The Genome Sequence of Trypanosoma brucei gambiense, Causative Agent of Chronic Human African Trypanosomiasis [PDF]
PLoS Neglected Tropical Diseases, 2010 BackgroundTrypanosoma brucei gambiense is the causative agent of chronic Human African Trypanosomiasis or sleeping sickness, a disease endemic across often poor and rural areas of Western and Central Africa.
Andrew Paul Jackson +2 more
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Differences between Trypanosoma brucei gambiense Groups 1 and 2 in Their Resistance to Killing by Trypanolytic Factor 1 [PDF]
PLoS Neglected Tropical Diseases, 2011 BackgroundThe three sub-species of Trypanosoma brucei are important pathogens of sub-Saharan Africa. T. b. brucei is unable to infect humans due to sensitivity to trypanosome lytic factors (TLF) 1 and 2 found in human serum. T. b. rhodesiense and T.
Annette Macleod +2 more
exaly +3 more sources
Evidence of the absence of human African trypanosomiasis in two northern districts of Uganda: Analyses of cattle, pigs and tsetse flies for the presence of Trypanosoma brucei gambiense [PDF]
PLoS Neglected Tropical Diseases, 2020 BACKGROUND:Large-scale control of sleeping sickness has led to a decline in the number of cases of Gambian human African trypanosomiasis (g-HAT) to
Stephen Torr +2 more
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Neural Damage in Experimental Trypanosoma brucei gambiense Infection: The Suprachiasmatic Nucleus [PDF]
Frontiers in Neuroanatomy, 2018 Trypanosoma brucei (T. b.) gambiense is the parasite subspecies responsible for most reported cases of human African trypanosomiasis (HAT) or sleeping sickness.
Chiara Tesoriero +4 more
doaj +5 more sources
Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria [PDF]
Parasites & Vectors, 2019 Background Animal trypanosomosis is endemic in Nigeria, while the human disease caused by Trypanosoma brucei gambiense is rarely reported nowadays after efforts to bring it under control in the 20th century.
Paschal Ugochukwu Umeakuana +3 more
doaj +5 more sources
The TgsGP Gene Is Essential for Resistance to Human Serum in Trypanosoma brucei gambiense [PDF]
PLoS Pathogens, 2013 Trypanosoma brucei gambiense causes 97% of all cases of African sleeping sickness, a fatal disease of sub-Saharan Africa. Most species of trypanosome, such as T. b.
Caroline Clucas +2 more
exaly +6 more sources
Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense [PDF]
Nature Communications, 2022 Decreased functionality and expression of trypanosome haptoglobin-hemoglobin receptor (HpHbR) is one of the evolutionary modifications that have allowed Trypanosoma brucei gambiense to infect humans. Here, Horakova et al.
Eva Horáková +8 more
doaj +2 more sources
Target product profile: diagnostic test for Trypanosoma brucei gambiense [PDF]
Bulletin of the World Health Organization, 2023 Human African trypanosomiasis is a life-threatening parasitic infection endemic to sub-Saharan Africa. Around 95% of cases are due to Trypanosoma brucei gambiense, found in western and central Africa. Clinical signs and symptoms are nonspecific, current diagnostic tests are not sufficiently accurate, and parasitological confirmation of infection ...
Priotto, G. +14 more
openaire +3 more sources
Two-Year Follow-Up of Trypanosoma brucei gambiense Serology after Successful Treatment of Human African Trypanosomiasis: Results of Four Different Sero-Diagnostic Tests [PDF]
Diagnostics, 2022 Gambiense human African trypanosomiasis (gHAT), also known as gambiense sleeping sickness, is a parasitic infection caused by Trypanosoma brucei gambiense. During the last decades, gHAT incidence has been brought to an all-time low.
Raquel Inocencio da Luz +7 more
doaj +2 more sources
Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. [PDF]
PLoS Pathogens, 2014 Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Sam Alsford +4 more
doaj +2 more sources