Results 71 to 80 of about 16,753 (222)

A mathematical model for evaluating the role of trypanocide treatment of cattle in the epidemiology and control of Trypanosoma brucei rhodesiense and T. b. gambiense sleeping sickness in Uganda

Parasite Epidemiology and Control, 2019
Background: Human and animal African trypanosomiases impose a large economic and health burden in their endemic regions. Large strides have been made in the control of human African trypanosomiasis (HAT), yet these efforts have largely focused on the non-
Julianne Meisner, Ruanne V. Barnabas, Peter M. Rabinowitz   +2 more
doaj   +1 more source

Probing 5‐Nitroimidazole‐Triazole Hybrids as Potential Anti‐Kinetoplastid Agents: Synthesis and In Vitro Efficacy

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira, Gideon D. Badenhorst, Janine Aucamp, Keisuke Suganuma, David D. N’Da   +4 more
wiley   +1 more source

Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors : toward the development of novel therapies for African sleeping sickness [PDF]

, 2010
Trypanosoma brucei, the causative agent of human African trypanosomiasis, affects tens of thousands of sub-Saharan Africans. As current therapeutics are inadequate due to toxic side effects, drug resistance, and limited effectiveness, novel therapies are
Michael A. J. Ferguson, Durrant, Jacob D., Ferguson, Michael A. J., Jacob D. Durrant, Ferguson, Michael A. J.; id_orcid, Michael D. Urbaniak, McCammon, J. Andrew, Urbaniak, Michael D., J. Andrew McCammon   +8 more
core   +1 more source

Natural History of Chronic Kidney Disease in Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 7, Page 1456-1477, July 2026.
ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley   +1 more source

Developing eradication investment cases for onchocerciasis, lymphatic filariasis, and human African trypanosomiasis : rationale and main challenges [PDF]

, 2013
An EIC is essentially an economic composite assessment in the broader meaning of economics, addressing thus all three fundamental economics questions. An EIC in fact answers: 1) the ‘‘What’’ question, that compares remaining in control mode versus moving
Steinmann, Peter, Marcel Tanner, Peter Steinmann, de Savigny, Don, Tediosi, Fabrizio, Fabrizio Tediosi, Don de Savigny, María Gloria Basáñez, Tanner, Marcel   +8 more
core   +1 more source

Influence de la trypanosomose sur la reproduction des bovins en Afrique [PDF]

Tropicultura, 2000
The Influence of African Animal Trypanosomiasis on Reproduction of Cattle in Africa. The main effects of African animal Trypanosomiasis on reproduction of cattle have been reviewed.
Zecchini, M., Kageruka, P., De Deken, R.
doaj  

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman, Janine Aucamp, Helena D. Janse van Rensburg, Christina Kannigadu, Rotondwa Mphephu, Andrew J. Swarts, Keisuke Suganuma, David D. N'Da   +7 more
wiley   +1 more source

Estimates of the duration of the early and late stage of gambiense sleeping sickness [PDF]

, 2008
Background: The durations of untreated stage 1 (early stage, haemo-lymphatic) and stage 2 (late stage, meningo-encephalitic) human African trypanosomiasis (sleeping sickness) due to Trypanosoma brucei gambiense are poorly quantified, but key to ...
Filipe, João AN, Haydon Daniel T, Filipe João AN, Chappuis, F., Checchi Francesco, Haydon, D.T., Checchi, F, Checchi, Francesco, Chandramohan, D, Chappuis, F, Chandramohan, Daniel, Filipe, J A N, Filipe, João A N., Haydon, Daniel T, Haydon, D T, Filipe, J.A., Haydon, Daniel T., Checchi, F., Chandramohan, D., Chappuis, François, Chappuis François, Chandramohan Daniel   +21 more
core   +2 more sources

Geographical Variation in the Gut Microbiota of Duttaphrynus melanostictus: Relative Contributions of Environmental Filtering and Host Physiological Modulation

Ecology and Evolution, Volume 16, Issue 7, July 2026.
We examined gut microbial communities in 385 Asian common toads (Duttaphrynus melanostictus) from 14 populations across southern China, using 16S rRNA sequencing to assess the roles of climate, topography, and host traits in shaping community structure.
Di K. Zhu, Nan Wen, Ke Y. Peng, Lin L. Jiang, Jin Li, Li Zhao   +5 more
wiley   +1 more source

Interplay Between Infectious Diseases and the Endocrine System: An Overview and Clinical Insights

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
Infectious diseases can disrupt endocrine homeostasis through direct cytopathic injury, autoimmune dysregulation, or pathogen‐derived hormone‐like effects. Viruses and bacteria are the most frequent agents, whereas fungi and parasites contribute less commonly, even remaining clinically relevant, especially in the immunocompromised population.
Francesco Capoccia, Valentina D'Onghia, Valentina Semeraro, Esposito Susanna, Maria Elisabeth Street   +4 more
wiley   +1 more source