Results 11 to 20 of about 59,489 (194)

Development of Novel Isoindolone-Based Compounds against Trypanosoma brucei rhodesiense [PDF]

ChemistryOpen, 2021
This study identified the isoindolone ring as a scaffold for novel agents against Trypanosoma brucei rhodesiense and explored the structure‐activity relationships of various aromatic ring substitutions.
Anna Junker, Daniel Gedder Silva, Louis Maes   +2 more
exaly   +8 more sources

C-Terminal Mutants of Apolipoprotein L-I Efficiently Kill Both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense [PDF]

PLoS Pathogens, 2009
Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T.
Laurence Lins, Benoit Vanhollebeke, Etienne Pays   +2 more
exaly   +6 more sources

De Novo Genome Assembly Shows Genome Wide Similarity between Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense [PDF]

PLoS ONE, 2016
BACKGROUND:Trypanosoma brucei is a eukaryotic pathogen which causes African trypanosomiasis. It is notable for its variant surface glycoprotein (VSG) coat, which undergoes antigenic variation enabled by a large suite of VSG pseudogenes, allowing for ...
Oliver Balmer, Serap Aksoy, Joshua B. Benoit   +2 more
exaly   +6 more sources

Transcriptome profiles of Trypanosoma brucei rhodesiense in Malawi reveal focus specific gene expression profiles associated with pathology. [PDF]

PLoS Neglected Tropical Diseases
BackgroundSleeping sickness caused by Trypanosoma brucei rhodesiense is a fatal disease and endemic in Southern and Eastern Africa. There is an urgent need to develop novel diagnostic and control tools to achieve elimination of rhodesiense sleeping ...
Peter Nambala, Harry Noyes, Joyce Namulondo, Oscar Nyangiri, Vincent Pius Alibu, Barbara Nerima, Annette MacLeod, Enock Matovu, Janelisa Musaya, Julius Mulindwa, TrypanoGEN+ Research Group as Members of the H3Africa Consortium   +10 more
doaj   +2 more sources

Reemergence of Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense, Ethiopia [PDF]

Emerging Infectious Diseases
We report 4 cases of human African trypanosomiasis that occurred in Ethiopia in 2022, thirty years after the last previously reported case in the country. Two of 4 patients died before medicine became available.
Adugna Abera, Tihitina Mamecha, Ebise Abose, Belachew Bokicho, Agune Ashole, Tesfahun Bishaw, Abinet Mariyo, Buzayehu Bogale, Haileyesus Terefe, Henok Tadesse, Mahlet Belachew, Hailemariam Difabachew, Araya Eukubay, Solomon Kinde, Abraham Ali, Feyesa Regasa, Fikre Seife, Zeyede Kebede, Mesfin Wossen, Getachew Tollera, Mesay Hailu, Nigus Manaye, Nick Van Reet, Gerardo Priotto, Johan van Griensven, Myrthe Pareyn, Geremew Tasew   +26 more
doaj   +2 more sources

Population genetics of Trypanosoma brucei rhodesiense: clonality and diversity within and between foci. [PDF]

PLoS Neglected Tropical Diseases, 2013
African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development.
Craig W Duffy, Lorna MacLean, Lindsay Sweeney, Anneli Cooper, C Michael R Turner, Andy Tait, Jeremy Sternberg, Liam J Morrison, Annette MacLeod   +8 more
doaj   +2 more sources

Identification of New Anti-Trypanosoma brucei Leads: An Integrated CRK12-Guided Virtual Screen With Experimental Validation. [PDF]

Chem Biol Drug Des
An integrated computational‐experimental workflow enabled CRK12‐guided hit discovery against Trypanosoma brucei under limited structural and ligand data. The workflow of virtual screening and anti‐T. brucei bioassays identified 4 hit compounds, including three low‐micromolar leads (IC50 = 1.47, 0.81, and 1.33 μM). ABSTRACT Human African trypanosomiasis
Li Q, Fu C, Luo J, Zhang Q, Wang L, Liu X, Qiu J, Gong X, Tong HHY, Yao X, Lai D, Liu H.   +11 more
europepmc   +2 more sources

Development of a camelid single-domain antibody-based antigen detection assay for the pan-specific diagnosis of active human and animal Trypanosoma brucei infections [PDF]

Journal of Clinical Microbiology
Trypanosoma brucei infections cause African trypanosomiasis, also known as sleeping sickness in humans and nagana in animals, presenting a significant global health and economic burden, especially in sub-Saharan Africa.
Zeng Li, Bo-kyung Jin, Emily Estefania Timaury Moreno, Andrés Álvarez-Rodríguez, Jo A. Van Ginderachter, Magdalena Radwanska, Yann G. -J. Sterckx, Benoit Stijlemans, Stefan Magez   +8 more
doaj   +2 more sources

African Trypanosomiasis Research at a Crossroads: Bibliometric and Systematic Insights for the Future. [PDF]

J Parasitol Res
Aim Despite a reduction in the overall incidence and prevalence in the last two decades, trypanosomiasis continues to be a public health concern in Africa. This study was designed to comprehensively evaluate current trends in trypanosomiasis research using bibliometric approaches to uncover emerging topics and knowledge gaps, thereby guiding future ...
Ogra IO, Adaji JZ, Jonathan EU, Nwajiani BK, Usman S, Kurovsky A, Sossou K, Balogun EO.   +7 more
europepmc   +2 more sources

Geospatial Analysis of Tsetse Infestation and Animal African Trypanosomiasis in Busia County, Kenya. [PDF]

J Parasitol Res
African trypanosomiasis (AT) is a vector‐borne disease caused by protozoan parasites of the genus Trypanosoma, primarily transmitted through the bite of infected tsetse flies in the genus Glossina. The disease is a major constraint to livestock production, causing reduced productivity, anemia, and mortality in affected animals.
Burudi SS, Mudavadi PO, Cheruiyot JK, Mungube EO.   +3 more
europepmc   +2 more sources