Results 111 to 120 of about 14,283 (207)

<i>Trypanosoma brucei rhodesiense</i> Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response. [PDF]

Int J Mol Sci, 2022
Costa TFR, Goundry A, Morrot A, Grab DJ, Mottram JC, Lima APCA.   +5 more
europepmc   +1 more source

Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense. [PDF]

Int J Mol Sci, 2022
Di Chio C, Previti S, De Luca F, Bogacz M, Zimmer C, Wagner A, Schirmeister T, Zappalà M, Ettari R.   +8 more
europepmc   +1 more source

Mouse experiments demonstrate differential pathogenicity and virulence of Trypanosoma brucei rhodesiense strains. [PDF]

Exp Parasitol, 2021
Kipkorir LW, John TK, Owino OB, John O, Robert S, Daniel M, Owino AV.   +6 more
europepmc   +1 more source

Plasma cytokines quantification among Trypanosoma brucei rhodesiense sleeping sickness cases and controls in Rumphi, Malawi. [PDF]

Malawi Med J, 2021
Kamoto K, Chiwaya A, Nambala P, Chammudzi P, Senga E, Chisi J, Matovu E, Musaya J.   +7 more
europepmc   +1 more source

Molecular docking to homology models of human and Trypanosoma brucei ERK8 that identified ortholog-specific inhibitors.

PLoS Neglected Tropical Diseases
Human African Trypanosomiasis (HAT), also known as sleeping sickness, is a lethal disease caused by two vector-borne parasites: Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense. The limited number of antitrypanosomal therapies for treating
Matthew Merski, Zachary B Mackey
doaj   +1 more source

Coenzyme Q₁₀ prevented Trypanosoma brucei rhodesiense-mediated breach of the blood brain barrier, inflammation and organ damage in late stage of Human African Trypanosomiasis. [PDF]

J Parasit Dis, 2023
Kitwan L, Makobe C, Mdachi R, Maranga DN, Isaac AO, Nyariki JN.   +5 more
europepmc   +1 more source

Plasma Neuron-Specific Enolase is not a reliable biomarker for staging Trypanosoma brucei rhodesiense sleeping sickness patients. [PDF]

BMC Res Notes, 2022
Kato CD, Twesigye D, Alibu VP, Nanteza A, Nsubuga J, Mugasa CM, Matovu E.   +6 more
europepmc   +1 more source

GSK-3 kinase a putative therapeutic target in trypanosomatid parasites

Brazilian Journal of Infectious Diseases
Trypanosomatids are an important group of parasites that predominate in tropical and subtropical areas of the planet, which cause diseases that are classified as forgotten and neglected by the world health organization.
Alfredo Prado Diaz, Cristian Alejandro Meneses Canal, Alvaro José Valdés, Jaider Elian Giraldo Delgado, RE Varela-M   +4 more
doaj   +1 more source

Salvia officinalis L.: Antitrypanosomal Activity and Active Constituents against Trypanosoma brucei rhodesiense. [PDF]

Molecules, 2021
Llurba Montesino N, Kaiser M, Mäser P, Schmidt TJ.   +3 more
europepmc   +1 more source

Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host. [PDF]

PLoS Negl Trop Dis, 2021
Levy DJ, Goundry A, Laires RSS, Costa TFR, Novo CM, Grab DJ, Mottram JC, Lima APCA.   +7 more
europepmc   +1 more source