Results 81 to 90 of about 1,412,769 (167)

A murine model of Trypanosoma brucei-induced myocarditis and cardiac dysfunction

Microbiology Spectrum
Trypanosoma brucei is a protozoan parasite that causes human and animal African trypanosomiases (HAT and AAT). Cardiac symptoms are commonly reported in HAT patients, and intracardiac parasites with accompanying myocarditis have been observed in both ...
Nathan P. Crilly, Marcelle Dina Zita, Alexander K. Beaver, Polina Sysa-Shah, Aashik Bhalodia, Kathy Gabrielson, Luigi Adamo, Monica R. Mugnier   +7 more
doaj   +1 more source

Probing 5‐Nitroimidazole‐Triazole Hybrids as Potential Anti‐Kinetoplastid Agents: Synthesis and In Vitro Efficacy

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira, Gideon D. Badenhorst, Janine Aucamp, Keisuke Suganuma, David D. N’Da   +4 more
wiley   +1 more source

Pharmacological Approaches to Antitrypanosomal Chemotherapy

Memorias do Instituto Oswaldo Cruz, 1999
There is an urgent need for new drugs for the chemotherapy of human African trypanosomiasis, Chagas disease and leishmaniasis. Progress has been made in the identification and characterization of novel drug targets for rational chemotherapy and ...
Simon L Croft
doaj   +1 more source

Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis

Tropical Medicine and Infectious Disease, 2020
Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs.
Srinivasa P S Rao, Suresh B Lakshminarayana, Jan Jiricek, Marcel Kaiser, Ryan Ritchie, Elmarie Myburgh, Frantisek Supek, Tove Tuntland, Advait Nagle, Valentina Molteni, Pascal Mäser, Jeremy C Mottram, Michael P Barrett, Thierry T Diagana   +13 more
doaj   +1 more source

First PATTEC consultative workshop on strategies, technical advances and partnerships in tsetse and trypanosomosis management

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2015
Tsetse and trypanosomiasis (T&T) remain endemic in many countries, although many efforts have been made in recent decades within the framework of the Pan-African Tsetse and Trypanosomiasis Eradication Campaign (PATTEC) Initiative, and despite progress ...
Hassane H. Mahamat
doaj   +1 more source

Efficacy, safety, and dose of Pafuramidine, a new oral drug for treatment of first stage sleeping sickness, in a phase 2a clinical study and phase 2b randomized clinical studies [PDF]

, 2016
Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death.
Carol A. Olson (1807531), Patrick D Yeramian, Bilenge, Constantin Miaka Mia, Pascal Lutumba, Manuel, F, Sonja C Bernhard, Allen, James L., Mpanya, Alain, Alain Mpanya, Blum, Johannes, Lubaki, J P, Richard R Tidwell, Gabriele Pohlig, Constantin Miaka Mia Bilenge, Yeramian, Patrick D., Kazadi Kyanza Serge, Tidwell, R R, Thompson, Mark, Alfred Mpoo Mpoto, Bernhard, Sonja C., Tidwell, Richard R., Christian Burri (141244), Carol A Olson, Sonja C. Bernhard (1807537), Blaise Fungula Munungu, Bernhard, S C, James L Allen, Burri, Christian, Munungu, Blaise Fungula, Olson, Carol A., Francisco Manuel (1807528), Victor Kande Betu Ku Mesu, Constantin Miaka Mia Bilenge (1807513), Lutumba, P, Pohlig, G, Mark Thompson, Francisco Manuel, Blaise Fungula Munungu (1807519), Merolle, Ada, Lutumba, Pascal, Ada Merolle, Mpoto, Alfred Mpoo, Mesu, V K, Christian Burri, Jean-Pierre Fina Lubaki (1807546), Allen, J L, Josenando, Théophilo, Ada Merolle (1807540), Johannes Blum, Josenando, T, Lubaki, Jean-Pierre Fina, Gabriele Pohlig (267149), Pohlig, Gabriele, Bilenge, C M, Blum, J, Manuel, Francisco, Merolle, A, Mesu, Victor Kande Betu Ku, Yeramian, P D, Alfred Mpoo Mpoto (1807534), Serge, K K, Munungu, B F, Alain Mpanya (267142), Mark Thompson (533940), James L. Allen (1807522), Olson, C A, Johannes Blum (141240), Mpoto, A M, Victor Kande Betu Ku Mesu (1807510), Théophilo Josenando (1807516), Mpanya, A, Thompson, M, Patrick D. Yeramian (1807543), Richard R. Tidwell (148409), Théophilo Josenando, Burri, C, Jean-Pierre Fina Lubaki, Serge, Kazadi Kyanza, Kazadi Kyanza Serge (1807525), Pascal Lutumba (116142), Burri C, Mpoto AM, Mpanya A, Tidwell RR, Bilenge CM, Manuel F, Bernhard SC, Lubaki JP, Mesu VK, Allen JL, Pohlig G, Merolle A, Josenando T, Lutumba P, Serge KK, Munungu BF, Olson CA, Blum J, Yeramian PD, Thompson M   +99 more
core   +2 more sources

