An Overview of Trypanosoma brucei Infections: An Intense Host–Parasite Interaction [PDF]
, 2016 Trypanosoma brucei rhodesiense and T. brucei gambiense, the causative agents of Human African Trypanosomiasis, are transmitted by tsetse flies. Within the vector, the parasite undergoes through transformations that prepares it to infect the human host ...
Alicia Ponte-Sucre
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A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense.
PLoS Neglected Tropical Diseases, 2016 Humans are protected against infection from most African trypanosomes by lipoprotein complexes present in serum that contain the trypanolytic pore-forming protein, Apolipoprotein L1 (APOL1).
Anneli Cooper +7 more
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PLoS Neglected Tropical Diseases, 2011 BackgroundAnimal and human trypanosomiasis are constraints to both animal and human health in Sub-Saharan Africa, but there is little recent evidence as to how these parasites circulate in wild hosts in natural ecosystems.
Neil E Anderson +6 more
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Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms of African trypanosomes [PDF]
, 1994 Successful transmission of the African trypanosome between the mammalian host blood-stream and the tsetse fly vector involves dramatic alterations in the parasite's morphology and biochemistry.
Gull, K, Matthews, K R
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High frequency of antigenic variation inTrypanosoma brucei rhodesienseinfections
Parasitology, 1989 SUMMARYRates at whichTrypanosoma bruceirhodesiense trypanosomes switch from expression of one variable antigen type (VAT) to that of another have been determined in cloned populations that have been recently tsetse-fly transmitted. Switching rates have been determined between several, specific pairs of VATs in each population.
C M, Turner, J D, Barry
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The effect of normal human serum on the mouse trypanosome Trypanosoma musculi in vitro and in vivo [PDF]
, 2018 Trypanosoma musculi, a common blood flagellate found in mice, is similar in morphology and life cycle to the rat trypanosome T. lewisi. Both species belong to the subgenus Herpetosoma, and as T.
Hide, G +6 more
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Development of a safer laboratory vervet monkey model for the study of human African trypanosomiasis
African Journal of Laboratory Medicine, 2014 Background: There are three subspecies of Trypanosoma brucei: T. b. gambiense, T. b. rhodesiense and T. b. brucei. The first two are infectious to humans, whilst T. b. brucei is not. Identifying an animal model of T. b.
Maxwell Waema +5 more
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PLoS Neglected Tropical Diseases, 2011 BackgroundTrypanosomiasis is regarded as a constraint on livestock production in Western Kenya where the responsibility for tsetse and trypanosomiasis control has increasingly shifted from the state to the individual livestock owner.
Beatrix von Wissmann +6 more
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Dipeptide Nitrile CD34 with Curcumin: A New Improved Combination Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense. [PDF]
Int J Mol Sci, 2023 Di Chio C +7 more
europepmc +1 more source
Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents
Marine Drugs, 2013 Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC50 3.1 μM) and Plasmodium falciparum (K1 dual drug resistant ...
Marcel Kaiser +4 more
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