Results 71 to 80 of about 75,660 (213)

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source

Telomere length in Trypanosoma brucei [PDF]

Experimental Parasitology, 2008
Trypanosoma brucei thwarts the host immune response by replacing its variant surface glycoprotein (VSG). The actively transcribed VSG is located in one of approximately 20 telomeric expression sites (ES). Antigenic variation can occur by transcriptional switching, reciprocal translocations, or duplicative gene conversion events among ES or with the ...
Oliver, Dreesen, George A M, Cross
openaire   +2 more sources

TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei [PDF]

, 2014
The procyclic form of Trypanosoma brucei expresses procyclin surface glycoproteins with unusual glycosylphosphatidylinositol-anchor side chain structures that contain branched N-acetyllactosamine and lacto-N-biose units.
Hashida, Kazunori, Nakanishi, Masayuki, Karasudani, Moe, Nomoto, Hiroshi, Hino, Mami, Ferguson, Michael A. J; id_orcid, Shiraishi, Takahiro   +6 more
core   +1 more source

Traditional Uses, Phytochemistry, and Multi‐Target Pharmacological Activities of Senna alexandrina

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Senna alexandrina is a medicinally important plant with documented use across Traditional Chinese, Islamic, Ayurvedic, and Unani medicine systems. Phytochemical investigations have yielded 219 characterized compounds, predominantly anthraquinones, flavonoids, and polysaccharides, distributed across leaves, pods, and aerial parts.
Diana Afrina Rella, Khai‐Lin Hew, Yeun‐Mun Choo   +2 more
wiley   +1 more source

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei [PDF]

, 2010
Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K., Young, Simon A., Young, Simon Alan, Smith, Terry K.; id_orcid, Young, Simon A.; id_orcid   +4 more
core   +1 more source

Identification of novel components of Trypanosoma brucei editosomes [PDF]

, 2003
The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei.
Schnaufer, Achim; id_orcid, Wang, Bingbing, Salavati, Reza, Stuart, Kenneth, Carmean, Nicole, Panigrahi, Aswini K, Ernst, Nancy L   +6 more
core   +1 more source

Association between IL1 gene polymorphism and human African trypanosomiasis in populations of sleeping sickness foci of southern Cameroon. [PDF]

PLoS Neglected Tropical Diseases, 2019
BACKGROUND:Human African Trypanosomiasis (HAT) is a neglected tropical disease caused by infections due to Trypanosoma brucei subspecies. In addition to the well-established environmental and behavioural risks of becoming infected, there is evidence for ...
Elvis Ofon, Harry Noyes, Vincent Ebo'o Eyanga, Flobert Njiokou, Mathurin Koffi, Pythagore Fogue, Christiane Hertz-Fowler, Annette MacLeod, Enock Matovu, Gustave Simo, TrypanoGEN Research Group, as members of The H3Africa Consortium   +10 more
doaj   +1 more source

Harnessing Extracellular Vesicles for Precision Diagnostics and Infectious Disease Management: Integrating Host‐ and Pathogen‐Derived Cues

Exploration, Volume 6, Issue 5, October 2026.
This review summarizes the diagnostic and monitoring potential of host‐pathogen extracellular vesicles (hpEVs) in infectious diseases, advances in their isolation and analysis, and challenges to clinical translation. ABSTRACT Conventional infectious disease diagnostics often rely on detecting pathogen‐derived factors or an immune response directed ...
Ming Zhou, Yongchun Pan, Bo Ning, Christopher J. Lyon, Yang Liu, Tony Hu   +5 more
wiley   +1 more source

A bacterial protein inhibitor of dUTPase disrupts zebrafish embryogenesis through a conserved active‐site mechanism

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Deoxyuridine triphosphatase (dUTPase) is essential for DNA replication fidelity and embryonic development in metazoa, yet whether a protein inhibitor can acutely disrupt dUTPase function in a living vertebrate has not been tested. The Staphylococcus aureus Stl protein inhibits diverse dUTPases in vitro, but its efficacy in a eukaryotic ...
Viktória Perey‐Simon, Zoé Sára Tóth, Dániel Dombovári, Latifa Kazzazy, Máté Varga, Beáta G. Vértessy, Gergely Nándor Nagy, Kinga Nyíri   +7 more
wiley   +1 more source