The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic Human African Trypanosomiasis [PDF]

, 2010
<p><b>Background:</b> <i>Trypanosoma brucei gambiense</i> is the causative agent of chronic Human African Trypanosomiasis or sleeping sickness, a disease endemic across often poor and rural areas of Western and Central ...
Martin A Aslett, Hertz-Fowler Christiane, Chukualim, B., Gibson, W., Melville, S.E., Jackson Andrew P., Jackson, A.P., Jackson, A., Capewell, P., Sanders Mandy, Annette MacLeod, McQuillan, J, Quail, M.A., MacLeod Annette, Melville Sara E., Melville, S., McQuillan, J., Paul Capewell, Aslett Martin A., Bridget Chukualim, MacLeod, A., Aslett, M., Hertz-Fowler, C., McQuillan Jacqueline, Aslett, M.A., Mandy Sanders, Berry Andrew, Michael A Quail, Barry, J.D., Berriman, M., Sanders, M., Wendy Gibson, Sara E Melville, Jacqueline McQuillan, Gibson, WC, Quail Michael A., Berry, A., J David Barry, Andrew P Jackson, Andrew Berry, Christiane Hertz-Fowler, Matthew Berriman, Chukualim Bridget, Gibson Wendy, Barry J. David, Capewell Paul, Berriman Matthew   +46 more
core   +1 more source

Effect of Tetracycline on Late-stage African trypanosomiasis in Rats [PDF]

, 2016
The effect of tetracycline on late stage African trypanosomiasis was examined in an in vivo experiment using rats infected with Trypanosoma brucei brucei.
Ekanem, J.T., Johnson, T.O.
core   +1 more source

The household burden of sleeping sickness: out-of-pocket costs for diagnosis and treatment

BMJ Global Health
Purpose This study estimated out-of-pocket (OOP) expenses associated with Human African Trypanosomiasis (HAT) care in the Democratic Republic of the Congo (DRC) and explored how they influenced care-seeking behaviour and participation in HAT control ...
Fabrizio Tediosi, Alain Mpanya, Epco Hasker, Erick Miaka, Rian Snijders, Marina Antillon, Alain Fukinsia, Pathou Nganzobo   +7 more
doaj   +1 more source

Bayesian geostatistical analysis and prediction of Rhodesian human African trypanosomiasis [PDF]

, 2010
BackgroundThe persistent spread of Rhodesian human African trypanosomiasis (HAT) in Uganda in recent years has increased concerns of a potential overlap with the Gambian form of the disease.
Fevre, Eric M., Welburn Susan C., Peter M Atkinson, Kakembo, A.S., Peter W Gething, Kakembo, Abbas S. L., Susan C Welburn, Wardrop, Nicola A., Peter W. Gething, Picozzi, K., Atkinson Peter M., Nicola A. Wardrop, Gething, Peter W., Peter M. Atkinson, Susan C. Welburn, Fèvre Eric M., Picozzi, Kim, Kakembo, Abbas S.L., Wardrop, N.A., Eric M. Fèvre, Gething, P.W., Eric M Fèvre, Wardrop Nicola A., Kakembo Abbas S. L., Abbas S L Kakembo, Nicola A Wardrop, Kim Picozzi, Picozzi Kim, Atkinson, Peter M., Welburn, Susan C., Atkinson, P.M., Abbas S. L. Kakembo, Gething Peter W.   +32 more
core   +1 more source