Results 81 to 90 of about 32,780 (234)

In vitro antitrypanosomal potential of chloroform leaf extract of Punica granatum L. on Trypanosoma brucei brucei and Trypanosoma evansi

Microbiology Research, 2017
The plant Pomegranate (Punica granatum Linn.) selected for this study is native to the region of Eurasia. The objective of this study was to evaluate the antitrypanosomal potential of the plant against Trypanosoma brucei brucei (T.b.
Muhammad Muhsin Fathuddin, Helen Ileigo Inabo   +1 more
doaj   +1 more source

Extracellular Vesicles of Giardia duodenalis: Unravelling Their Virulence Factors and Potential to Induce Protection Against Experimental Giardiasis

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Extracellular vesicles (EVs) are key mediators of intercellular communication, enabling trans‐kingdom exchange of proteins, nucleic acids, lipids, and metabolites. In Giardia duodenalis, EVs contribute to parasite survival, host–pathogen interactions, and immune modulation.
Corral‐Ruiz Gerardo, Argüello‐García Raúl, Ortiz‐Lozano Dalia, Salazar‐Villatoro Lizbeth, Pech‐Santiago Edar Onam, Espinosa‐Cantellano Martha, Hernández‐Cueto Daniel, Silva‐Olivares D. Angélica, Betanzos Abigail, Ortega‐Pierres M. Guadalupe   +9 more
wiley   +1 more source

Localization of serum resistance-associated protein in Trypanosoma brucei rhodesiense and transgenic Trypanosoma brucei brucei.

Cellular microbiology, 2015
Peer ...
Bart, Jean-Mathieu, Cordon-Obras, Carlos, Vidal, Isabel, Reed, Jennifer, Perez-Pastrana, Esperanza, Cuevas, Laureano, Field, Mark C., Carrington, Mark, Navarro, Miguel   +8 more
openaire   +5 more sources

The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei [PDF]

, 2014
Funded by Wellcome Trust: Senior Research Fellowship, Grant Number: 067441 and Wellcome Trust, Grant Numbers: 082596, 093228.Lipid metabolism in Trypanosoma brucei, the causative agent of African sleeping sickness, differs from its human host in several ...
Lilley, Alison C., Smith, Terry K., Smith, Terry K, Young, Simon, Stark, Michael J. R., Lilley, Alison Catherine, Major, Louise Laura, Major, Louise   +7 more
core   +1 more source

MICOS and MIMAS, multifunctional assemblies linking mitochondrial biogenesis, architecture, and function

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Mitochondrial cristae architecture is central for optimal oxidative phosphorylation and a healthy mitochondrial physiology. The intricate architecture of the inner mitochondrial membrane relies on protein complexes that compartmentalize the membrane by imposing membrane curvature, forming membrane contact sites or membrane subdomains ...
Patrick Horten, Kuo Song, Nikolaus Pfanner, Heike Rampelt   +3 more
wiley   +1 more source

Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria

Parasites & Vectors, 2019
Background Animal trypanosomosis is endemic in Nigeria, while the human disease caused by Trypanosoma brucei gambiense is rarely reported nowadays after efforts to bring it under control in the 20th century.
Paschal Ugochukwu Umeakuana, Wendy Gibson, Romanus Chukwuduruo Ezeokonkwo, Boniface Maduka Anene   +3 more
doaj   +1 more source

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Caroline Rodrigues Chaves dos Reis, Hellen Valério Chaves Moura de Souza, Lidia Corrêa Parra, Guilber Valério Chaves Moura de Souza, Bruna Costa Zorzanelli, Nubia Boechat, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes   +7 more
wiley   +1 more source

Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in Tsetse in Serengeti, Tanzania [PDF]

, 2012
Background: Measuring the prevalence of transmissible Trypanosoma brucei rhodesiense in tsetse populations is essential for understanding transmission dynamics, assessing human disease risk and monitoring spatio-temporal trends and the impact of control ...
Auty, Harriet K., Malele Imna, Sue Welburn, Imna Malele, Picozzi, K., Torr, Steve J., Welburn, S., Malele, I., Auty Harriet K., Cleaveland, S., Auty, Harriet K, Picozzi, Kim, Harriet K Auty, Welburn, Sue, Welburn, Susan, Torr Steve J., Malele, Imna, Steve J Torr, Welburn Sue, Cleaveland, Sarah, Sarah Cleaveland, Auty, H.K., Torr, Steve J, Kim Picozzi, Picozzi Kim, Torr, S.J., Cleaveland Sarah   +26 more
core   +1 more source

Synergistische Entwicklungsstrategien von Inhibitoren gegen humane UDP‐Galactose‐4‐Epimerase

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
Die Epimerase GalE ist essenziell für die Biosynthese von krebsrelevanten O‐GalNAc Glykanen. Wir verwenden orthogonales, strukturbasiertes Screening niedermolekularer Fragmente an, um kovalente und nichtkovalente Inhibitoren gegen GalE mit nicht mehr als 22 optimierten Verbindungen zu erhalten.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species [PDF]

, 2012
Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis ("sleeping sickness") across sub-Saharan Africa and ...
Browne, H., Jackson, Andrew P., Marcello, Lucio, Jackson, A.P., Jackson, A. P., Quail, M. A., Ginger, M. L., Marcello, L., Quail, M.A., Berriman, Matthew, Jackson, Andrew P, Berry, Andrew, Field, M. C., Aslett, Martin, Sanders, Mandy J., McQuillan, J., Barry, J. David, Field, Mark C., Allinson, Harriet C., Browne, Hilary, Hauser, H., Aslett, M., Barry, J.D., Burton, Peter, Allison, Harriet C., Ginger, Michael L., Gilderthorp, Ruth, Berry, A., van Tonder, Andries, Allison, H.C., McQuillan, Jacqueline, Burton, P., Ginger, M.L., Corton, Nicola, Gilderthorp, R., Hertz-Fowler, Christiane, Field, M.C., Field, MarkC., Corton, N., Quail, Michael A., Gamble, John, Brown, R., Otto, Thomas D., Otto, T. D., Barry, J. D., Gamble, J., Hauser, Heidi, Hertz-Fowler, C., Brown, Robert, van Tonder, A., Berriman, M., Ginger, Michael, Vavrova-Anderson, Jana, Vavrova-Anderson, J., Sanders, M.J., Allison, H. C., Hertz-Fowler, Christine, Otto, T.D., Sanders, M. J.   +58 more
core   +1 more source