Results 41 to 50 of about 32,780 (234)

Resolving Trypanosoma brucei Flagellar Structure by Cryo-Electron Tomography [PDF]

E3S Web of Conferences, 2019
Trypanosoma brucei is a unicellular eukaryote that can cause human African trypanosomiasis, which has continued to evolve and spread. The key feature of these parasites is that they have a flagellum consists of a typical 9 + 2 axoneme and a lattice-like ...
Dai Jennifer
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TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei [PDF]

, 2014
The procyclic form of Trypanosoma brucei expresses procyclin surface glycoproteins with unusual glycosylphosphatidylinositol-anchor side chain structures that contain branched N-acetyllactosamine and lacto-N-biose units.
Hashida, Kazunori, Ferguson, Michael A.J., Nakanishi, Masayuki, Karasudani, Moe, Nomoto, Hiroshi, Hino, Mami, Ferguson, Michael A. J; id_orcid, Shiraishi, Takahiro   +7 more
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Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline, and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives was designed, synthesised, and evaluated in vitro against three ...
Jean Guillon, Anita Cohen, Clotilde Boudot, Alessandra Valle, Vittoria Milano, Rabindra Nath Das, Aurore Guédin, Stéphane Moreau, Luisa Ronga, Solène Savrimoutou, Maxime Demourgues, Elodie Reviriego, Sandra Rubio, Sandie Ferriez, Patrice Agnamey, Cécile Pauc, Serge Moukha, Pascale Dozolme, Sophie Da Nascimento, Pierre Laumaillé, Anne Bouchut, Nadine Azas, Jean-Louis Mergny, Catherine Mullié, Pascal Sonnet, Bertrand Courtioux   +25 more
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Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei [PDF]

, 2014
Trypanosoma brucei expresses a diverse repertoire of N-glycans, ranging from oligomannose and paucimannose structures to exceptionally large complex N-glycans.
Damerow, Manuela, Ferguson, Michael A. J.; id_orcid, Güther, M. Lucia S., Wu, Di, Mehlert, Angela, Rodrigues, Joao A.   +5 more
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Development of a camelid single-domain antibody-based antigen detection assay for the pan-specific diagnosis of active human and animal Trypanosoma brucei infections

Journal of Clinical Microbiology
Trypanosoma brucei infections cause African trypanosomiasis, also known as sleeping sickness in humans and nagana in animals, presenting a significant global health and economic burden, especially in sub-Saharan Africa.
Zeng Li, Bo-kyung Jin, Emily Estefania Timaury Moreno, Andrés Álvarez-Rodríguez, Jo A. Van Ginderachter, Magdalena Radwanska, Yann G. -J. Sterckx, Benoit Stijlemans, Stefan Magez   +8 more
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Analytical purification of a 60-kDa target protein of artemisinin detected in Trypanosoma brucei brucei

Data in Brief, 2015
Here we describe the isolation and purity determination of Trypanosoma brucei (T. b.) brucei candidate target proteins of artemisinin. The candidate target proteins were detected and purified from their biological source (T. b.
Benetode Konziase
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Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by Trypanolytic factor 1 [PDF]

, 2011
<p><b>Background:</b> The three sub-species of <i>Trypanosoma brucei</i> are important pathogens of sub-Saharan Africa. <i>T. b.
C. Michael R. Turner, Hajduk, Stephen L., Capewell, P., Hajduk Stephen L., Stephen L Hajduk, C Michael R Turner, Annette MacLeod, Stephen L. Hajduk, Turner, C.M.R., Berriman, Matthew, MacLeod Annette, Paul Capewell, Nicola J Veitch, MacLeod, A., MacLeod, Annette, Hajduk, S.L., Veitch, Nicola J., Nicola J. Veitch, Berriman, M., Jayne Raper, Raper, J., Turner C. Michael R., Raper, Jayne, Veitch, N.J., Matthew Berriman, Capewell, Paul, Raper Jayne, Capewell Paul, R. Turner, C. Michael, Veitch Nicola J., Berriman Matthew   +30 more
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Réponse du poulet nigérian local ( Gallus domesticus) aux trypanosomes

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1988
La réponse du poulet nigérian local aux souches de Trypanosoma brucei 8/18 et T. vivax Y58 a été recherchée. Le poulet local utilisé dans cette étude était sensible à T. brucei mais réfractaire à T. vivax (Y58) (une souche adaptée aux rongeurs).
O.A. Dina, R.O.A. Arowolo
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Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol [PDF]

, 2013
The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. The role of transporters as determinants of drug susceptibility is
Kaiser Marcel, Brun Reto, de Koning Harry P., Patient Pati Pyana, Philippe Büscher, Büscher Philippe, Marcel Kaiser (41510), Mäser, Pascal, Ludin Philipp, Kaiser, Marcel, Büscher, Philippe, Harry P. de Koning (370318), Philipp Ludin, Pascal Mäser (87895), Philipp Ludin (228110), Horn David, Wenzler, Tanja, Tanja Wenzler, Patient Pati Pyana (224071), Graf, Fabrice E., David Horn, Ludin, Philipp, Marcel Kaiser, Pascal Mäser, Pyana, Patient Pati, Horn, David, David Horn (24969), Fabrice E. Graf (469055), Pyana Patient Pati, Philippe Büscher (150731), Fabrice E Graf, Wenzler Tanja, Tanja Wenzler (320253), Horn, David; id_orcid, Brun, Reto, Harry P de Koning, Graf Fabrice E., de Koning, Harry P., Reto Brun, Mäser Pascal, Reto Brun (41511)   +40 more
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In vitro Anti-trypanosomal Activity of Ethanolic and n-Hexane Extracts of Hymenocardia acida Stem Bark against Trypanosoma brucei brucei and Trypanosoma congolense

UMYU Journal of Microbiology Research
The development of resistance by trypanosomes to existing trypanocidal drugs necessitates the need to search for safer and more effective alternative drugs with a broad spectrum of activity.
Lawal, S. M., Inabo, H. I., Ella, E. E., Okubanjo, O. O.   +3 more
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