephen Hajduk, Sylvie Bisser   +8 more
core   +3 more sources

Potential of entomopathogenic fungi for Glossina austeni control: insights into microbiome alterations and implications on sustainable management of the pest

Insect Science, Volume 32, Issue 5, Page 1691-1712, October 2025.
Abstract Glossina austeni Newstead (Diptera: Glossinidae) is a competent vector of the trypanosomes causing human African trypanosomiasis and the African animal trypanosomosis. Management of this pest has primarily involved trapping methods, Sterile Insect Technique, and research into vector competence–symbiotic interactions.
Fidelis Levi Odhiambo Ombura, Imna Malele, Adly MM Abd‐Alla, Komivi Senyo Akutse, Inusa Jacob Ajene, Fathiya Mbarak Khamis   +5 more
wiley   +1 more source

Reanalyzing the 1900–1920 Sleeping Sickness Epidemic in Uganda

Emerging Infectious Diseases, 2004
Sleeping sickness has long been a major public health problem in Uganda. From 1900 to 1920, more than 250,000 people died in an epidemic that affected the southern part of the country, particularly the Busoga region.
E.M. Fèvre, P.G. Coleman, S.C. Welburn, I. Maudlin   +3 more
doaj   +1 more source