Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof-of-Concept Study. [PDF]
ChemMedChemNeglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Lowe S +6 more
europepmc +2 more sources
Localization of serum resistance-associated protein in Trypanosoma brucei rhodesiense and transgenic Trypanosoma brucei brucei. [PDF]
Cell Microbiol, 2015 Peer ...
Bart JM +8 more
europepmc +6 more sources
Haemoparasitic Infections in Cattle from a Trypanosoma brucei Rhodesiense Sleeping Sickness Endemic District of Eastern Uganda [PDF]
Tropical Medicine and Infectious Disease, 2020 We carried out a baseline survey of cattle in Kaberamaido district, in the context of controlling the domestic animal reservoir of Trypanosoma brucei rhodesiense human African trypanosomiasis (rHAT) towards elimination.
Enock Matovu +5 more
doaj +2 more sources
The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness. [PDF]
Allergy Asthma Clin Immunol, 2016 Human African trypanosomiasis due to Trypanosoma brucei rhodesiense is invariably fatal if untreated with up to 12.3 million people at a risk of developing the disease in Sub-Saharan Africa. The disease is characterized by a wide spectrum of clinical presentation coupled with differences in disease progression and severity.
Kato CD +4 more
europepmc +4 more sources
Therapeutic Strategies against Leishmania and Trypanosoma
Pathogens, 2023 Human African trypanosomiasis (also known as sleeping sickness, with Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense as etiological agents), American trypanosomiasis (also known as Chagas disease, with Trypanosoma cruzi as the etiological
André L. S. Santos +5 more
doaj +1 more source
Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense [PDF]
Molecules, 2017 Charles O Nnadi +2 more
exaly +2 more sources
Frontiers in Veterinary Science, 2021 While both human and animal trypanosomiasis continue to present as major human and animal public health constraints globally, detailed analyses of trypanosome wildlife reservoir hosts remain sparse.
Keneth Iceland Kasozi +23 more
doaj +1 more source
Recommendations for control of East African sleeping sickness in Uganda
Journal of Global Infectious Diseases, 2010 East African sleeping sickness, caused by Trypanosoma brucei rhodesiense, is prominent in Uganda and poses a serious public health challenge in the region.
Simon Kotlyar
doaj +3 more sources
mBio, 2013 Human African trypanosomiasis is caused by two subspecies of Trypanosoma brucei. Trypanosoma brucei rhodesiense is found in East Africa and frequently causes acute disease, while Trypanosoma brucei gambiense is found in West Africa and is associated with
Ian Goodhead +10 more
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Suramin action in African trypanosomes involves a RuvB-like DNA helicase
International Journal for Parasitology: Drugs and Drug Resistance, 2023 Suramin is one of the oldest drugs in use today. It is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense, and it is also used for surra in camels caused by Trypanosoma evansi ...
Anna Albisetti +4 more
doaj +1 more source