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. [PDF]

, 2014
The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions.
Opperdoes, F.R. (Fred), van Hellemond, JJ, de Koning, HP, Nes, D. W.,, Nayak, A.,, Silva-Franco, F.,, de, Koning HP, Wyllie, S, Ebikeme, C., van Hellemond, Jaap; id_orcid, van Hellemond, J. J.,, Crouch, Kathryn, Ferguson, Michael A.J., Nolan, D. P.,, Bütikofer, P. (Peter), Nolan, Derek P., Barrett, Michael P, Ebikeme, C. (Charles), Olsen, C, De Koning, H.P. (Harry P.), Jourdan, F., Vinson, F. (Florence), Bütikofer, P, Ferguson, MA, Ferguson, Michael A. J., Mäser, P, Butikofer, P., Opperdoes, F. R., Breitling, R., Nayak, A, Achcar, F., Smith, Terry K., Ferguson, MAJ, Boshart, M., Boshart, M, Denise, H., Logan-Klumpler, F. J.,, Cattanach, A. M.,, Taylor, M. C., Wyllie, S. (Susan), Hertz-Fowler, C., Creek, D.J. (Darren J.), Silva-Franco, F, Nes, DW, LS Biochemie van parasieten, Smith, TK, Kerkhoven, E. J., Crouch, K, Wyllie, S., Merlet, B.,, Vincent, Isabel M., Olsen, C., Tielens, A.G.M. (Lodewijk), Regenerative Medicine, Stem Cells & Cancer, Merlet, Benjamin, Taylor, M. C.,, Cottret, L., Creek, DJ, Opperdoes, FR, Ferguson, Michael AJ, Berriman, M, Opperdoes, Fred R., Logan-Klumpler, FJ, Achcar, Fiona, Barrett, M. P., Breitling, R, Urbaniak, Michael D., Denise, H. (Hubert), Fairlamb, Alan H, Merlet, B, Boshart, Michael, Fairlamb, A. H.,, Wilkinson, SR, Taylor, MC, Urbaniak, Michael D, Crouch, K.,, Breitling, R.,, Vincent, I.M. (Isabel M.), Tielens, Aloysius G M, Breitling, R. (Rainer), Boshart, M. (Michael), de Koning, Harry P, Smith, T. K.,, Michels, PA, de Koning, H. P.,, Nes, David W., Ginger, ML, Butikofer, P.,, Barrett, M. P.,, Hertz-Fowler, Christiane, Bannerman-Chukualim, B., Hertz-Fowler, C.,, Fairlamb, Alan H., Ebikeme, C, Michels, Paul A. M., Tielens, A. G. M., Taylor, Martin C, Nolan, Derek P, Maeser, P, Boshart, M.,, Taylor, Martin C., Hertz-Fowler, C, Nayak, A. (Archana), Shameer, Sanu, Ferguson, M. A. J.,, Tielens, Aloysius G.M., Cattanach, Amy M., Crouch, K., Fairlamb, Alan H.; id_orcid, Urbaniak, MD, Jourdan, F, Ferguson, Michael A. J.; id_orcid, Berriman, M., Bringaud, Frédéric, Bannerman-Chukualim, B. (Bridget), Wyllie, S.,, Silva-Franco, F. (Fatima), Wilkinson, S. R., Silva-Franco, F., Shameer, S, Bringaud, F. (Frédéric), Bannerman-Chukualim, Bridget, Michels, Paul A.M., Ginger, M. L.,, Nes, David W, Shameer, S.,, van Hellemond, Jaap J., Ferguson, M. A. J., van Hellemond, J. J., Urbaniak, M.D. (Michael D.), Nolan, D.P. (Derek P.), Wilkinson, S. R.,, Creek, Darren J., Merlet, B., Mäser, Pascal, Michels, Paul AM, Cattanach, A.M. (Amy M.), Tielens, AG, Barrett, Michael