Results 91 to 100 of about 59,489 (194)

A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense.

PLoS Neglected Tropical Diseases, 2016
Humans are protected against infection from most African trypanosomes by lipoprotein complexes present in serum that contain the trypanolytic pore-forming protein, Apolipoprotein L1 (APOL1).
Anneli Cooper, Paul Capewell, Caroline Clucas, Nicola Veitch, William Weir, Russell Thomson, Jayne Raper, Annette MacLeod   +7 more
doaj   +1 more source

Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

Pharmaceuticals, 2016
A series of 15 alkanediamide-linked bisbenzamidines and related analogs was synthesized and tested in vitro against two Trypanosoma brucei (T.b.) subspecies: T.b. brucei and T.b.
Jean J. Vanden Eynde, Annie Mayence, Madhusoodanan Mottamal, Cyrus J. Bacchi, Nigel Yarlett, Marcel Kaiser, Reto Brun, Tien L. Huang   +7 more
doaj   +1 more source

Allelic segregation and independent assortment in T. brucei crosses: proof that the genetic system is Mendelian and involves meiosis [PDF]

, 2005
The genetic system on Trypanosoma brucei has been analysed by generating large numbers of independent progeny clones from two crosses, one between two cloned isolates of Trypanosoma brucei brucei and one between cloned isolates of T. b.
Turner, CMR, MacLeod, A, Taylor, S, Taylor, S., McLellan, S, Cooper, A., Sweeney, L., Turner, C.M.R., Cooper, A, Tweedie, A., Tait, A., Tait, A, MacLeod, A., Sweeney, L, McLellan, S., Tweedie, A   +15 more
core   +1 more source

Characterisation of the wildlife reservoir community for human and animal trypanosomiasis in the Luangwa Valley, Zambia.

PLoS Neglected Tropical Diseases, 2011
BackgroundAnimal and human trypanosomiasis are constraints to both animal and human health in Sub-Saharan Africa, but there is little recent evidence as to how these parasites circulate in wild hosts in natural ecosystems.
Neil E Anderson, Joseph Mubanga, Eric M Fevre, Kim Picozzi, Mark C Eisler, Robert Thomas, Susan C Welburn   +6 more
doaj   +1 more source

Dipeptide Nitrile CD34 with Curcumin: A New Improved Combination Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense. [PDF]

Int J Mol Sci, 2023
Di Chio C, Previti S, Totaro N, De Luca F, Allegra A, Schirmeister T, Zappalà M, Ettari R.   +7 more
europepmc   +1 more source

Characterization of Trypanosoma brucei gambiense variant surface glycoprotein LiTat 1.5 [PDF]

, 2012
At present, all available diagnostic antibody detection tests for Trypanosoma brucei gambiense human African trypanosomiasis are based on predominant variant surface glycoproteins (VSGs), such as VSG LiTat 1.5. During investigations aiming at replacement
Rogé, S., Lejon, V., Guisez, Y., Guisez, Yves, Van Nieuwenhove, L., Büscher, P., Rog\ue9, S.   +6 more
core   +1 more source

High frequency of antigenic variation inTrypanosoma brucei rhodesienseinfections

Parasitology, 1989
SUMMARYRates at whichTrypanosoma bruceirhodesiense trypanosomes switch from expression of one variable antigen type (VAT) to that of another have been determined in cloned populations that have been recently tsetse-fly transmitted. Switching rates have been determined between several, specific pairs of VATs in each population.
C M, Turner, J D, Barry
openaire   +2 more sources

Development of a safer laboratory vervet monkey model for the study of human African trypanosomiasis

African Journal of Laboratory Medicine, 2014
Background: There are three subspecies of Trypanosoma brucei: T. b. gambiense, T. b. rhodesiense and T. b. brucei. The first two are infectious to humans, whilst T. b. brucei is not. Identifying an animal model of T. b.
Maxwell Waema, Naomi Maina, Simon Karanja, Beatrice Gachie, Maina Ngotho, John Kagira   +5 more
doaj   +1 more source

<i>Trypanosoma brucei rhodesiense</i> Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response. [PDF]

Int J Mol Sci, 2022
Costa TFR, Goundry A, Morrot A, Grab DJ, Mottram JC, Lima APCA.   +5 more
europepmc   +1 more source

Characterization of a PKA-like kinase from Trypanosoma brucei [PDF]

, 2005
The protozoan parasite Trypanosoma brucei causes human sleeping sickness and Nagana in domestic animals and depends on the tsetse fly for dissemination. The complex T.
Kramer, Susanne
core   +1 more source