Results 21 to 30 of about 22,441 (186)

Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis.

PLoS Pathogens, 2021
Human African Trypanosomiasis (HAT) has been responsible for several deadly epidemics throughout the 20th century, but a renewed commitment to disease control has significantly reduced new cases and motivated a target for the elimination of Trypanosoma ...
Alexandre Girard, Anneli Cooper, Samuel Mabbott, Barbara Bradley, Steven Asiala, Lauren Jamieson, Caroline Clucas, Paul Capewell, Francesco Marchesi, Matthew P Gibbins, Franziska Hentzschel, Matthias Marti, Juan F Quintana, Paul Garside, Karen Faulds, Annette MacLeod, Duncan Graham   +16 more
doaj   +1 more source

The exopolyphosphatase TbrPPX1 of Trypanosoma brucei [PDF]

BMC Microbiology, 2011
Abstract Background Exopolyphosphatases and pyrophosphatases play important but still incompletely understood roles in energy metabolism, and also in other aspects of cell biology such as osmoregulation or signal transduction.
Luginbuehl, Edith, Kunz, Stefan, Wentzinger, Laurent, Freimoser, Florian, Seebeck, Thomas   +4 more
openaire   +5 more sources

Population genetics of Trypanosoma brucei circulating in Glossina palpalis palpalis and domestic animals of the Fontem sleeping sickness focus of Cameroon

Parasites & Vectors, 2014
Background Human African Trypanosomiasis is still a public health threat in Cameroon. To assess Trypanosoma brucei strains circulating in the Fontem sleeping sickness focus, we conducted a genetic structure study using microsatellites to assess genotypes
Gustave Simo, Guy Roger Njitchouang, Tresor Tito Tanekou Melachio, Flobert Njiokou, Gerard Cuny, Asonganyi Tazoacha   +5 more
doaj   +1 more source

Anti-trypanosomal activity and DNA fingerprinting of fifteen Euphorbia species using ISSR and SCoT markers

Beni-Suef University Journal of Basic and Applied Sciences, 2021
Background Euphorbia is the largest genus in family Euphorbiaceae with a great biological and genetic diversity. The anti-trypanosomal activity of the crude extract of 15 Euphorbia species against Trypanosoma brucei brucei was carried out.
Seham S. El-Hawary, Nadia M. Lithy, Elham Amin, Sameh F. AbouZid, Rabab Mohammed   +4 more
doaj   +1 more source

P-type transport ATPases in Leishmania and Trypanosoma

Parasite, 2019
P-type ATPases are critical to the maintenance and regulation of cellular ion homeostasis and membrane lipid asymmetry due to their ability to move ions and phospholipids against a concentration gradient by utilizing the energy of ATP hydrolysis.
Meade John C.
doaj   +1 more source

Phosphorylation-dependent protein interaction with Trypanosoma brucei 14-3-3 proteins that display atypical target recognition. [PDF]

PLoS ONE, 2010
BACKGROUND: The 14-3-3 proteins are structurally conserved throughout eukaryotes and participate in protein kinase signaling. All 14-3-3 proteins are known to bind to evolutionally conserved phosphoserine-containing motifs (modes 1 and/or 2) with high ...
Masahiro Inoue, Kouichi Yasuda, Haruki Uemura, Natsumi Yasaka, Hiroshi Inoue, Yoshitatsu Sei, Nobuo Horikoshi, Toshihide Fukuma   +7 more
doaj   +1 more source

SUMOylation in Trypanosoma brucei

PeerJ, 2013
Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress.
Klein, Cornelia Andrea, Droll, Dorothea, Clayton, Christine   +2 more
openaire   +4 more sources

Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis

Microbial Cell, 2014
Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal
Sam Alsford
doaj   +1 more source

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei.

PLoS Pathogens, 2014
Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Sam Alsford, Rachel B Currier, José Afonso Guerra-Assunção, Taane G Clark, David Horn   +4 more
doaj   +1 more source

Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline, and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives was designed, synthesised, and evaluated in vitro against three ...
Jean Guillon, Anita Cohen, Clotilde Boudot, Alessandra Valle, Vittoria Milano, Rabindra Nath Das, Aurore Guédin, Stéphane Moreau, Luisa Ronga, Solène Savrimoutou, Maxime Demourgues, Elodie Reviriego, Sandra Rubio, Sandie Ferriez, Patrice Agnamey, Cécile Pauc, Serge Moukha, Pascale Dozolme, Sophie Da Nascimento, Pierre Laumaillé, Anne Bouchut, Nadine Azas, Jean-Louis Mergny, Catherine Mullié, Pascal Sonnet, Bertrand Courtioux   +25 more
doaj   +1 more source