Results 81 to 90 of about 7,822 (201)

Beyond immune escape:a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei [PDF]

, 2017
Suramin is one of the first drugs developed in a medicinal chemistry program (Bayer, 1916), and it is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense.
Cal, Monica, Graf, Fabrice E., Kunz Renggli, Christina, Mäser, Pascal, Ndomba, Emiliana, Schmidt, Remo S., Wenzler, Tanja, Wiedemar, Natalie, Zwyer, Michaela   +8 more
core   +3 more sources

Spiroplasma infection in colonized Glossina fuscipes fuscipes: impact on mass rearing and the sterile insect technique

Insect Science, Volume 32, Issue 5, Page 1761-1776, October 2025.
Abstract Tsetse flies (Glossina spp.) can vector the parasites (Trypanosoma spp.) that cause the socioeconomically devastating neglected tropical diseases human and animal African trypanosomoses. In addition to this parasite, tsetse can harbor four genera of endosymbiotic bacteria, including Wigglesworthia, Sodalis, Wolbachia, and Spiroplasma, which ...
Kiswend‐sida M. Dera, Daouda Tande Barro, Bénéwendé Aristide Kaboré, Fabian Gstöttenmayer, Mouhamadou M. Dieng, Soumaïla Pagabeleguem, Brian L. Weiss, Giulia Fiorenza, Riccardo Piccinno, Anna R. Malacrida, Serap Aksoy, Chantel J. de Beer, Robert L. Mach, Marc J. B. Vreysen, Adly M. M. Abd‐Alla   +14 more
wiley   +1 more source

Comparative analysis of cerebrospinal fluid from the meningo-encephalitic stage of T. b. gambiense and rhodesiense sleeping sickness patients using TMT quantitative proteomics

Data in Brief, 2015
The quantitative proteomics data here reported are part of a research article entitled “Increased acute immune response during the meningo-encephalitic stage of Trypanosoma brucei rhodesiense sleeping sickness compared to Trypanosoma brucei gambiense ...
Natalia Tiberti, Jean-Charles Sanchez
doaj   +1 more source

Improvement of colony management in insect mass‐rearing for sterile insect technique applications

Insect Science, Volume 32, Issue 5, Page 1476-1494, October 2025.
Abstract Sterile Insect Technique (SIT) applications against major insect pests and disease vectors rely on the cost‐effective production of high‐quality sterile males. This largely depends on the optimal management of target pest colonies by maximizing the benefits provided by a genetically rich and pathogen‐free mother colony, the presence of ...
Adly M.M. Abd‐Alla, Anne Geiger, David Haymer, Salvador Herrero, Johannes, A. Jehle, Fathiya Khamis, Pablo Liedo, Anna R. Malacrida, Flobert Njiokou, Thiago Mastrangelo, Soumaïla Pagabeleguem, Edwin M. Ramırez‐Santos, Vera I.D. Ros, Diego F. Segura, George Tsiamis, Brian L. Weiss   +16 more
wiley   +1 more source

Search for the wild animal reservoir of Trypanosoma sp in mammals of N’Djili-Brasseries (Kinshasa, Democratic Republic of Congo)

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2018
During 6 months, 201 specimens of wild mammals representing 7 species divided into 6 genera, 4 families and 3 orders, of which 2 Genetta angolensis, 3 Nandinia binotata, 10 Galagoides demidoff, 35 Protoxerus strangeri, 73 Funisciurus congicus, 15 Rattus ...
M.W. Kabamba Mwamba, G. Tshilenge, J. Malekani   +2 more
doaj  

Phase II evaluation of sensitivity and specificity of PCR and NASBA followed by oligochromatography for diagnosis of human African trypanosomiasis in clinical samples from D.R. Congo and Uganda. [PDF]

PLoS Neglected Tropical Diseases, 2010
BACKGROUND: The polymerase chain reaction (PCR) and nucleic acid sequence-based amplification (NASBA) have been recently modified by coupling to oligochromatography (OC) for easy and fast visualisation of products.
Enock Matovu, Claire M Mugasa, Rosine Ali Ekangu, Stijn Deborggraeve, George W Lubega, Thierry Laurent, Gerard J Schoone, Henk D Schallig, Philippe Büscher   +8 more
doaj   +1 more source

New tsetse (Glossina fuscipes fuscipes) genomes generated from wild and laboratory‐reared specimens

Insect Science, Volume 32, Issue 5, Page 1588-1596, October 2025.
Abstract Tsetse (Glossina spp.) are vectors of African trypanosomes that cause devastating human and animal African trypanosomiases. While much of the research to better understand tsetse genetics and physiology relies on colony‐reared flies, these flies may not represent the genetic diversity found in natural wild populations due to their long‐term ...
Daniel J. Bruzzese, Brian L. Weiss, Richard Echodu, Paul O. Mireji, Adly M.M Abd‐Alla, Serap Aksoy   +5 more
wiley   +1 more source

In Vitro Leishmanicidal Efficacy of Synthesized Arylidene Analogues of Glitazone

Drug Development Research, Volume 86, Issue 5, August 2025.
ABSTRACT Diabetes is a fast‐growing health issue in low‐ and middle‐income countries, with ~80% of diabetics living in the tropics and sub‐tropics. It is a deadly condition claiming the lives of millions of individuals annually, with no therapeutic treatment available to date. The management of diabetes is thus limited to symptomatic relief by glycemic
Janine Aucamp, Helena D. Janse van Rensburg, Simon S. Mnyakeni‐Moleele, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source

Human African Trypanosomiasis in Emigrant Returning to China from Gabon, 2017

Emerging Infectious Diseases, 2018
Human African trypanosomiasis is endemic to parts of sub-Saharan Africa and should be considered in the differential diagnosis of patients who have visited or lived in Africa.
Xinyu Wang, Qiaoling Ruan, Wen-Hong Zhang, Jianfei Gu, Yiyi Qian, Muxin Chen, Qin Liu, Qing Lu, Wenhong Zhang   +8 more
doaj   +1 more source

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer, Agbe, Bruhn, Brun, Cristodero, Dean, Deterding, Herbert, Hoare, Holmes, Kaminsky, Lai, Lanteri, M. K. Gould, Mathis, Mukherjee, Painter, Priest, Roy Chowdhury, Räz, Schnaufer, Schnaufer, Schnaufer, Shapiro, Stuart, Tang, Thuita, Ward, Wenzler, Wenzler, Wilson, Zhang, Zuma   +32 more
core   +1 more source