Results 31 to 40 of about 72,583 (210)
Clinical Phytoscience, 2020 Objective The present study investigated the anti-Trypanosoma brucei brucei activity of methanolic extract of Senna occidentalis roots, leaves, stem bark, and seed in vitro and bioactive components of the most active plant part.
Zainab Aliyu Alhafiz +4 more
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Resolving Trypanosoma brucei Flagellar Structure by Cryo-Electron Tomography [PDF]
E3S Web of Conferences, 2019 Trypanosoma brucei is a unicellular eukaryote that can cause human African trypanosomiasis, which has continued to evolve and spread. The key feature of these parasites is that they have a flagellum consists of a typical 9 + 2 axoneme and a lattice-like ...
Dai Jennifer
doaj +1 more source
Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.
PLoS Neglected Tropical Diseases, 2021 Anemia caused by trypanosome infection is poorly understood. Autoimmunity during Trypanosoma brucei infection was proposed to have a role during anemia, but the mechanisms involved during this pathology have not been elucidated. In mouse models and human
Juan Rivera-Correa +5 more
doaj +1 more source
Trypanosoma brucei brucei is more pathogenic in rats compared to mice, making rats a better candidate for the relevant research studies [PDF]
The Iranian Journal of Veterinary Science and Technology, 2021 Trypanosomosis is an economically important disease that has raised great and diverse kinds of research using different types of animals. Hence, this study is aimed at determining the better laboratory animal between the Swiss albino mice and Wistar ...
Karimat Hussain +4 more
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Characterization of an endopeptidase of Trypanosoma brucei brucei
Archives of Biochemistry and Biophysics, 1992 A soluble 80-kDa endopeptidase has been isolated from Trypanosoma brucei brucei. The enzyme, which has a pI 5.1, is optimally active at about pH 8.2 and has apparent pKa values of 6.0 and greater than or equal to 10. It is inhibited by the serine protease inhibitor diisopropylfluorophosphate and by the serine protease mechanism-based inhibitor 3,4 ...
Kornblatt, M.J. +2 more
openaire +3 more sources
mBio, 2013 Human African trypanosomiasis is caused by two subspecies of Trypanosoma brucei. Trypanosoma brucei rhodesiense is found in East Africa and frequently causes acute disease, while Trypanosoma brucei gambiense is found in West Africa and is associated with
Ian Goodhead +10 more
doaj +1 more source
P-type transport ATPases in Leishmania and Trypanosoma
Parasite, 2019 P-type ATPases are critical to the maintenance and regulation of cellular ion homeostasis and membrane lipid asymmetry due to their ability to move ions and phospholipids against a concentration gradient by utilizing the energy of ATP hydrolysis.
Meade John C.
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mBio, 2022 Trypanosoma brucei gambiense is the primary causative agent of human African trypanosomiasis (HAT), a vector-borne disease endemic to West and Central Africa.
Jaime So +9 more
doaj +1 more source
Parasites & Vectors, 2014 Background Human African Trypanosomiasis is still a public health threat in Cameroon. To assess Trypanosoma brucei strains circulating in the Fontem sleeping sickness focus, we conducted a genetic structure study using microsatellites to assess genotypes
Gustave Simo +5 more
doaj +1 more source
An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei [PDF]
, 2015 Elucidating the mechanism of action of trypanocidal compounds is an important step in the development of more efficient drugs against Trypanosoma brucei. In a screening approach using an RNAi library in T. brucei bloodstream forms, we identified a member
Vial, Henri +28 more
core +3 more sources