Results 101 to 110 of about 32,780 (234)

Mathematical modelling of polyamine metabolism in bloodstream-form trypanosoma brucei: An application to drug target identification [PDF]

, 2013
© 2013 Gu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Desmond J Higham, Xu Gu (276054), Gilbert, D, Gu, X, David Reid (276055), Desmond J. Higham (261142), Reid, D, David Gilbert, David Reid, Gilbert David, Gu Xu, David Gilbert (276056), Reid David, Desmond J. Higham, Xu Gu, Higham, DJ, Higham Desmond J.   +16 more
core   +1 more source

In Vitro Antitrypanosomal and Antibacterial Activity of Aqueous, Hydroethanolic and Ethanolic Extracts of Rumex obtusifolius L. Leaf and Root

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 5, May 2026.
ABSTRACT Plant extracts are an important raw material for the development of new drugs. Rumex obtusifolius L., popularly known as ‘bitter dock’, has significant pharmacological properties. This study evaluated the in vitro antitrypanosomal activity of aqueous, hydroethanolic and ethanolic extracts from the leaf and roots of R. obtusifolius L.
Gabriela K. Borges, Gabriella B. Das Neves, Letícia Reichardt, Ubirajara Maciel da Costa, Luiz C. Miletti, Amanda L. Bastos‐Pereira   +5 more
wiley   +1 more source

Allelic segregation and independent assortment in T. brucei crosses: proof that the genetic system is Mendelian and involves meiosis [PDF]

, 2005
The genetic system on Trypanosoma brucei has been analysed by generating large numbers of independent progeny clones from two crosses, one between two cloned isolates of Trypanosoma brucei brucei and one between cloned isolates of T. b.
Turner, CMR, MacLeod, A, Taylor, S, Taylor, S., McLellan, S, Cooper, A., Sweeney, L., Turner, C.M.R., Cooper, A, Tweedie, A., Tait, A., Tait, A, MacLeod, A., Sweeney, L, McLellan, S., Tweedie, A   +15 more
core   +1 more source

Trypanosoma brucei infection protects mice against malaria.

PLoS Pathogens, 2019
Sleeping sickness and malaria are parasitic diseases with overlapping geographical distributions in sub-Saharan Africa. We hypothesized that the immune response elicited by an infection with Trypanosoma brucei, the etiological agent of sleeping sickness,
Margarida Sanches-Vaz, Adriana Temporão, Rafael Luis, Helena Nunes-Cabaço, António M Mendes, Sarah Goellner, Tânia Carvalho, Luisa M Figueiredo, Miguel Prudêncio   +8 more
doaj   +1 more source

Serum lipoprotein and Trypanosoma brucei brucei interactions in vitro

Molecular and Biochemical Parasitology, 1989
Trypanosoma brucei brucei IL3201 and IL3202, which are dependent on serum high or low-density lipoproteins to multiply under axenic culture conditions, acquired lipoprotein-associated 3H-lipids without binding, accumulating or degrading apolipoproteins. Uptake by the T. b.
Vandeweerd, V., Black, Samuel J.
openaire   +3 more sources

Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors : toward the development of novel therapies for African sleeping sickness [PDF]

, 2010
Trypanosoma brucei, the causative agent of human African trypanosomiasis, affects tens of thousands of sub-Saharan Africans. As current therapeutics are inadequate due to toxic side effects, drug resistance, and limited effectiveness, novel therapies are
Michael A. J. Ferguson, Durrant, Jacob D., Ferguson, Michael A. J., Jacob D. Durrant, Ferguson, Michael A. J.; id_orcid, Michael D. Urbaniak, McCammon, J. Andrew, Urbaniak, Michael D., J. Andrew McCammon   +8 more
core   +1 more source

Regulation of Trypanosoma brucei Total and Polysomal mRNA during Development within Its Mammalian Host [PDF]

, 2013
The gene expression of Trypanosoma brucei has been examined extensively in the blood of mammalian hosts and in forms found in the midgut of its arthropod vector, the tsetse fly.
Ivens, A, Pegine Walrad (267013), Capewell, P, Ivens, Alasdair, Terry K Smith, Keith R Matthews, Macgregor, Paula, Matthews, Keith R; id_orcid, Bringaud, F, Bringaud, Frederic, Smith, Terry K., Paul Capewell (137761), Katelyn Fenn (22199), Paula Macgregor, Smith, T, Fenn, K, Paul Capewell, Stephanie Monk, MacGregor, P, Alasdair Ivens (33327), Katelyn Fenn, Keith R. Matthews (199001), Matthews, K, Matthews, Keith R., Frederic Bringaud, Walrad, Pegine, Monk, S, Terry K. Smith (112550), Walrad, P, Stephanie Monk (427018), Matthews, Keith R, Keith R. Matthews, Frederic Bringaud (5655364), Smith, Terry K, Monk, Stephanie, Pegine Walrad, Fenn, Katelyn, Capewell, Paul, Alasdair Ivens, Terry K. Smith, Paula MacGregor (198985)   +40 more
core   +1 more source

Autophagic-related cell death of Trypanosoma brucei induced by bacteriocin AS-48

International Journal for Parasitology: Drugs and Drug Resistance, 2018
The parasitic protozoan Trypanosoma brucei is the causative agent of human African trypanosomiasis (sleeping sickness) and nagana. Current drug therapies have limited efficacy, high toxicity and/or are continually hampered by the appearance of resistance.
Marta Martínez-García, Jean-Mathieu Bart, Jenny Campos-Salinas, Eva Valdivia, Manuel Martínez-Bueno, Elena González-Rey, Miguel Navarro, Mercedes Maqueda, Rubén Cebrián, José M. Pérez-Victoria   +9 more
doaj   +1 more source

Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei : the ethanolamine and choline kinases [PDF]

, 2008
Note related output below contains correction of this paper.Ethanolamine and choline are major components of the trypanosome membrane phospholipids, in the form of GPEtn (glycero-phosphoethanolamine) and GPCho (glycerophosphocholine).
Smith, Terry K., Gibellini, Federica, Smith, Terry K, Hunter, William N., Gibellini, F., Hunter, W. N., Hunter, William N   +6 more
core   +1 more source

Performance of diagnostic tests for Trypanosoma brucei brucei in experimentally infected pigs. [PDF]

PLoS Negl Trop Dis, 2023
Ilboudo K, Boulangé A, Hounyèmè RE, Gimonneau G, Kaboré J, Belem AGM, Desquesnes M, Lejon V, Koffi M, Jamonneau V, Thévenon S.   +10 more
europepmc   +1 more source