C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. [PDF]
PLoS Pathogens, 2009 Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T.
Laurence Lecordier +7 more
doaj +7 more sources
Decolonising Parasitology: The Case of Trypanosoma brucei rhodesiense
Trends in Parasitology, 2021 Trypanosoma brucei rhodesiense was named after Rhodesia which, in turn, was named after the British imperialist and white supremacist Cecil Rhodes. In the light of the Black Lives Matter movement and contemporary consciousness of postcolonial legacy, it seems opportune to reconsider the subspecies name. Pros and cons of renaming T. b.
Steverding, Dietmar, Tyler, Kevin M.
openaire +6 more sources
De Novo Genome Assembly Shows Genome Wide Similarity between Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. [PDF]
PLoS ONE, 2016 BACKGROUND:Trypanosoma brucei is a eukaryotic pathogen which causes African trypanosomiasis. It is notable for its variant surface glycoprotein (VSG) coat, which undergoes antigenic variation enabled by a large suite of VSG pseudogenes, allowing for ...
Mark Sistrom +5 more
doaj +5 more sources
The origins of a new Trypanosoma brucei rhodesiense sleeping sickness outbreak in eastern Uganda.
Lancet, The, 2001 BACKGROUND: Sleeping sickness, caused by two trypanosome subspecies, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, is a parasitic disease transmitted by the tsetse fly in sub-Saharan Africa.
Coleman, PG +5 more
core +2 more sources
Loop-mediated isothermal amplification (LAMP) method for rapid detection of Trypanosoma brucei rhodesiense [PDF]
PLoS Neglected Tropical Diseases, 2008 Loop-mediated isothermal amplification (LAMP) of DNA is a novel technique that rapidly amplifies target DNA under isothermal conditions. In the present study, a LAMP test was designed from the serum resistance-associated (SRA) gene of Trypanosoma brucei ...
Armstrong, T. +5 more
core +4 more sources
Target product profile: diagnostic test for <i>Trypanosoma brucei rhodesiense</i>. [PDF]
Bull World Health Organ, 2023 Rhodesiense human African trypanosomiasis is a lethal parasitic infection caused by Trypanosoma brucei rhodesiense and transmitted by tsetse flies in eastern and southern Africa. It accounts for around 5% of all cases of human African trypanosomiasis.
Priotto G +14 more
europepmc +3 more sources
Frontiers in Veterinary Science, 2021 While both human and animal trypanosomiasis continue to present as major human and animal public health constraints globally, detailed analyses of trypanosome wildlife reservoir hosts remain sparse.
Keneth Iceland Kasozi +23 more
doaj +1 more source
Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. [PDF]
Cell Mol Life Sci, 2016 Trypanosoma brucei rhodesiense is one of the causative agents of human sleeping sickness, a fatal disease that is transmitted by tsetse flies and restricted to Sub-Saharan Africa. Here we investigate two independent lines of T. b. rhodesiense that have been selected with the drugs melarsoprol and pentamidine over the course of 2 years, until they ...
Graf FE +13 more
europepmc +7 more sources
Suramin action in African trypanosomes involves a RuvB-like DNA helicase
International Journal for Parasitology: Drugs and Drug Resistance, 2023 Suramin is one of the oldest drugs in use today. It is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense, and it is also used for surra in camels caused by Trypanosoma evansi ...
Anna Albisetti +4 more
doaj +1 more source
Recommendations for control of East African sleeping sickness in Uganda
Journal of Global Infectious Diseases, 2010 East African sleeping sickness, caused by Trypanosoma brucei rhodesiense, is prominent in Uganda and poses a serious public health challenge in the region.
Simon Kotlyar
doaj +3 more sources