Screening strategies for a sustainable endpoint for Gambiense sleeping sickness [PDF]
, 2020 Background. Gambiense human African trypanosomiasis (gHAT, sleeping sickness) is a vector-borne disease typically fatal without treatment. Intensified, mainly medical-based, interventions in endemic areas have reduced the occurrence of gHAT to ...
Aliee, Maryam +5 more
core +2 more sources
Morphometric diagnosis of Glossina palpalis (Diptera: Glossinidae) population structure in Ghana
BMC Research Notes, 2017 Objective This study aimed to identify isolated population(s) of Glossina palpalis in Ghana using geometric morphometrics to evaluate variations in wing-shape and size between populations of the fly from three regions. Results Wing shape of G.
Faith Ebhodaghe +3 more
doaj +1 more source
mBio, 2021 African trypanosomiasis is a neglected tropical disease caused by the parasitic protozoan Trypanosoma bruceiT.
Anuj Tripathi +7 more
doaj +1 more source
Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis [PDF]
, 2017 Although Trypanosoma brucei spp. was first detected by Aldo Castellani in CSF samples taken from sleeping sickness patients over a century ago there is still a great deal of debate surrounding the timing, route and effects of transmigration of the ...
Bradley, Barbara +2 more
core +1 more source
Human African trypanosomiasis caused by Trypanosoma brucei gambiense: The first case report in China
International Journal of Infectious Diseases, 2019 We report the first imported case in China of human African trypanosomiasis (HAT), caused by Trypanosoma brucei gambiense, in a sailor returning from Gabon in 2014.
Nian Chen +4 more
doaj +1 more source
Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II). [PDF]
, 2005 BACKGROUND: Treatment of late-stage human African trypanosomiasis (HAT) with melarsoprol can be improved by shortening the regimen. A previous trial demonstrated the safety and efficacy of a 10-day treatment schedule.
Asumu, P +10 more
core +2 more sources
Molecular epidemiological studies on animal trypanosomiases in Ghana
Parasites & Vectors, 2012 Background African trypanosomes are extracellular protozoan parasites that are transmitted between mammalian hosts by the bite of an infected tsetse fly. Human African Trypanosomiasis (HAT) or sleeping sickness is caused by Trypanosoma brucei rhodesiense
Nakayima Jesca +5 more
doaj +1 more source
Spatially and genetically distinct African trypanosome virulence variants defined by host interferon-g response [PDF]
, 2007 We describe 2 spatially distinct foci of human African trypansomiasis in eastern Uganda. The Tororo and Soroti foci of <i>Trypanosoma brucei rhodesiense</i> infection were genetically distinct as characterized by 6 microsatellite and 1 ...
Anneli Cooper +19 more
core +1 more source
Frontiers in Tropical DiseasesHuman African trypanosomiasis (HAT), commonly known as sleeping sickness, remains a significant health threat in sub-Saharan Africa. In Nigeria, the challenges of diagnosing and treating HAT are profound, especially in resource-constrained, remote areas.
Kelly Zongo, Rolayo Toyin Emmanuel
doaj +1 more source
Clinical management of East African trypanosomiasis in South Africa: Lessons learned
International Journal of Infectious Diseases, 2018 Background: East African trypanosomiasis is an uncommon, potentially lethal disease if not diagnosed and treated in a timely manner. South Africa, as a centre for emergency medical evacuations from much of sub-Saharan Africa, receives a high proportion ...
John Frean +4 more
doaj +1 more source