Plasma neuronal specific enolase : a potential stage diagnostic marker in human African trypanosomiasis [PDF]
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Mitchell, Julia A, Sternberg, Jeremy M
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Abstract Tsetse flies (Glossina spp.) can vector the parasites (Trypanosoma spp.) that cause the socioeconomically devastating neglected tropical diseases human and animal African trypanosomoses. In addition to this parasite, tsetse can harbor four genera of endosymbiotic bacteria, including Wigglesworthia, Sodalis, Wolbachia, and Spiroplasma, which ...
Kiswend‐sida M. Dera +14 more
wiley +1 more source
New tsetse (Glossina fuscipes fuscipes) genomes generated from wild and laboratory‐reared specimens
Abstract Tsetse (Glossina spp.) are vectors of African trypanosomes that cause devastating human and animal African trypanosomiases. While much of the research to better understand tsetse genetics and physiology relies on colony‐reared flies, these flies may not represent the genetic diversity found in natural wild populations due to their long‐term ...
Daniel J. Bruzzese +5 more
wiley +1 more source
Quantitative Structure ‒ Antiprotozoal Activity Relationships of Sesquiterpene Lactones
Prompted by results of our previous studies where we found high activity of some sesquiterpene lactones (STLs) against Trypanosoma brucei rhodesiense (which causes East African sleeping sickness), we have now conducted a structure-(in-vitro)-activity ...
Reto Brun +4 more
doaj +1 more source
In Vitro Leishmanicidal Efficacy of Synthesized Arylidene Analogues of Glitazone
ABSTRACT Diabetes is a fast‐growing health issue in low‐ and middle‐income countries, with ~80% of diabetics living in the tropics and sub‐tropics. It is a deadly condition claiming the lives of millions of individuals annually, with no therapeutic treatment available to date. The management of diabetes is thus limited to symptomatic relief by glycemic
Janine Aucamp +4 more
wiley +1 more source
Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis [PDF]
BACKGROUND: Control and elimination of human African trypanosomiasis (HAT) can be accelerated through the use of diagnostic tests that are more accurate and easier to deploy.
Albertini, A +20 more
core +15 more sources
The Burden of Neglected Tropical Diseases in Rwanda: A Scoping Review
ABSTRACT Background and Aims Rwanda is among the African countries affected by neglected tropical diseases (NTDs). This scoping review aims to synthesize available information to understand the prevalence, incidence, distribution, morbidity, mortality, and risk factors of NTDs in Rwanda.
Masceline Jenipher Mutsaka‐Makuvaza +9 more
wiley +1 more source
Chemical Constituents From the Ethyl Acetate Extract of
One new triterpenoid, 3β- O -(2-hydroxybenzoyl)-ursolic acid ( 1 ), and 11 known compounds, including 5 triterpenoids, 2 steroidal compounds, and 4 phenolic compounds were isolated from the ethyl acetate extract of the aerial parts of Salvia hydrangea ...
Majid B. Kahnamoei +5 more
doaj +1 more source
Estimating the burden of rhodesiense sleeping sickness during an outbreak in Serere, eastern Uganda
Background Zoonotic sleeping sickness, or HAT (Human African Trypanosomiasis), caused by infection with Trypanosoma brucei rhodesiense, is an under-reported and neglected tropical disease.
Coleman Paul G +4 more
doaj +1 more source
Nanobodies as tools to understand, diagnose, and treat African trypanosomiasis [PDF]
African trypanosomes are strictly extracellular protozoan parasites that cause diseases in humans and livestock and significantly affect the economic development of sub-Saharan Africa.
Caljon, Guy +5 more
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