Results 61 to 70 of about 32,780 (234)

Global quantitative SILAC phosphoproteomics reveals differential phosphorylation is widespread between the procyclic and bloodstream form lifecycle stages of Trypanosoma brucei [PDF]

, 2013
We report a global quantitative phosphoproteomic study of bloodstream and procyclic form Trypanosoma brucei using SILAC labeling of each lifecycle stage.
Michael A. J. Ferguson, Urbaniak, Michael, David M. A. Martin, Ferguson, Michael A. J., Ferguson, Michael A. J.; id_orcid, Michael D. Urbaniak, Urbaniak, Michael D., Martin, David M. A.; id_orcid, Martin, David M. A.   +8 more
core   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Structure of thioredoxin from Trypanosoma brucei brucei

FEBS Letters, 2003
The three‐dimensional structure of thioredoxin from Trypanosoma brucei brucei has been determined at 1.4 Å resolution. The overall structure is more similar to that of human thioredoxin than to any other thioredoxin structure. The most striking difference to other thioredoxins is the absence of a buried carboxylate behind the active site cysteines ...
Friemann, Rosmarie, Schmidt, Heide, Ramaswamy, S., Forstner, Michael, Krauth-Siegel, R.Luise, Eklund, Hans   +5 more
openaire   +2 more sources

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs [PDF]

, 2013
Objectives: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T.
Lee, Rebecca S, Burchmore, Richard J S, Natto, Manal J, Eze, Anthonius, Graf, Fabrice, Burchmore, Richard JS, Lee, Rebecca, de Koning, Harry, Glover, Lucy, Mäser, Pascal, Teka, Ibrahim, Barrett, Michael P., Munday, Jane C., Teka, Ibrahim A., De Koning, Harry P., Eze, Anthonius A, Graf, Fabrice E., De Koning, Harry P, Ludin, Philipp, McDonald, Jennifer, MacLeod, Annette, Turner, C Michael R., Munday, Jane C, Natto, Manal J., Lee, Rebecca S., Tait, Andy, Horn, David, Baker, Nicola, Munday, Jane, Turner, C Michael R, Aguinaga Andres, David, Barrett, Michael P, Andrés, David Aguinaga, Burchmore, Richard, Clucas, Caroline, Graf, Fabrice E, Horn, David; id_orcid, Burchmore, Richard J. S., Teka, Ibrahim A, Eze, Anthonius A., Natto, Manal, Turner, C. Michael R., Barrett, Michael   +42 more
core   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, EarlyView.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Population genetics of trypanosoma brucei rhodesiense: clonality and diversity within and between foci [PDF]

, 2013
African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development.
C. Michael R. Turner, Cooper, Anneli, Duffy, Craig W, Duffy, C.W., C Michael R Turner, Annette MacLeod, Cooper Anneli, MacLeod Annette, Lorna MacLean (126077), Lindsay Sweeney, MacLeod, A., MacLeod, Annette, Craig W. Duffy, Morrison, Liam; id_orcid, Tait, Andy, Morrison, L.J., Craig W Duffy, Sternberg, Jeremy, Sweeney, Lindsay, Morrison Liam J., Cooper, A., Sternberg, J., Tait, A., Duffy, Craig W., Jeremy Sternberg, Andy Tait, Lindsay Sweeney (51760), MacLean Lorna, Tait Andy, Duffy, Craig, Liam J Morrison, Tait, Andrew, Liam J. Morrison, Andy Tait (12786), Turner, C.M.R., Sweeney Lindsay, Liam J. Morrison (211421), Duffy Craig W., C. Michael R. Turner (12785), Turner, C M, MacLean, L., Craig W. Duffy (429693), Anneli Cooper (51759), Anneli Cooper, Turner, C Michael R, Morrison, Liam J, Jeremy Sternberg (485210), Sweeney, L., Annette MacLeod (12779), Sternberg Jeremy, Lorna MacLean, Turner C. Michael R., MacLean, Lorna, Morrison, Liam J., Turner, C. Michael R.   +54 more
core   +1 more source

Comparative evaluation of the attractiveness of new polyethylene screens versus West African tiny target for the control of tsetse flies

Medical and Veterinary Entomology, EarlyView.
The material has no significant difference in captures (non‐shiny cotton‐polyester screens vs. the shiny polyethylene screens), but the vertical screen attracted significantly more G. tachinoides for each type of material. Full white horizontal screen was significantly lower than the reference WATT.
Ernest Wendemanegde Salou, Geoffrey Gimonneau, Wilfrid Yoni, Issiaka Barry, Viral Shah, Marc Desquesnes   +5 more
wiley   +1 more source

The developmental cell biology of Trypanosoma brucei [PDF]

, 2005
Trypanosoma brucei provides an excellent system for studies of many aspects of cell biology, including cell structure and morphology, organelle positioning, cell division and protein trafficking. However, the trypanosome has a complex life cycle in which
Matthews, Keith R; id_orcid, Keith R. Matthews   +1 more
core   +1 more source

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman, Janine Aucamp, Helena D. Janse van Rensburg, Christina Kannigadu, Rotondwa Mphephu, Andrew J. Swarts, Keisuke Suganuma, David D. N'Da   +7 more
wiley   +1 more source