Results 81 to 90 of about 59,489 (194)

Quantitative Structure ‒ Antiprotozoal Activity Relationships of Sesquiterpene Lactones

Molecules, 2009
Prompted by results of our previous studies where we found high activity of some sesquiterpene lactones (STLs) against Trypanosoma brucei rhodesiense (which causes East African sleeping sickness), we have now conducted a structure-(in-vitro)-activity ...
Reto Brun, Sami A. Khalid, Marcel Kaiser, Thomas J. Schmidt, Amal M. M. Nour   +4 more
doaj   +1 more source

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, Volume 32, Issue 5, Page 1747-1760, October 2025.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism [PDF]

, 2013
Recently, we reported on a new class of naphthoquinone derivatives showing a promising anti-trypanosomatid profile in cell-based experiments. The lead of this series (B6, 2-phenoxy-1,4-naphthoquinone) showed an ED(50) of 80 nM against Trypanosoma brucei ...
Mazet Muriel, Muriel Mazet, Scapozza, L., Brun Reto, Bakker, Barbara M.; id_orcid, Leonardo Scapozza (102177), Leonardo Scapozza, Bergamini Christian, Remo Perozzo, Federica Prati, Bakker Barbara M., Bergamini, C., Barbara M. Bakker, Haanstra, J.R.; id_orcid, Cavalli Andrea, Capranico, G., Bakker, B.M., Jurgen R Haanstra, Mazet, M., Bakker, Barbara M., Haanstra, J.R., Capranico, Giovanni, Pieretti, S., Giovanni Capranico (102150), Haanstra, Jurgen R., Lenaz Giorgio, Bakker, Barbara M, Romana Fato (102127), Jurgen R. Haanstra, Michels, Paulus, Jurgen R. Haanstra (102071), Andrea Cavalli, Perozzo, Remo, Bergamini, Christian, Bolognesi, M.L., Pieretti, Simone, Reto Brun, Reto Brun (41511), Brun, R., Bolognesi Maria Laura, Fato, Romana, Perozzo, R., Simone Pieretti, Andrea Cavalli (102196), Giovanni Capranico, Michels, Paul A. M., Lenaz, G., Christian Bergamini (102106), Paul A. M. Michels, Scapozza Leonardo, Remo Perozzo (102094), Haanstra, Jurgen R, Muriel Mazet (102083), Giorgio Lenaz, Giorgio Lenaz (102138), Fato, R., Prati, Federica, Maria Laura Bolognesi, Barbara M. Bakker (102159), Cavalli, Andrea, Paul A M Michels, Pieretti Simone, Barbara M Bakker, Lenaz, Giorgio, Perozzo Remo, Prati, F., Michels Paul A. M., Haanstra Jurgen R., Christian Bergamini, Fato Romana, Michels, P.A.M., Paul A. M. Michels (102168), Romana Fato, Brun, Reto, Bolognesi, Maria Laura, Cavalli, A., Mazet, Muriel, Scapozza, Leonardo, Simone Pieretti (102060), Prati Federica, Maria Laura Bolognesi (102185), Capranico Giovanni, Federica Prati (102117)   +82 more
core   +3 more sources

Potential of entomopathogenic fungi for Glossina austeni control: insights into microbiome alterations and implications on sustainable management of the pest

Insect Science, Volume 32, Issue 5, Page 1691-1712, October 2025.
Abstract Glossina austeni Newstead (Diptera: Glossinidae) is a competent vector of the trypanosomes causing human African trypanosomiasis and the African animal trypanosomosis. Management of this pest has primarily involved trapping methods, Sterile Insect Technique, and research into vector competence–symbiotic interactions.
Fidelis Levi Odhiambo Ombura, Imna Malele, Adly MM Abd‐Alla, Komivi Senyo Akutse, Inusa Jacob Ajene, Fathiya Mbarak Khamis   +5 more
wiley   +1 more source

Chemical Constituents From the Ethyl Acetate Extract of

Natural Product Communications, 2019
One new triterpenoid, 3β- O -(2-hydroxybenzoyl)-ursolic acid ( 1 ), and 11 known compounds, including 5 triterpenoids, 2 steroidal compounds, and 4 phenolic compounds were isolated from the ethyl acetate extract of the aerial parts of Salvia hydrangea ...
Majid B. Kahnamoei, Marzieh Tabefam, Samad N. Ebrahimi, Ombeline Danton, Matthias Hamburger, Mahdi M. Farimani   +5 more
doaj   +1 more source

Estimating the burden of rhodesiense sleeping sickness during an outbreak in Serere, eastern Uganda

BMC Public Health, 2008
Background Zoonotic sleeping sickness, or HAT (Human African Trypanosomiasis), caused by infection with Trypanosoma brucei rhodesiense, is an under-reported and neglected tropical disease.
Coleman Paul G, Odiit Martin, Fèvre Eric M, Woolhouse Mark EJ, Welburn Susan C   +4 more
doaj   +1 more source

Dynamical and optimal control analysis of a seasonal Trypanosoma brucei rhodesiense model

Mathematical biosciences and engineering : MBE, 2020
Los efectos de las variaciones estacionales en la epidemiología de la enfermedad por Trypanosoma brucei rhodesiense están bien documentados. En particular, las variaciones estacionales alteran las tasas de desarrollo y el comportamiento de los vectores, lo que influye en la dinámica de transmisión de la enfermedad. En este trabajo se presenta un modelo
Mlyashimbi Helikumi, Moatlhodi Kgosimore, Dmitry Kuznetsov, Steady Mushayabasa   +3 more
openaire   +3 more sources

Epidemiology of human African trypanosomiasis

Clinical Epidemiology, 2014
Jose R Franco,1 Pere P Simarro,1 Abdoulaye Diarra,2 Jean G Jannin1 1World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland; 2World Health Organization, Inter Country Support ...
Franco JR, Simarro PP, Diarra A, Jannin JG   +3 more
doaj  

Antiprotozoal Activity of Extracts of five Turkish Lamiaceae Species

Natural Product Communications, 2011
The in vitro antiprotozoal activities of crude methanolic extracts from the aerial parts of five Lamiaceae plants ( Salvia tomentosa, S. sclarea, S. dichroantha, Nepeta nuda subsp. nuda and Marrubium astracanicum subsp.
Hasan Kirmizibekmez, Irem Atay, Marcel Kaiser, Erdem Yesilada, Deniz Tasdemir   +4 more
doaj   +1 more source

Antigenic variation in African trypanosomes [PDF]

, 2014
Studies on Variant Surface Glycoproteins (VSGs) and antigenic variation in the African trypanosome, Trypanosoma brucei, have yielded a remarkable range of novel and important insights. The features first identified in T.
Horn, David; id_orcid
core   +1 more source