Results 51 to 60 of about 75,660 (213)

Threonine Catabolism in Trypanosoma brucei [PDF]

Journal of General Microbiology, 1977
L-Threonine is catabolized by Trypanosoma brucei to give equimolar quantities of glycine and acetate. The pathway, which involves the two enzymes L-threonine dehydrogenase (EC 1.1.1.103) and aminoacetone synthase (acetyl-CoA:glycine C-acetyltransferase, EC 2.3.1.29) and subsequent hydrolysis of the acetyl-CoA, is most active in cultured trypanosomes ...
D J, Linstead, R A, Klein, G A, Cross
openaire   +2 more sources

The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic Human African Trypanosomiasis [PDF]

, 2010
<p><b>Background:</b> <i>Trypanosoma brucei gambiense</i> is the causative agent of chronic Human African Trypanosomiasis or sleeping sickness, a disease endemic across often poor and rural areas of Western and Central ...
Martin A Aslett, Hertz-Fowler Christiane, Chukualim, B., Gibson, W., Melville, S.E., Jackson Andrew P., Jackson, A.P., Jackson, A., Capewell, P., Sanders Mandy, Annette MacLeod, McQuillan, J, Quail, M.A., MacLeod Annette, Melville Sara E., Melville, S., McQuillan, J., Paul Capewell, Aslett Martin A., Bridget Chukualim, MacLeod, A., Aslett, M., Hertz-Fowler, C., McQuillan Jacqueline, Aslett, M.A., Mandy Sanders, Berry Andrew, Michael A Quail, Barry, J.D., Berriman, M., Sanders, M., Wendy Gibson, Sara E Melville, Jacqueline McQuillan, Gibson, WC, Quail Michael A., Berry, A., J David Barry, Andrew P Jackson, Andrew Berry, Christiane Hertz-Fowler, Matthew Berriman, Chukualim Bridget, Gibson Wendy, Barry J. David, Capewell Paul, Berriman Matthew   +46 more
core   +1 more source

In vitro Anti-trypanosomal Activity of Ethanolic and n-Hexane Extracts of Hymenocardia acida Stem Bark against Trypanosoma brucei brucei and Trypanosoma congolense

UMYU Journal of Microbiology Research
The development of resistance by trypanosomes to existing trypanocidal drugs necessitates the need to search for safer and more effective alternative drugs with a broad spectrum of activity.
Lawal, S. M., Inabo, H. I., Ella, E. E., Okubanjo, O. O.   +3 more
doaj   +1 more source

Rescue of pATOM36‐depleted T. brucei by human MTCH1/2 reveals common features of protein insertases

The FEBS Journal, EarlyView.
Human MTCH1 and MTCH2 (with an N‐terminal extension) functionally complement the loss of pATOM36 in T. brucei, indicating that these evolutionarily distant proteins recognize a common set of substrates and share fundamental principles of mitochondrial outer membrane protein insertion. Structural analyses reveal a common hydrophilic cavity, supporting a
Stephan Berger, Markus Daniel Gerber, Torsten Ochsenreiter, Christoph von Ballmoos, André Schneider   +4 more
wiley   +1 more source

Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi. [PDF]

, 2007
BACKGROUND: Trypanosomes are parasitic protozoa that diverged early from the main eukaryotic lineage. Their genomes display several unusual characteristics and, despite completion of the trypanosome genome projects, the location of centromeric DNA has ...
Bot, Christopher, Nilsson, D,, Nilsson, Daniel, Andersson, B,, Andersson, Bjorn, Bot, C,, Obado, SO, Obado, Samson O, Kelly, JM, Kelly, John M, Daniel Nilsson, John M Kelly, Bjorn Andersson, Christopher Bot, Samson O Obado   +14 more
core   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

Trypanosoma brucei: meet the system [PDF]

Current Opinion in Microbiology, 2014
African trypanosomes cause devastating diseases in humans and domestic animals. The parasites evolved early in the eukaryotic lineage and have numerous biochemical peculiarities that distinguish them from other systems. These include unconventional mechanisms for expressing nuclear and mitochondrial genes as well as unusual subcellular localizations ...
Fiona, Achcar, Eduard J, Kerkhoven, Michael P, Barrett   +2 more
openaire   +2 more sources

Analytical purification of a 60-kDa target protein of artemisinin detected in Trypanosoma brucei brucei

Data in Brief, 2015
Here we describe the isolation and purity determination of Trypanosoma brucei (T. b.) brucei candidate target proteins of artemisinin. The candidate target proteins were detected and purified from their biological source (T. b.
Benetode Konziase
doaj   +1 more source

Plant NAOGAT (ArgJ) Structure Reveals Mechanism of Ornithine Biosynthesis, Preference for Acetylornithine and Susceptibility to Mangotoxin

Plant, Cell &Environment, Volume 49, Issue 12, Page 10283-10300, December 2026.
ABSTRACT Arginine metabolism in plants is targeted by phytopathogens such as Pseudomonas syringae strains, which produce toxins that affect enzymes of plant arginine metabolism, causing devastating infections in crops. In this work, the structural and functional properties of plant N‐acetylornithine glutamate acetyltransferase (NAOGAT), the key ...
Maciej Nielipinski, Agnieszka J. Pietrzyk‐Brzezinska, Aleksandra Twarda‐Clapa, Bartosz Sekula   +3 more
wiley   +1 more source

Expression of procyclin mRNAs during cyclical transmission of Trypanosoma brucei [PDF]

, 2005
<i>Trypanosoma brucei</i>, the parasite causing human sleeping sickness, relies on the tsetse fly for its transmission. In the insect, EP and GPEET procyclins are the major surface glycoproteins of procyclic (midgut) forms of the parasite ...
J. David Barry, Blundell, Pat, Erik Vassella, Isabel Roditi, Blundell, P., Simon Urwyler, Abbeele Jan Van Den, Urwyler, Simon, Pat Blundell, Roditi Isabel, Vassella, Erik, Barry, J. David, Barry, J. D., Kunz Renggli, Christina, Abbeele, Jan Van Den, Barry, J.D., Roditi, Isabel, Jan Van Den Abbeele, Urwyler Simon, J David Barry, Van den Abbeele, J., Roditi, I., Abbeele, J.V.D., Kunz Renggli, C., Renggli Christina Kunz, Christina Kunz Renggli, Barry J. David, Vassella, E., Urwyler, S., Vassella Erik, Blundell Pat, Vassella E, Van Den Abbeele J, Roditi I, Urwyler S, Barry JD, Renggli CK, Blundell P   +37 more
core   +3 more sources