P., Jourdan, Fabien, Wyllie, Susan, Fairlamb, AH, Bringaud, F.,, Kerkhoven, Eduard J, Maeser, Pascal, Vinson, F., Bringaud, F., Creek, D. J., Berriman, M. (Matthew), Tielens, AGM, Logan-Klumpler, Flora J, Shameer, S. (Sanu), Achcar, F.,, Michels, P. A. M., Koning, Harry P. de, Logan-Klumpler, F. J., Fairlamb, A. H., Vincent, IM, Nayak, A., Logan-Klumpler, Flora J., Bütikofer, Peter, Shameer, S., Olsen, C. (Christian), Cottret, Ludovic, Ebikeme, Charles, Cottret, L.,, Nolan, DP, Michels, PAM, Tielens, A. G. M.,, Opperdoes, F. R.,, Silva-Franco, Fatima, Kerkhoven, E.J. (Eduard), Berriman, M.,, Maser, P.,, van Hellemond, Jaap J, Urbaniak, M. D., Ginger, M.L. (Michael L.), Michels, P.A.M. (Paul), Kerkhoven, EJ, Creek, D. J.,, Maser, P., Mäser, P. (Pascal), Kerkhoven, Eduard J., Merlet, B. (Benjamin), Fairlamb, A.H. (Alan H.), Achcar, F. (Fiona), Smith, T.K. (Terry K.), de Koning, H. P., Urbaniak, M. D.,, Nes, D. (DavidW.), Crouch, K. (Kathryn), Denise, H, Bannerman-Chukualim, B.,, Jourdan, F. (Fabien), Ginger, M. L., Berriman, Matthew, Tielens, Aloysius GM, Jourdan, F.,, Achcar, F, Ebikeme, C.,, Olsen, Christian, Wilkinson, Shane R, Cottret, L. (Ludovic), Hertz-Fowler, C. (Christiane), Hellemond, Jaap J. van, Kerkhoven, Eduard,, Ginger, Michael L., Ferguson, M.A.J. (Michael A. J.), Cottret, L, Vincent, I. M., Nes, D. W., Barrett, MP, de Koning, Harry P., Michels, P. A. M.,, Cattanach, Amy M, Cattanach, AM, Hellemond, J.J. (Jaap) van, Michels, Paul A M, Nolan, D. P., Wilkinson, S.R. (Shane R.), Vinson, F.,, Wilkinson, Shane R., Breitling, Rainer, Creek, Darren J, Barrett, M.P. (Michael P.), B&C BRC-SIB-TR, Tielens, Lodewijk; id_orcid, Vinson, Florence, Tielens, Aloysius G. M., Bringaud, F, Vincent, Isabel M, Logan-Klumpler, F.J. (Flora J.), Opperdoes, Fred R, Denise, H.,, Vincent, I. M.,, Olsen, C.,, van, Hellemond JJ, Ginger, Michael L, Kerkhoven, Eduard, Denise, Hubert, Smith, T. K., Taylor, M.C. (Martin C.), Vinson, F, Nayak, Archana, Ferguson, Michael A J, Smith, Terry K, Bannerman-Chukualim, B, Cattanach, A. M., Michels PA, Breitling R, Achcar F, Smith TK, Jourdan F, Bannerman-Chukualim B, Merlet B, Denise H, Vinson F, Ginger ML, Shameer S, Mäser P, Olsen C, Ferguson MA, Taylor MC, Opperdoes FR, de Koning HP, Creek DJ, Barrett MP, Ebikeme C, Hertz-Fowler C, van Hellemond JJ, Cattanach AM, Silva-Franco F, Boshart M, Bütikofer P, Cottret L, Bringaud, Fredrric, Nayak A, Logan-Klumpler FJ, Vincent IM, Nes DW, Breitling, R; id_orcid, Wilkinson SR, Wyllie S, Bringaud F, Tielens AG, Kerkhoven EJ, Nolan DP, Fairlamb AH, Berriman M, Crouch K, Urbaniak MD, Smith, Terry K; id_orcid   +291 more
core   +2 more sources