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Will the real Trypanosoma brucei rhodesiense please step forward?
Trends in Parasitology, 2002The sleeping sickness trypanosomes Trypanosoma brucei rhodesiense and T. brucei gambiense are morphologically indistinguishable from each other and from T. brucei brucei, which does not infect humans. The relationships between these three subspecies have been controversial. Several years ago, the characterization of T.
Wendy Gibson
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Archives of Biochemistry and Biophysics, 2000
Methionine is an essential amino acid for both prokaryotic and eukaryotic organisms; however, little is known concerning its utilization in African trypanosomes, protozoa of the Trypanosoma brucei group. This study explored the Michaelis-Menten kinetic constants for transport and pool formation as well as metabolic utilization of methionine by two ...
B, Goldberg +4 more
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Methionine is an essential amino acid for both prokaryotic and eukaryotic organisms; however, little is known concerning its utilization in African trypanosomes, protozoa of the Trypanosoma brucei group. This study explored the Michaelis-Menten kinetic constants for transport and pool formation as well as metabolic utilization of methionine by two ...
B, Goldberg +4 more
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European Journal of Medicinal Chemistry, 2021
Human African Trypanosomiasis (HAT) is a neglected tropical disease caused by the parasitic protozoan Trypanosoma brucei (T. b.), and affects communities in sub-Saharan Africa. Previously, analogues of a tetrahydroisoquinoline scaffold were reported as having in vitro activity (IC50 = 0.25-70.5 μM) against T. b. rhodesiense. In this study the synthesis
Danica R. Cullen +9 more
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Human African Trypanosomiasis (HAT) is a neglected tropical disease caused by the parasitic protozoan Trypanosoma brucei (T. b.), and affects communities in sub-Saharan Africa. Previously, analogues of a tetrahydroisoquinoline scaffold were reported as having in vitro activity (IC50 = 0.25-70.5 μM) against T. b. rhodesiense. In this study the synthesis
Danica R. Cullen +9 more
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The effect of spiroarsoranes on Trypanosoma brucei brucei and T. b. rhodesiense
Parasitology Research, 1996Topical application and intraperitoneal administration of spiroarsoranes were carried out to cure central nervous system (CNS) trypanosomiasis in the chronic Trypanosoma brucei GVR 35 mouse model. Topical application appeared more efficient than intraperitoneal injection. The periods of aparasitaemia after treatment were longer but none of the mice was
P M, Loiseau +3 more
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The action of trypanocidal arsenical drugs on Trypanosoma brucei and Trypanosoma rhodesiense
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1974Abstract 1. 1. Catabolism of glucose by monomorphic Trypanosoma brucei and pleomorphic T. rhodesiense is inhibited by trivalent organic arsenicals. The utilization of α-oxoglutarate and pyruvate by short stumpy forms of pleomorphic T. rhodesiense is inhibited by similar concentrations of arsenicals. 2. 2.
I W, Flynn, I B, Bowman
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Planta Medica, 1999
Dichloromethane extracts of the root bark and stem bark of Kigelia pinnata collected from Zimbabwe exhibited antitrypanosomal activity against Trypanosoma brucei brucei in vitro. Activity-guided fractionation led to the isolation of four naphthoquinones from both the root and stem bark of the plant.
S V, Moideen +4 more
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Dichloromethane extracts of the root bark and stem bark of Kigelia pinnata collected from Zimbabwe exhibited antitrypanosomal activity against Trypanosoma brucei brucei in vitro. Activity-guided fractionation led to the isolation of four naphthoquinones from both the root and stem bark of the plant.
S V, Moideen +4 more
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Experimental infection of cattle with Trypanosoma brucei rhodesiense
Annals of Tropical Medicine & Parasitology, 1989Infection of cattle with various stocks of Trypanosoma brucei rhodesiense indicated that 49% developed a fatal CNS disease comparable to that found in man. Duration of disease ranged from 85 to 1613 days post infection. All eight stocks of T. b. rhodesiense tested, including those from Ethiopia and Tanzania, induced CNS disease.
B T, Wellde +7 more
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Expression site associated genes of Trypanosoma brucei rhodesiense
Molecular and Biochemical Parasitology, 1989Upstream of at least some telomere-linked genes for the variant surface glycoproteins (VSGs) of African trypanosomes are expression site associated genes (ESAGs) whose transcription is co-ordinated with the transcription of the adjacent VSG gene [Cully et al. (1985) Cell 42, 173-182]. The function of the corresponding ESAG proteins is not known.
H J, Son +3 more
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Growth of Pleomorphic Trypanosoma brucei rhodesiense in Irradiated Inbred Mice
The Journal of Parasitology, 1988It was shown that irradiation (650 rad) of 7 inbred strains of mice did not block the ability of Trypanosoma brucei rhodesiense to transform from the long slender (LS) to the short stumpy (SS) form or alter the plateau in parasitemia. In addition, it was observed that significant differences in parasitemia levels, in the rate of transformation from the
J R, Seed, J, Sechelski
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Electrocardiographic changes in African trypanosomiasis caused by Trypanosoma brucei rhodesiense
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1975The electrocardiographic findings in 40 patients with Trypanosoma brucei rhodesiense infection are reported. Using rigid diagnostic criteria 7 out of 18 patients (39%) had abnormal electrocardiograms before any form of therapy and 22 of the 40 patients (55%) had abnormal electrocardiograms at some stage of the disease or its treatment.
I G, Jones, M N, Lowenthal, H, Buyst
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