Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei [PDF]
Trypanosoma brucei expresses a diverse repertoire of N-glycans, ranging from oligomannose and paucimannose structures to exceptionally large complex N-glycans.
Damerow, Manuela +5 more
core +1 more source
The plant Pomegranate (Punica granatum Linn.) selected for this study is native to the region of Eurasia. The objective of this study was to evaluate the antitrypanosomal potential of the plant against Trypanosoma brucei brucei (T.b.
Muhammad Muhsin Fathuddin +1 more
doaj +1 more source
Animal African trypanosomiasis (AAT) is a significant food security and economic burden in sub-Saharan Africa. Current AAT empirical and immunodiagnostic surveillance tools suffer from poor sensitivity and specificity, with blood sampling requiring ...
Isabel Saldanha +10 more
doaj +1 more source
Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from northwestern Uganda following melarsoprol withdrawal [PDF]
Human African trypanosomiasis (HAT) manifests as a chronic infection caused by <i>Trypanosoma brucei gambiense</i>, or as a more acute form due to <i>T. b. rhodesiense</i>.
Barbara Nerima +24 more
core +1 more source
Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]
Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor, Nathalie +5 more
core +1 more source
Résistance médicamenteuse d'isolats récents de Trypanosoma brucei et Trypanosoma congolense
Des études ont été menées sur des souris pour déterminer la sensibilité aux médicaments d’isolats récents de Trypanosoma brucei et Trypanosoma congolense. Chacune des onze souches de T. congolense et des cinq souches de T. brucei, toutes isolées sur des
R.A. Joshua
doaj +1 more source
Phylogeography and Taxonomy of Trypanosoma brucei
Characterizing the evolutionary relationships and population structure of parasites can provide important insights into the epidemiology of human disease.We examined 142 isolates of Trypanosoma brucei from all over sub-Saharan Africa using three distinct classes of genetic markers (kinetoplast CO1 sequence, nuclear SRA gene sequence, eight nuclear ...
Balmer, O +3 more
openaire +6 more sources
An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]
RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid +4 more
core +1 more source
The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei [PDF]
Funded by Wellcome Trust: Senior Research Fellowship, Grant Number: 067441 and Wellcome Trust, Grant Numbers: 082596, 093228.Lipid metabolism in Trypanosoma brucei, the causative agent of African sleeping sickness, differs from its human host in several ...
Lilley, Alison C. +10 more
core +1 more source
The developmental cell biology of Trypanosoma brucei [PDF]
Trypanosoma brucei provides an excellent system for studies of many aspects of cell biology, including cell structure and morphology, organelle positioning, cell division and protein trafficking. However, the trypanosome has a complex life cycle in which
Matthews, Keith R; id_orcid +1 more
core +1 more source

