Results 11 to 20 of about 4,641 (209)

Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense [PDF]

Nature Communications, 2022
Decreased functionality and expression of trypanosome haptoglobin-hemoglobin receptor (HpHbR) is one of the evolutionary modifications that have allowed Trypanosoma brucei gambiense to infect humans. Here, Horakova et al.
Eva Horáková, Laurence Lecordier, Paula Cunha, Roman Sobotka, Piya Changmai, Catharina J. M. Langedijk, Jan Van Den Abbeele, Benoit Vanhollebeke, Julius Lukeš   +8 more
doaj   +2 more sources

Target product profile: diagnostic test for Trypanosoma brucei gambiense [PDF]

Bulletin of the World Health Organization, 2023
Human African trypanosomiasis is a life-threatening parasitic infection endemic to sub-Saharan Africa. Around 95% of cases are due to Trypanosoma brucei gambiense, found in western and central Africa. Clinical signs and symptoms are nonspecific, current diagnostic tests are not sufficiently accurate, and parasitological confirmation of infection ...
Priotto, G., Franco, J. R., /Lejon, Veerle, Buscher, P., Matovu, E., Ndung'u, J., Bieler, S., Mumba, D., Van Reet, N., Verle, P., /Jamonneau, Vincent, Simarro, P. P., Ebeja, A. K., Sankara, D., Dagne, D. A.   +14 more
openaire   +3 more sources

Two-Year Follow-Up of Trypanosoma brucei gambiense Serology after Successful Treatment of Human African Trypanosomiasis: Results of Four Different Sero-Diagnostic Tests [PDF]

Diagnostics, 2022
Gambiense human African trypanosomiasis (gHAT), also known as gambiense sleeping sickness, is a parasitic infection caused by Trypanosoma brucei gambiense. During the last decades, gHAT incidence has been brought to an all-time low.
Raquel Inocencio da Luz, Sara Tablado Alonso, Philippe Büscher, Paul Verlé, Anja De Weggheleire, Dieudonné Mumba Ngoyi, Pati Patient Pyana, Epco Hasker   +7 more
doaj   +2 more sources

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. [PDF]

PLoS Pathogens, 2014
Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Sam Alsford, Rachel B Currier, José Afonso Guerra-Assunção, Taane G Clark, David Horn   +4 more
doaj   +2 more sources

A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense [PDF]

PLOS Neglected Tropical Diseases, 2016
Humans are protected against infection from most African trypanosomes by lipoprotein complexes present in serum that contain the trypanolytic pore-forming protein, Apolipoprotein L1 (APOL1). The human-infective trypanosomes, Trypanosoma brucei rhodesiense in East Africa and T. b.
Cooper, Anneli, Capewell, Paul, Clucas, Caroline, Veitch, Nicola, Weir, William, Thomson, Russell, Raper, Jayne, MacLeod, Annette   +7 more
openaire   +5 more sources

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis [PDF]

Insect Science, Volume 32, Issue 5, Page 1747-1760, October 2025.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +2 more sources

Evidence of the absence of human African trypanosomiasis in two northern districts of Uganda: Analyses of cattle, pigs and tsetse flies for the presence of Trypanosoma brucei gambiense. [PDF]

PLoS Neglected Tropical Diseases, 2020
BACKGROUND:Large-scale control of sleeping sickness has led to a decline in the number of cases of Gambian human African trypanosomiasis (g-HAT) to
Lucas J Cunningham, Jessica K Lingley, Iñaki Tirados, Johan Esterhuizen, Mercy Opiyo, Clement T N Mangwiro, Mike J Lehane, Stephen J Torr   +7 more
doaj   +2 more sources

African Trypanosomiasis Research at a Crossroads: Bibliometric and Systematic Insights for the Future [PDF]

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Aim Despite a reduction in the overall incidence and prevalence in the last two decades, trypanosomiasis continues to be a public health concern in Africa. This study was designed to comprehensively evaluate current trends in trypanosomiasis research using bibliometric approaches to uncover emerging topics and knowledge gaps, thereby guiding future ...
Israel Ogwuche Ogra, Jeremiah Zaphnathpaaneah Adaji, Emohchonne Utos Jonathan, Benita Kenechukwu Nwajiani, Samson Usman, Alexander Kurovsky, Kodjovi Sossou, Emmanuel Oluwadare Balogun, Pengfei Cai   +8 more
wiley   +2 more sources

Development of a camelid single-domain antibody-based antigen detection assay for the pan-specific diagnosis of active human and animal Trypanosoma brucei infections [PDF]

Journal of Clinical Microbiology
Trypanosoma brucei infections cause African trypanosomiasis, also known as sleeping sickness in humans and nagana in animals, presenting a significant global health and economic burden, especially in sub-Saharan Africa.
Zeng Li, Bo-kyung Jin, Emily Estefania Timaury Moreno, Andrés Álvarez-Rodríguez, Jo A. Van Ginderachter, Magdalena Radwanska, Yann G. -J. Sterckx, Benoit Stijlemans, Stefan Magez   +8 more
doaj   +2 more sources

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity [PDF]

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Alireza Mousavi, Martina Slapničková, Maryam Norouzbahari, Sarah D'Alessandro, Parham Foroumadi, Fariba Peytam, Federica Perego, Eva Doleželová, Zahra Emamgholipour, Maliheh Barazandeh Tehrani, Seyed Esmaeil Sadat‐Ebrahimi, Elahe Hosseinzadeh, Elmira Meghrazi Ahadi, Loghman Firoozpour, Hamidreza Bijanzadeh, Nicoletta Basilico, Alena Zíková, Alireza Foroumadi   +17 more
wiley   +2 more sources