Results 71 to 80 of about 75,630 (213)

Genetic exchange in Trypanosoma brucei: evidence for mating prior to metacyclic stage development [PDF]

, 2005
It is well established that genetic exchange occurs between Trypanosoma brucei parasites when two stocks are used to infect tsetse flies under laboratory conditions and a number of such crosses have been undertaken.
Turner, C.M.R., Tait, A., Tweedie, A., Masiga, D., MacLeod, A.   +4 more
core   +1 more source

A bacterial protein inhibitor of dUTPase disrupts zebrafish embryogenesis through a conserved active‐site mechanism

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Deoxyuridine triphosphatase (dUTPase) is essential for DNA replication fidelity and embryonic development in metazoa, yet whether a protein inhibitor can acutely disrupt dUTPase function in a living vertebrate has not been tested. The Staphylococcus aureus Stl protein inhibits diverse dUTPases in vitro, but its efficacy in a eukaryotic ...
Viktória Perey‐Simon, Zoé Sára Tóth, Dániel Dombovári, Latifa Kazzazy, Máté Varga, Beáta G. Vértessy, Gergely Nándor Nagy, Kinga Nyíri   +7 more
wiley   +1 more source

Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by Trypanolytic factor 1 [PDF]

, 2011
<p><b>Background:</b> The three sub-species of <i>Trypanosoma brucei</i> are important pathogens of sub-Saharan Africa. <i>T. b.
C. Michael R. Turner, Hajduk, Stephen L., Capewell, P., Hajduk Stephen L., Stephen L Hajduk, C Michael R Turner, Annette MacLeod, Stephen L. Hajduk, Turner, C.M.R., Berriman, Matthew, MacLeod Annette, Paul Capewell, Nicola J Veitch, MacLeod, A., MacLeod, Annette, Hajduk, S.L., Veitch, Nicola J., Nicola J. Veitch, Berriman, M., Jayne Raper, Raper, J., Turner C. Michael R., Raper, Jayne, Veitch, N.J., Matthew Berriman, Capewell, Paul, Raper Jayne, Capewell Paul, R. Turner, C. Michael, Veitch Nicola J., Berriman Matthew   +30 more
core   +1 more source

Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria

Parasites & Vectors, 2019
Background Animal trypanosomosis is endemic in Nigeria, while the human disease caused by Trypanosoma brucei gambiense is rarely reported nowadays after efforts to bring it under control in the 20th century.
Paschal Ugochukwu Umeakuana, Wendy Gibson, Romanus Chukwuduruo Ezeokonkwo, Boniface Maduka Anene   +3 more
doaj   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1686-1701, October 2026.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several anti-trypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
Schnaufer, Achim; id_orcid, Gould, Matthew K   +1 more
core   +1 more source

Coumarin‐Benzimidazole Hybrids as Multitarget Scaffolds for Antileishmanial Drug Discovery

ChemistrySelect, Volume 11, Issue 38, 13 October 2026.
Coumarin‐benzimidazole hybrids emerge as promising antileishmanial agents through virtual screening against essential Leishmania enzymes, Cathepsin B (CatB), and N‐myristoyltransferase (NMT). Molecular docking and dynamics simulations reveal highly stable target interactions that surpass the reference drug miltefosine (MTF).
Fernanda Melo Jucá, Damião Sampaio de Sousa, Caio Henrique Alexandre Roberto, Márcia Machado Marinho, Emmanuel Silva Marinho   +4 more
wiley   +1 more source

Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty. [PDF]

