Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors : toward the development of novel therapies for African sleeping sickness [PDF]
, 2010 Trypanosoma brucei, the causative agent of human African trypanosomiasis, affects tens of thousands of sub-Saharan Africans. As current therapeutics are inadequate due to toxic side effects, drug resistance, and limited effectiveness, novel therapies are
Durrant, Jacob D. +3 more
core +4 more sources
Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria
Parasites & Vectors, 2019 Background Animal trypanosomosis is endemic in Nigeria, while the human disease caused by Trypanosoma brucei gambiense is rarely reported nowadays after efforts to bring it under control in the 20th century.
Paschal Ugochukwu Umeakuana +3 more
doaj +1 more source
Edelfosine (ET-18-OCH3) a Promising Alkylphospholipid against Resistant Trichomonas vaginalis
Proceedings, 2017 Edelfosine (ET-18-OCH3) is an alkylphospholipid with an analogous structure to miltefosine. Both molecules are active against kinetoplastids (Leishmania spp., Trypanosoma cruzi and Trypanosoma brucei). [...]
Alexandra Ibáñez-Escribano +3 more
doaj +1 more source
mSphere, 2021 Sleeping sickness is a neglected tropical disease caused by the protozoan parasite Trypanosoma bruceiT ...
Daniel E. Vélez-Ramírez +9 more
doaj +1 more source
HIV‐associated nephropathy: A decade of clinical outcomes, global disparities and emerging promise
HIV Medicine, Volume 27, Issue 11, Page 1753-1762, November 2026.Abstract Objective To review the pathogenesis, epidemiology, clinical presentation, management and outcomes of HIV‐associated nephropathy (HIVAN), with emphasis on global disparities, genetic susceptibility (APOL1) and emerging therapeutic and technological advances.
Deepak V. Pathiyil +4 more
wiley +1 more source
Structure of thioredoxin from Trypanosoma brucei brucei
FEBS Letters, 2003 The three‐dimensional structure of thioredoxin from Trypanosoma brucei brucei has been determined at 1.4 Å resolution. The overall structure is more similar to that of human thioredoxin than to any other thioredoxin structure. The most striking difference to other thioredoxins is the absence of a buried carboxylate behind the active site cysteines ...
Friemann, Rosmarie +5 more
openaire +2 more sources
Genetic exchange in Trypanosoma brucei: evidence for mating prior to metacyclic stage development [PDF]
, 2005 It is well established that genetic exchange occurs between Trypanosoma brucei parasites when two stocks are used to infect tsetse flies under laboratory conditions and a number of such crosses have been undertaken.
Turner, C.M.R. +4 more
core +1 more source
Réponse du poulet nigérian local ( Gallus domesticus) aux trypanosomes
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1988 La réponse du poulet nigérian local aux souches de Trypanosoma brucei 8/18 et T. vivax Y58 a été recherchée. Le poulet local utilisé dans cette étude était sensible à T. brucei mais réfractaire à T. vivax (Y58) (une souche adaptée aux rongeurs).
O.A. Dina, R.O.A. Arowolo
doaj +1 more source
FEBS Open Bio, Volume 16, Issue 10, Page 1974-1981, October 2026.The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]
, 2014 It is well known that several anti-trypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
Schnaufer, Achim; id_orcid +1 more
core +1 more source