Results 31 to 40 of about 42,476 (197)
Characterization of a novel association between two trypanosome-specific proteins and 5S rRNA. [PDF]
PLoS ONE, 2012 P34 and P37 are two previously identified RNA binding proteins in the flagellate protozoan Trypanosoma brucei. RNA interference studies have determined that the proteins are essential and are involved in ribosome biogenesis.
Martin Ciganda, Noreen Williams
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Frontiers in Pharmacology, 2015 Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl ...
Jane Claire Munday +3 more
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Frontiers in Immunology, 2020 Chagas disease, a zoonosis caused by the flagellate protozoan Trypanosoma cruzi, is a chronic and systemic parasitic infection that affects ~5–7 million people worldwide, mainly in Latin America. Chagas disease is an emerging public health problem due to
Renata Watanabe Costa +13 more
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Proximity-Dependent Biotinylation and Identification of Flagellar Proteins in Trypanosoma cruzi
mSphere, 2023 The flagellated kinetoplastid protozoan and causative agent of human Chagas disease, Trypanosoma cruzi, inhabits both invertebrate and mammalian hosts over the course of its complex life cycle. In these disparate environments, T.
Madalyn M. Won +2 more
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The EhCPADH112 complex of Entamoeba histolytica interacts with tight junction proteins occludin and claudin-1 to produce epithelial damage. [PDF]
PLoS ONE, 2013 Entamoeba histolytica, the protozoan responsible for human amoebiasis, causes between 30,000 and 100,000 deaths per year worldwide. Amoebiasis is characterized by intestinal epithelial damage provoking severe diarrhea.
Abigail Betanzos +6 more
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Structural Basis of Parasitic HSP90 ATPase Inhibition by Small Molecules
Pharmaceuticals, 2022 Protozoan parasites are responsible for several harmful and widespread human diseases that cause high morbidity and mortality. Currently available treatments have serious limitations due to poor efficiency, strong adverse effects, and high cost.
Giusy Tassone +2 more
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Role of Leukotrienes on Protozoan and Helminth Infections
Mediators of Inflammation, 2012 Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities.
Alexandre P. Rogerio, Fernanda F. Anibal
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The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins
Pathogens, 2017 Lipid rafts are liquid-ordered membrane microdomains that form by preferential association of 3-β-hydroxysterols, sphingolipids and raft-associated proteins often having acyl modifications.
Aabha I. Sharma +2 more
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Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva +8 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Synthetic biology has recently proven to be a valuable tool for enhancing agriculture even in the face of environmental and biological stresses. Understanding the challenges that militate synthetic biology will assist in ensuring safe, stable, and scalable crop production.
Ben Jesuorsemwen Enagbonma +6 more
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