, 2015
Two key biological features distinguish Trypanosoma evansi from the T. brucei group: independence from the tsetse fly as obligatory vector, and independence from the need for functional mitochondrial DNA (kinetoplast or kDNA).
Hideo Imamura (62469), Dhileep Sivam, Myler, Peter, Ivens Alasdair, McDermott, Suzanne M., Sivam Dhileep, Ramasamy, Gowthaman, Lukeš Julius, Kořený Luděk, Schnaufer, Achim, Michael Lewis (339161), Chris Merritt (682366), Severine Monnerat (3278655), De-Hua Lai, Brown, Rob, Claire Gendrin, Balmer Oliver, Merritt, Chris, Andrew Jackson, Monnerat Severine, Michael Lewis, Lun, Zhao Rong, Hideo Imamura, Wonjong Moon, Stuart, Ken, Isabelle Phan, Marc Desquesnes, Jackson, Andrew, Myler Peter, Balmer, Olivier, Alasdair Ivens, Gowthaman Ramasamy (19191), Schnaufer, Achim; id_orcid, McDermott Suzanne M., Carnes Jason, Ivens, Alasdair, Peter Myler (592207), Phan, Isabelle, Lukeš, Julius, Lun, Zhao-Rong, Lai, De Hua, Jason Carnes, Imamura Hideo, Lai De-Hua, Balmer, Oliver, Alasdair Ivens (33327), Gendrin, Claire, Lai, De-Hua, Gendrin Claire, Desquesnes, Marc, Julius Lukeš, Anupama, Atashi, Cestari, Igor, Zhao-Rong Lun, Chris Merritt, Cestari Igor, Suzanne M. McDermott (436260), Ken Stuart, Isabelle Phan (5674), Brown Rob, Peter Myler, Jackson Andrew, Suzanne M McDermott, Igor Cestari (251742), Hertz-Fowler Christiane, Rob Brown (682364), Monnerat, Severine, Julius Lukeš (122896), Lewis, Michael, Imamura, Hideo, McDermott, Suzanne M, Annette MacLeod, Stuart Ken, MacLeod Annette, Severine Monnerat, MacLeod, Annette, Anupama Atashi, Luděk Kořený (240382), Gowthaman Ramasamy, Achim Schnaufer (243262), Desquesnes Marc, Zhao-Rong Lun (104756), Ramasamy Gowthaman, Achim Schnaufer, Merritt Chris, Sivam, Dhileep, Andrew Jackson (376958), Luděk Kořený, Dhileep Sivam (682368), Hertz-Fowler, Christiane, Moon, Wonjong, Wonjong Moon (682367), Oliver Balmer, Moon Wonjong, Lewis Michael, Jason Carnes (47297), Atashi Anupama (682363), Lun Zhao-Rong, Phan Isabelle, Ken Stuart (682369), Igor Cestari, Oliver Balmer (151993), Claire Gendrin (173845), Kořený, Luděk, Atashi Anupama, Carnes, Jason, Annette MacLeod (12779), Christiane Hertz-Fowler, Marc Desquesnes (457900), Christiane Hertz-Fowler (243178), Rob Brown, Schnaufer Achim, De-Hua Lai (682365), J Carnes   +113 more
core   +1 more source

Integrative delimitation of loricate euglenids (Euglenophyta) based on molecular and morphological evidence: Strombomonas, Trachelomonas, and Parastrombomonas gen. nov.

TAXON, Volume 75, Issue 5, October 2026.
Abstract DNA sequences of loricate euglenids (genera Strombomonas and Trachelomonas) were analyzed in conjunction with detailed examinations of lorica and monad morphology. Phylogenetic analyses were conducted using 342 new sequences representing three molecular markers (149 nSSU, 102 nLSU, 91 cpSSU rDNA).
Alicja Fells, Maja Łukomska‐Kowalczyk, Rafał Milanowski, Bożena Zakryś   +3 more
wiley   +1 more source

Identification of novel components of Trypanosoma brucei editosomes [PDF]

, 2003
The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei.
Schnaufer, Achim; id_orcid, Wang, Bingbing, Salavati, Reza, Stuart, Kenneth, Carmean, Nicole, Panigrahi, Aswini K, Ernst, Nancy L   +6 more
core   +1 more source