The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System
Biomolecules, 2022 The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites.
Sajad Rashidi +5 more
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Genome-Wide Identification of Novel miRNAs and Infection-Related Proteins in Leishmania major via Comparative Analysis of the Protozoa, Vectors, and Mammalian Hosts [PDF]
PathogensLeishmania major is a unicellular protozoan that causes cutaneous leishmaniasis in mammals and is mainly transmitted by the sand fly Phlebotomus papatasi.
Tianyi Liu +4 more
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Hsp90 and associates shaping parasite biology [PDF]
mSphereHsp90 is considered to be the master regulator of chaperone activity within the cellular context. In addition to aiding client maturation and maintaining protein homeostasis, Hsp90 serves various non-canonical functions in model eukaryotes: ranging from ...
Abhilasha Gahlawat +2 more
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Down the membrane hole: Ion channels in protozoan parasites
PLoS Pathogens, 2022 Parasitic diseases caused by protozoans are highly prevalent around the world, disproportionally affecting developing countries, where coinfection with other microorganisms is common.
Veronica Jimenez, Sebastian Mesones
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Zoonotic Malaria Risk in Serra Do Mar, Atlantic Forest, Brazil
Microorganisms, 2023 Here, the main goal is to assess natural infections of Plasmodium spp. in anophelines in a forest reserve from the same region where we previously found a surprisingly high rate (5.2%) of plasmodia infections (n = 25) in Kerteszia mosquitoes (N = 480) on
Marina E. O. Rangel +7 more
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Frontiers in Genetics, 2022 Small GTPases are the key to actin cytoskeleton signaling, which opens the lock of effector proteins to forward the signal downstream in several cellular pathways. Actin cytoskeleton assembly is associated with cell polarity, adhesion, movement and other
Preeti Umarao +2 more
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The ATP-binding cassette proteins of the deep-branching protozoan parasite Trichomonas vaginalis. [PDF]
PLoS Neglected Tropical Diseases, 2012 The ATP binding cassette (ABC) proteins are a family of membrane transporters and regulatory proteins responsible for diverse and critical cellular process in all organisms.
Christopher Kay +5 more
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A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes. [PDF]
PLoS Neglected Tropical Diseases, 2014 Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Brendan D Galvin +7 more
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Cysteine proteases in protozoan parasites. [PDF]
PLoS Neglected Tropical Diseases, 2018 Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites, including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or modulation of the host immune response, making them attractive ...
Jair L Siqueira-Neto +6 more
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Role of Host Small GTPases in Apicomplexan Parasite Infection
Microorganisms, 2022 The Apicomplexa are obligate intracellular parasites responsible for several important human diseases. These protozoan organisms have evolved several strategies to modify the host cell environment to create a favorable niche for their survival.
Silvio Paone, Anna Olivieri
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