Results 81 to 90 of about 75,660 (213)
Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1686-1701, October 2026.ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva +10 more
wiley +1 more source
Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by Trypanolytic factor 1 [PDF]
, 2011 <p><b>Background:</b> The three sub-species of <i>Trypanosoma brucei</i> are important pathogens of sub-Saharan Africa. <i>T. b.
C. Michael R. Turner +30 more
core +1 more source
Coumarin‐Benzimidazole Hybrids as Multitarget Scaffolds for Antileishmanial Drug Discovery
ChemistrySelect, Volume 11, Issue 38, 13 October 2026.Coumarin‐benzimidazole hybrids emerge as promising antileishmanial agents through virtual screening against essential Leishmania enzymes, Cathepsin B (CatB), and N‐myristoyltransferase (NMT). Molecular docking and dynamics simulations reveal highly stable target interactions that surpass the reference drug miltefosine (MTF).
Fernanda Melo Jucá +4 more
wiley +1 more source
Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty. [PDF]
, 2015 Two key biological features distinguish Trypanosoma evansi from the T. brucei group: independence from the tsetse fly as obligatory vector, and independence from the need for functional mitochondrial DNA (kinetoplast or kDNA).
Hideo Imamura (62469) +113 more
core +1 more source
Trypanosoma brucei infection protects mice against malaria.
PLoS Pathogens, 2019 Sleeping sickness and malaria are parasitic diseases with overlapping geographical distributions in sub-Saharan Africa. We hypothesized that the immune response elicited by an infection with Trypanosoma brucei, the etiological agent of sleeping sickness,
Margarida Sanches-Vaz +8 more
doaj +1 more source
Synthesis of biotinylated probes of artemisinin for affinity labeling
Data in Brief, 2015 In this data article, we described the synthetic routes to four biotinylated probes (2, 3, 4, and 5) of artemisinin and the associated experimental procedures. We also provided the physical data for the synthesized compounds.
Benetode Konziase
doaj +1 more source
TAXON, Volume 75, Issue 5, October 2026.Abstract DNA sequences of loricate euglenids (genera Strombomonas and Trachelomonas) were analyzed in conjunction with detailed examinations of lorica and monad morphology. Phylogenetic analyses were conducted using 342 new sequences representing three molecular markers (149 nSSU, 102 nLSU, 91 cpSSU rDNA).
Alicja Fells +3 more
wiley +1 more source
Onderstepoort Journal of Veterinary Research, 2004 The protective efficacy of isometamidium chloride (ISMM) and diminazene aceturate (DIM) against Trypanosoma brucei, Trypanosoma congolense and Trypanosoma vivax infections in cattle under a suppressed tsetse population was assessed in southeast Uganda.
J.W. Magona +3 more
doaj +1 more source
Molecular Microbiology, Volume 126, Issue 4, Page 396-411, October 2026.The mitochondrial membrane‐shaping machinery MICOS is assembled surprisingly early during the life cycle of Trypanosoma brucei, before the mitochondrion acquires its mature architecture or full respiratory capacity. Our study also identifies two previously uncharacterized proteins associated with MICOS, providing new insight into the early organization
Michala Boudová +5 more
wiley +1 more source