Results 51 to 60 of about 53,099 (190)

In-hospital safety in field conditions of Nifurtimox Eflornithine Combination Therapy (NECT) for T. B. Gambiense Sleeping Sickness [PDF]

, 2012
Trypanosoma brucei (T.b.) gambiense Human African trypanosomiasis (HAT; sleeping sickness) is a fatal disease. Until 2009, available treatments for 2(nd) stage HAT were complicated to use, expensive (eflornithine monotherapy), or toxic, and ...
Kisala, M, Schmid, C., Kisala, M., Mordt, O. V., Ismael Lumpungu, Mutanda, S, Mays Kisala, Kande, V, Nganzobo Pathou, Kuemmerle Andrea, Blum Johannes, Medard Ilunga, Nono Mubwa, Lumpungu Ismael, Mubwa Nono, Mordt Olaf Valverde, Schmid Caecilia, Mubwa, N, Blesson Severine, Wilfried Mutombo, Nganzobo, P., Mutombo Wilfried, Victor Kande, Mordt, O V, Tete Digas, Tete, D, Blesson, S, Kümmerle, A., Ilunga Medard, Schmid, C, Ilunga, M., Kuemmerle, A, Sylvain Mutanda, Ghabri, S, Ghabri, S., Andrea Kuemmerle, Lumpungu, I, Salah Ghabri, Kande, V., Johannes Blum, Lumpungu, I., Ghabri Salah, Blum, J, Digas Tete, Mubwa, N., Mutanda, S., Pathou Nganzobo, Ilunga, M, Caecilia Schmid, Tete, D., Nganzobo, P, Blum, J., Mutombo, W., Mutanda Sylvain, Kisala Mays, Blésson, S., Olaf Valverde Mordt, Severine Blesson, Kande Victor, Mutombo, W   +59 more
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Measure of Molecular Diversity within the Trypanosoma brucei Subspecies Trypanosoma brucei brucei and Trypanosoma brucei gambiense as Revealed by Genotypic Characterization

Experimental Parasitology, 2001
We have evaluated whether sequence polymorphisms in the rRNA intergenic spacer region can be used to study the relatedness of two subspecies of Trypanosoma brucei. Thirteen T. brucei isolates made up of 6 T. b. brucei and 7 T. b. gambiense were analyzed using restriction fragment length polymorphism (RFLP).
Agbo, E.C., Majiwa, P.A.O., Classsen, E.J.H.M., Roos, M.H.   +3 more
openaire   +3 more sources

Enzyme polymorphism and the identity of Trypanosoma brucei gambiense

Parasitology, 1987
SUMMARYThirty-two isolates from man in known areas of Gambian trypanosomiasis, in the Sudan, Kenya, Zaire, Nigeria, Ivory Coast, Burkina Faso, Liberia and Senegal, were examined by isoenzyme electrophoresis of 11 enzymes. Comparisons were also made with our previously published results on 23 other stocks of similar origins, which had been examined in ...
D G, Godfrey, C M, Scott, W C, Gibson, D, Mehlitz, U, Zillmann   +4 more
openaire   +2 more sources

The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction. [PDF]

, 2004
Throughout its elongation, the new flagellum of the procyclic form of the African trypanosome Trypanosoma brucei is tethered at its tip to the lateral aspect of the old flagellum.
Vaughan, Sue, Baines, Andrea, Moreira-Leite, Flavia, Briggs, Laura, Gull, Keith, McKean, Paul G., Davidge, Jacqueline   +6 more
core   +5 more sources

Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human african trypanosomiasis [PDF]

, 2014
The diagnosis of human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). There is no immunodiagnostic for HAT caused by T. b. rhodesiense.
Sastry Lalitha, Lalitha Sastry, Lauren Sullivan, Sullivan Lauren, Ferguson, Michael A J; id_orcid, Fleming Jennifer, Steven J Wall, Sullivan, Lauren, Fleming, Jennifer, Angela Mehlert, Michael A J Ferguson, Mehlert Angela, Sastry, Lalitha, Wall, Steven J., Jennifer Fleming, Ferguson Michael A. J., Ferguson, Michael A. J., Wall, Steven J, Wall Steven J., Fleming, Jennifer R., Mehlert, Angela   +20 more
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Population genetics of trypanosoma brucei rhodesiense: clonality and diversity within and between foci [PDF]

