Results 91 to 100 of about 28,301 (202)

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

Pharmacological Approaches to Antitrypanosomal Chemotherapy

Memorias do Instituto Oswaldo Cruz, 1999
There is an urgent need for new drugs for the chemotherapy of human African trypanosomiasis, Chagas disease and leishmaniasis. Progress has been made in the identification and characterization of novel drug targets for rational chemotherapy and ...
Simon L Croft
doaj   +1 more source

Through the dark continent: African trypanosome development in the tsetse fly [PDF]

, 2013
African trypanosomes are unicellular flagellated parasites causing trypanosomiases in Africa, a group of severe diseases also known as sleeping sickness in human and nagana in cattle.
Rotureau, Brice, Van Den Abbeele, Jan
core   +4 more sources

Characterization of Trypanosoma brucei gambiense variant surface glycoprotein LiTat 1.5 [PDF]

, 2012
At present, all available diagnostic antibody detection tests for Trypanosoma brucei gambiense human African trypanosomiasis are based on predominant variant surface glycoproteins (VSGs), such as VSG LiTat 1.5. During investigations aiming at replacement
Büscher, P., Guisez, Y., Lejon, V., Rogé, S., Van Nieuwenhove, L.   +4 more
core   +1 more source

A systematic review and meta-analysis of trypanosome prevalence in tsetse flies [PDF]

, 2017
Background: The optimisation of trypanosomosis control programs warrants a good knowledge of the main vector of animal and human trypanosomes in sub-Saharan Africa, the tsetse fly.
Abdi, Reta D, Agga, Getahun E, Aregawi, Weldegebrial G, Bekana, Merga, Delespaux, Vincent, Duchateau, Luc, Van Leeuwen, Thomas   +6 more
core   +2 more sources

Iloprost treatment enhanced IL-4 signalling to reverse trypanosome-induced cognitive deficits and suppressed neuroinflammation in mice

International Journal of Infectious Diseases
Introduction: The development of neurological disorders following trypanosome brain infection has been recognised for over a century. However, an ongoing endeavour persists to comprehensively understand the neurocognitive and neuropathological changes ...
Dr Oluwashola Olaolu, Professor Hajierah Davids, Professor Gill. B Dealtry, Miss Oluwatoyin Morenikeji, Dr Emmanuel T Obishakin, Mrs Binta Iliayasu, Dr Azeez Idris, Dr Chris Duyilemi Ajonijebu   +7 more
doaj   +1 more source

Chemotherapy of Human African Trypanosomiasis

Interdisciplinary Perspectives on Infectious Diseases, 2009
Human Africa trypanosomiasis is a centuries-old disease which has disrupted sub-Saharan Africa in both physical suffering and economic loss. This article presents an update of classic chemotherapeutic agents, in use for >50 years and the recent ...
Cyrus J. Bacchi
doaj   +1 more source

Nanobodies as tools to understand, diagnose, and treat African trypanosomiasis [PDF]

, 2017
African trypanosomes are strictly extracellular protozoan parasites that cause diseases in humans and livestock and significantly affect the economic development of sub-Saharan Africa.
Caljon, Guy, De Baetselier, Patrick, Magez, Stefan, Stijlemans, Benoit, Van Den Abbeele, Jan, Van Ginderachter, Jo A   +5 more
core   +1 more source

Risk for Human African Trypanosomiasis, Central Africa, 2000–2009

Emerging Infectious Diseases, 2011
Comprehensive georeference records for human African trypanosomiasis in Cameroon, Central African Republic, Chad, Congo, Equatorial Guinea, and Gabon were combined with human population layers to estimate a kernel-smoothed relative risk function.
Pere P. Simarro, Giuliano Cecchi, José R. Franco, Massimo Paone, Eric M. Fèvre, Abdoulaye Diarra, José Antonio Ruiz Postigo, Raffaele C. Mattioli, Jean G. Jannin   +8 more
doaj   +1 more source

African Trypanosomiasis [PDF]

, 2020
Sanjeev Krishna, Christian Kleine, August Stich   +2 more
  +6 more sources