Results 51 to 60 of about 28,301 (202)

Exploring 6‐Hydroxy‐3‐Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
New therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
C. N. Pereira, L. da Silva Lara, S. da Costa Lanera, T. Pérez de Souza, M. C. de Souza Pereira, G. L. Delogu, M. Silva dos Santos, M. J. Matos   +7 more
wiley   +1 more source

Challenges facing the elimination of sleeping sickness in west and central Africa: sustainable control of animal trypanosomiasis as an indispensable approach to achieve the goal

Parasites & Vectors, 2015
African trypanosomiases are infectious diseases caused by trypanosomes. African animal trypanosomiasis (AAT) remains an important threat for livestock production in some affected areas whereas human African trypanosomiasis (HAT) is targeted for ...
Gustave Simo, Jean Baptiste Rayaisse
doaj   +1 more source

Availability and affordability of treatment for Human African Trypanosomiasis. [PDF]

, 2001
Human African Trypanosomiasis (HAT) is a re-emerging disease whose usual treatments are becoming less efficient because of the increasing parasite resistance.
Etchegorry, M, Helenport, J, Jannin, J, Legros, D, Pecoul, B   +4 more
core   +3 more sources

Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review

American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 993-1003, May 2026.
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle, Sara M. Sarasua, Tracy Lowe, Christopher L. Farrell, Luigi Boccuto, Charles Schwartz, Anthony E. Pegg, Angela Peron, Victor Faundes, Mythily Ganapathi, Wendy K. Chung, Alban Ziegler, Floris Hofstede, Clément Prouteau, Katharina Steindl, Colleen Olson, Orrin Devinsky, Teresa L. Mastracci, Robert A. Casero Jr., Tracy Murray Stewart, Susan Gilmour, Teri Koerner, Mary Jo Kutler, Surender Rajasekaran, Julianne Michael, André S. Bachmann, Caleb P. Bupp   +26 more
wiley   +1 more source

Molecular identification of different trypanosome species and subspecies in tsetse flies of northern Nigeria [PDF]

, 2016
Background: Animal African Trypanosomiasis (AAT) is caused by several species of trypanosomes including Trypanosoma congolense, T. vivax, T. godfreyi, T. simiae and T. brucei. Two of the subspecies of T. brucei also cause Human African Trypanosomiasis.
Ciosi, Marc, Dede, Peter, Hamilton, Alana, Igbinosa, Igho Benjamin, Isaac, Clement, Masiga, Dan, Nmorsi, Oyebiguwa Patrick Goddey, Scullion, Kathleen Maria, Turner, C. Michael R.   +8 more
core   +1 more source

Occurrence and Public Health Implications of Brucella Abortus and Antimicrobial Residues in Raw Cow Milk in Bukombe District, Tanzania

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Poor husbandry practices in Bukombe District accelerate diseases in livestock and indiscriminate uses of antimicrobials. Cow abortions, raw cow placenta and aborted fetuses feeding dogs, communal grazing and watering and introduction of new animals predict brucellosis in the herd.
Makoye Mhozya, Mwalimu Julius K, Hezron Emmanuel Nonga   +2 more
wiley   +1 more source

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe, Vishal Satikuvar, Tanjia M. Syeda, Monica Cal, Pascal Mäser, Marcel Kaiser, Hachemi Kadri   +6 more
wiley   +1 more source

Phytochemical Diversity, Nutritional Values, and Biological Properties of Halopithys incurva (Hudson) Batters, 1902

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Halopithys incurva is a red macroalga distributed across the Mediterranean Sea and North‐East Atlantic, with occasional reports from the Indian Ocean. It exhibits a rich chemical diversity, including isoflavones, bromophenols, MAAs, pigments, phycobiliproteins, primary metabolites, and neuroactive compounds.
Youssra Aalilou, Abdelhakim Bouyahya, Kaoutar Benrahou, Mustapha Hassoun, Hanaa Moussa, Issam Ameziane El Hassani, Waleed Al Abdulmonem, Learn‐Han Lee, Gokhan Zengin, My El Abbes Faouzi   +9 more
wiley   +1 more source

Prevalence of Human and Animal African Trypanosomiasis in Nigeria: A Scoping Review

Parasitologia
African trypanosomiasis is a protozoan disease that affects both humans and animals. Human African Trypanosomiasis (HAT) is a Neglected Tropical Disease targeted for elimination in 2030.
Chinwe Chukwudi, Elizabeth Odebunmi, Chukwuemeka Ibeachu   +2 more
doaj   +1 more source

Counterflow dielectrophoresis for trypanosome enrichment and detection in blood [PDF]

, 2012
Human African trypanosomiasis or sleeping sickness is a deadly disease endemic in sub-Saharan Africa, caused by single-celled protozoan parasites. Although it has been targeted for elimination by 2020, this will only be realized if diagnosis can be ...
A Carlsson, F Chappuis, FH Labeed, J Vykoukal, JA Rodriguez, KS Ralston, M Jacob, M Murray, MP Barrett, NG Green, P Gascoyne, SC Welburn, SH Holm, U Kim, WH Lumsden, WT Freeman, X-B Wang, XB Wang, Y Huang, ZK Njiru   +19 more
core   +1 more source