, 2013
African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development.
C. Michael R. Turner, Cooper, Anneli, Duffy, Craig W, Duffy, C.W., C Michael R Turner, Annette MacLeod, Cooper Anneli, MacLeod Annette, Lorna MacLean (126077), Lindsay Sweeney, MacLeod, A., MacLeod, Annette, Craig W. Duffy, Morrison, Liam; id_orcid, Tait, Andy, Morrison, L.J., Craig W Duffy, Sternberg, Jeremy, Sweeney, Lindsay, Morrison Liam J., Cooper, A., Sternberg, J., Tait, A., Duffy, Craig W., Jeremy Sternberg, Andy Tait, Lindsay Sweeney (51760), MacLean Lorna, Tait Andy, Duffy, Craig, Liam J Morrison, Tait, Andrew, Liam J. Morrison, Andy Tait (12786), Turner, C.M.R., Sweeney Lindsay, Liam J. Morrison (211421), Duffy Craig W., C. Michael R. Turner (12785), Turner, C M, MacLean, L., Craig W. Duffy (429693), Anneli Cooper (51759), Anneli Cooper, Turner, C Michael R, Morrison, Liam J, Jeremy Sternberg (485210), Sweeney, L., Annette MacLeod (12779), Sternberg Jeremy, Lorna MacLean, Turner C. Michael R., MacLean, Lorna, Morrison, Liam J., Turner, C. Michael R.   +54 more
core   +1 more source

Estimates of the duration of the early and late stage of gambiense sleeping sickness [PDF]

, 2008
Background: The durations of untreated stage 1 (early stage, haemo-lymphatic) and stage 2 (late stage, meningo-encephalitic) human African trypanosomiasis (sleeping sickness) due to Trypanosoma brucei gambiense are poorly quantified, but key to ...
Filipe, João AN, Haydon Daniel T, Filipe João AN, Chappuis, F., Checchi Francesco, Haydon, D.T., Checchi, F, Checchi, Francesco, Chandramohan, D, Chappuis, F, Chandramohan, Daniel, Filipe, J A N, Filipe, João A N., Haydon, Daniel T, Haydon, D T, Filipe, J.A., Haydon, Daniel T., Checchi, F., Chandramohan, D., Chappuis, François, Chappuis François, Chandramohan Daniel   +21 more
core   +3 more sources

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several anti-trypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
Schnaufer, Achim; id_orcid, Gould, Matthew K   +1 more
core   +1 more source

Untreated Human Infections by Trypanosoma brucei gambiense Are Not 100% Fatal

PLoS Neglected Tropical Diseases, 2012
El resultado final de la infección por Trypanosoma brucei gambiense, el principal agente de la enfermedad del sueño, siempre se ha considerado invariablemente fatal. Si bien los informes escasos y antiguos han mencionado casos de autocuración en pacientes no tratados, estos estudios sufrieron la falta de herramientas de diagnóstico precisas disponibles
Vincent Jamonneau, Hamidou Ilboudo, Jacques Kaboré, Dramane Kaba, Mathurin Koffi, Philippe Solano, André Garcia, David Courtin, Claude Laveissière, Lingué Kouakou, Philippe Büscher, Bruno Bucheton   +11 more
openaire   +5 more sources

Accuracy of five algorithms to diagnose gambiense human African trypanosomiasis. [PDF]

, 2011
Algorithms to diagnose gambiense human African trypanosomiasis (HAT, sleeping sickness) are often complex due to the unsatisfactory sensitivity and/or specificity of available tests, and typically include a screening (serological), confirmation ...
Francesco Checchi, Gerardo Priotto, Daniel Chandramohan, Checchi Francesco, Unni Karunakara, Priotto Gerardo, Checchi, F, Priotto, Gerardo, Priotto, G, Checchi, Francesco, Chappuis, F, Chandramohan, D, Chandramohan, Daniel, Karunakara Unni, François Chappuis, Karunakara, U, Karunakara, Unni, Chappuis, François, Chappuis François, Chandramohan Daniel   +19 more
core   +2 more sources