Results 21 to 30 of about 75,630 (213)

Characterization of an endopeptidase of Trypanosoma brucei brucei

Archives of Biochemistry and Biophysics, 1992
A soluble 80-kDa endopeptidase has been isolated from Trypanosoma brucei brucei. The enzyme, which has a pI 5.1, is optimally active at about pH 8.2 and has apparent pKa values of 6.0 and greater than or equal to 10. It is inhibited by the serine protease inhibitor diisopropylfluorophosphate and by the serine protease mechanism-based inhibitor 3,4 ...
Kornblatt, M.J., Mpimbaza, G.W.N., Lonsdale-Eccles, J.D.   +2 more
openaire   +3 more sources

Whole-Genome Sequencing of Trypanosoma brucei Reveals Introgression between Subspecies That Is Associated with Virulence

mBio, 2013
Human African trypanosomiasis is caused by two subspecies of Trypanosoma brucei. Trypanosoma brucei rhodesiense is found in East Africa and frequently causes acute disease, while Trypanosoma brucei gambiense is found in West Africa and is associated with
Ian Goodhead, Paul Capewell, J. Wendi Bailey, Tanja Beament, Michael Chance, Suzanne Kay, Sarah Forrester, Annette MacLeod, Mark Taylor, Harry Noyes, Neil Hall   +10 more
doaj   +1 more source

Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.

PLoS Neglected Tropical Diseases, 2021
Anemia caused by trypanosome infection is poorly understood. Autoimmunity during Trypanosoma brucei infection was proposed to have a role during anemia, but the mechanisms involved during this pathology have not been elucidated. In mouse models and human
Juan Rivera-Correa, Joseph Verdi, Julian Sherman, Jeremy M Sternberg, Jayne Raper, Ana Rodriguez   +5 more
doaj   +1 more source

Lipidomic analysis of bloodstream and procyclic form Trypanosoma brucei [PDF]

, 2010
The biological membranes of Trypanosonza brucei contain a complex array of phospholipids that are synthesized de novo from precursors obtained either directly from the host, or as catabolised endocytosed lipids.
Gibellini, Federica, TERRY K. SMITH, FEDERICA GIBELLINI, Lilley, Alison, SIMON A. YOUNG, Richmond, Gregory S., Major, Louise, Denton, Helen, Smith, Terry K, HELEN DENTON, Young, Simon A., GREGORY S. RICHMOND, LOUISE MAJOR, ALISON LILLEY, Young, Simon A.; id_orcid, Smith, Terry K; id_orcid, Major, Louise; id_orcid   +16 more
core   +1 more source

Characterization of Trypanosoma brucei gambiense variant surface glycoprotein LiTat 1.5 [PDF]

, 2012
At present, all available diagnostic antibody detection tests for Trypanosoma brucei gambiense human African trypanosomiasis are based on predominant variant surface glycoproteins (VSGs), such as VSG LiTat 1.5. During investigations aiming at replacement
Rogé, S., Lejon, V., Guisez, Y., Van Nieuwenhove, L., Büscher, P., Rog\ue9, S.   +5 more
core   +1 more source

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

International Journal for Parasitology: Drugs and Drug Resistance, 2015
Aquaglyceroporin-2 is a known determinant of melarsoprol–pentamidine cross-resistance in Trypanosoma brucei brucei laboratory strains. Recently, chimerization at the AQP2–AQP3 tandem locus was described from melarsoprol–pentamidine cross-resistant ...
Fabrice E. Graf, Nicola Baker, Jane C. Munday, Harry P. de Koning, David Horn, Pascal Mäser   +5 more
doaj   +1 more source

The lysis of Trypanosoma brucei brucei by human serum [PDF]

Nature Biotechnology, 1996
The natural immunity of humans to the cattle pathogen Trypanosoma brucei brucei, but not to the morphologically indistinguishable human pathogens T. brucei gambiense and T. brucei rhodesiense, is due to the selective killing of the parasite by normal human serum. The factor in human serum that mediates lysis of T. brucei brucei has long been attributed
S, Tomlinson, J, Raper
openaire   +2 more sources

Utilisation des glucides et de leurs produits de métabolisme par Trypanosoma evansi et Trypanosoma brucei

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1964
Après avoir rappelé brièvement les connaissances actuelles sur le métabolisme glucidique de Trypanosoma evansi et Trypanosoma brucei, l'auteur expose les résultats obtenus par deux méthodes originales.
J. Balis
doaj   +1 more source

Antigenic variation in Trypanosoma brucei: joining the DOTs [PDF]

, 2008
African trypanosomes, such as <i>Trypanosoma brucei</i>, are protistan parasites that cause sleeping sickness. Though first described more than a century ago, trypanosomes remain a blight on the health of the human population and on the ...
Swiderski, Michal R., J David Barry, McCulloch, Richard, Michal R Swiderski, Chris Stockdale, McCulloch Richard, Barry, J. David, Stockdale Chris, Barry J. David, Stockdale, Chris, Richard McCulloch, Swiderski Michal R   +11 more
core   +1 more source

Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis.

PLoS Pathogens, 2021
Human African Trypanosomiasis (HAT) has been responsible for several deadly epidemics throughout the 20th century, but a renewed commitment to disease control has significantly reduced new cases and motivated a target for the elimination of Trypanosoma ...
Alexandre Girard, Anneli Cooper, Samuel Mabbott, Barbara Bradley, Steven Asiala, Lauren Jamieson, Caroline Clucas, Paul Capewell, Francesco Marchesi, Matthew P Gibbins, Franziska Hentzschel, Matthias Marti, Juan F Quintana, Paul Garside, Karen Faulds, Annette MacLeod, Duncan Graham   +16 more
doaj   +1 more source