Results 91 to 100 of about 32,780 (234)

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, Volume 65, Issue 22, 25 May 2026.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism [PDF]

, 2012
Kinetic models of metabolism require detailed knowledge of kinetic parameters. However, due to measurement errors or lack of data this knowledge is often uncertain.
Achcar, Fiona,, Kerkhoven Eduard J., Barrett, M.P., Breitling, Rainer, Breitling, R., Fiona Achcar, Breitling, Rainer,, Bakker, Barbara M.; id_orcid, Achcar, Fiona, Achcar, F., Eduard J. Kerkhoven (187101), Fiona Achcar (187100), Breitling Rainer, Bakker Barbara M., SilicoTryp Consortium, Barrett, Michael P., Rainer Breitling (4371), Michael P Barrett, Bakker, B.M., Barbara M. Bakker (102159), Barrett, Michael P.,, Bakker, Barbara M., Barbara M Bakker, Kerkhoven, Eduard J, Matthews, Keith; id_orcid, Kerkhoven, Eduard J.,, Bakker, Barbara M, Rainer Breitling, Barrett, Michael P, Kerkhoven, E.J., ?, ?, Eduard J Kerkhoven, Achcar Fiona, Barrett Michael P., Bakker, Barbara M.,, Kerkhoven, Eduard J., Michael P. Barrett (167748)   +36 more
core   +1 more source

Résistance médicamenteuse d'isolats récents de Trypanosoma brucei et Trypanosoma congolense

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1988
Des études ont été menées sur des souris pour déterminer la sensibilité aux médicaments d’isolats récents de Trypanosoma brucei et Trypanosoma congolense. Chacune des onze souches de T. congolense et des cinq souches de T. brucei, toutes isolées sur des
R.A. Joshua
doaj   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Identification of ORC1/CDC6-interacting factors in trypanosoma brucei reveals critical features of origin recognition complex architecture [PDF]

, 2012
DNA Replication initiates by formation of a pre-replication complex on sequences termed origins. In eukaryotes, the pre-replication complex is composed of the Origin Recognition Complex (ORC), Cdc6 and the MCM replicative helicase in conjunction with ...
Tiengwe Calvin, J. David Barry, Marcello, Lucio, Farr, H., Burchmore, R., Lucio Marcello (178735), Calvin Tiengwe (178730), Marcello, L., Richard McCulloch (12918), McCulloch Richard, Barry, J. David, Stephen D. Bell, Gadelha, Catarina, Gadelha, C., McCulloch, R, Bell Stephen D., Stephen D. Bell (22094), Tiengwe, Calvin, Barry, J.D., McCulloch, R., Barry, J David, Lucio Marcello, J David Barry, Bell, S.D., McCulloch, Richard, Helen Farr, Tiengwe, C., Richard Burchmore, Barry J. David, Gadelha Catarina, Burchmore, R, Farr Helen, Farr, Helen, Catarina Gadelha (178740), Gadelha, C, Helen Farr (81310), Bell, Stephen D, Richard Burchmore (178746), Tiengwe, C, Marcello, L, J. David Barry (60385), Bell, Stephen D., Barry, JD, Burchmore, Richard, Farr, H, Stephen D Bell, Catarina Gadelha, Richard McCulloch, Burchmore Richard, Calvin Tiengwe, Bell, Stephen, Marcello Lucio   +51 more
core   +1 more source

Trypanosoma brucei

Trends in Parasitology, 2020
Gabriela, Romero-Meza, Monica R, Mugnier
openaire   +4 more sources

Trypanosoma Infection Favors Brucella Elimination via IL-12/IFNγ-Dependent Pathways

Frontiers in Immunology, 2017
This study develops an original co-infection model in mice using Brucella melitensis, the most frequent cause of human brucellosis, and Trypanosoma brucei, the agent of African trypanosomiasis. Although the immunosuppressive effects of T.
Arnaud Machelart, Margaux Van Vyve, Georges Potemberg, Aurore Demars, Carl De Trez, Hermann Giresse Tima, Gilles Vanwalleghem, Marta Romano, Carine Truyens, Jean-Jacques Letesson, Eric Muraille, Eric Muraille   +11 more
doaj   +1 more source

Rhenium Complexes as Antimicrobial Agents

Helvetica Chimica Acta, Volume 109, Issue 5, May 2026.
Rhenium complexes are stepping into the fight against superbugs. Our new review explores how these metallic complexes could inspire the next generation of antimicrobial therapies. ABSTRACT The escalating crisis of antimicrobial resistance (AMR) necessitates the exploration of unconventional therapeutic scaffolds.
Fabio Zobi, Gozde Demirci, Marija Rasic
wiley   +1 more source

Trypanosoma brucei brucei: Expression of drug resistance in vitro

Experimental Parasitology, 1989
The susceptibility of five Trypanosoma brucei brucei stocks to diminazene aceturate (Berenil) and isometamidium chloride (Samorin) was determined in vivo and in vitro. Two stocks were resistant in mice to both drugs. Differences in drug-induced growth inhibition occurred between drug-resistant and drug-sensitive stocks when trypanosome bloodstream ...
Kaminsky, R., Chuma, Francis, Zweygarth, E.   +2 more
openaire   +3 more sources

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro

, 2014
It is well known that several anti-trypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
Schnaufer, Achim; id_orcid, Gould, Matthew K   +1 more
core   +1 more source