Luminescent multiplex viability assay for Trypanosoma brucei gambiense [PDF]
Parasites & Vectors, 2013 New compounds for the treatment of human African trypanosomiasis (HAT) are urgently required. Trypanosoma brucei (T.b.) gambiense is the leading cause of HAT, yet T.b. gambiense is often not the prime target organism in drug discovery. This may be attributed to the difficulties in handling this subspecies and the lack of an efficient viability assay to
Van Reet, Nick +4 more
openaire +2 more sources
Association between IL1 gene polymorphism and human African trypanosomiasis in populations of sleeping sickness foci of southern Cameroon. [PDF]
PLoS Neglected Tropical Diseases, 2019 BACKGROUND:Human African Trypanosomiasis (HAT) is a neglected tropical disease caused by infections due to Trypanosoma brucei subspecies. In addition to the well-established environmental and behavioural risks of becoming infected, there is evidence for ...
Elvis Ofon +10 more
doaj +1 more source
Wild chimpanzees are infected by Trypanosoma brucei
International Journal for Parasitology: Parasites and Wildlife, 2015 Although wild chimpanzees and other African great apes live in regions endemic for African sleeping sickness, very little is known about their trypanosome infections, mainly due to major difficulties in obtaining their blood samples.
Milan Jirků +13 more
doaj +1 more source
In silico analysis of the HSP90 chaperone system from the African trypanosome, Trypanosoma brucei
Frontiers in Molecular Biosciences, 2022 African trypanosomiasis is a neglected tropical disease caused by Trypanosoma brucei (T. brucei) and spread by the tsetse fly in sub-Saharan Africa. The trypanosome relies on heat shock proteins for survival in the insect vector and mammalian host.
Miebaka Jamabo +5 more
doaj +1 more source
Molecular epidemiology of African sleeping sickness [PDF]
, 2009 Human sleeping sickness in Africa, caused by Trypanosoma brucei spp. raises a number of questions. Despite the widespread distribution of the tsetse vectors and animal trypanosomiasis, human disease is only found in discrete foci which periodically give ...
A. TAIT +5 more
core +2 more sources
International Journal for Parasitology: Drugs and Drug Resistance, 2015 Aquaglyceroporin-2 is a known determinant of melarsoprol–pentamidine cross-resistance in Trypanosoma brucei brucei laboratory strains. Recently, chimerization at the AQP2–AQP3 tandem locus was described from melarsoprol–pentamidine cross-resistant ...
Fabrice E. Graf +5 more
doaj +1 more source
Human African trypanosomiasis [PDF]
, 2009 Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies.
Abel +143 more
core +2 more sources
Molecular variation of Trypanosoma brucei subspecies as revealed by AFLP fingerprinting [PDF]
, 2002 Genetic analysis of Trypanosoma spp. depends on the detection of variation between strains. We have used the amplified fragment length polymorphism (AFLP) technique to develop a convenient and reliable method for genetic characterization of Trypanosome ...
Agbo, E.E.C. +3 more
core +4 more sources
Characterization of recombinant Trypanosoma brucei gambiense Translationally Controlled Tumor Protein (rTbgTCTP) and its interaction with Glossina midgut bacteria [PDF]
Gut Microbes, 2017 Geraldine Bossard +2 more
exaly +2 more sources
Human and animal Trypanosomes in Côte d'Ivoire form a single breeding population.
PLoS ONE, 2013 BackgroundTrypanosoma brucei is the causative agent of African Sleeping Sickness in humans and contributes to the related veterinary disease, Nagana. T. brucei is segregated into three subspecies based on host specificity, geography and pathology. T.
Paul Capewell +7 more
doaj +1 more source