A novel EF-hand calcium-binding protein in the flagellum of the protozoan Tritrichomonas suis. [PDF]
, 2001 The cloning and characterization of Ts-p41, an EF-hand calcium-binding protein of the protozoan parasite Tritrichomonas suis is described. A T. suis cDNA library was screened with monospecific antibodies affinity purified on an immunoreactive 41 kDa ...
Felleisen, R S +5 more
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Characterization of a novel association between two trypanosome-specific proteins and 5S rRNA. [PDF]
PLoS ONE, 2012 P34 and P37 are two previously identified RNA binding proteins in the flagellate protozoan Trypanosoma brucei. RNA interference studies have determined that the proteins are essential and are involved in ribosome biogenesis.
Martin Ciganda, Noreen Williams
doaj +1 more source
Sequence Analysis and Comparison of TCTP Proteins from Human Protozoan Parasites [PDF]
Acta Parasitologica, 2022 Abstract Purpose Translational controlled tumor protein (TCTP) is a functionally important protein in most eukaryotes because it participates in a wide variety of processes, the most representative being proliferation, differentiation, histamine release, cell death, protein synthesis and response to stress conditions. In
openaire +3 more sources
Proximity-Dependent Biotinylation and Identification of Flagellar Proteins in Trypanosoma cruzi
mSphere, 2023 The flagellated kinetoplastid protozoan and causative agent of human Chagas disease, Trypanosoma cruzi, inhabits both invertebrate and mammalian hosts over the course of its complex life cycle. In these disparate environments, T.
Madalyn M. Won +2 more
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ATPe Dynamics in Protozoan Parasites: Adapt or Perish [PDF]
, 2021 In most animals, transient increases of extracellular ATP (ATPe) are used for physiological signaling or as a danger signal in pathological conditions.
Leal Denis, María F. +7 more
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Frontiers in Pharmacology, 2015 Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl ...
Jane Claire Munday +3 more
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Structural Basis of Parasitic HSP90 ATPase Inhibition by Small Molecules
Pharmaceuticals, 2022 Protozoan parasites are responsible for several harmful and widespread human diseases that cause high morbidity and mortality. Currently available treatments have serious limitations due to poor efficiency, strong adverse effects, and high cost.
Giusy Tassone +2 more
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Frontiers in Immunology, 2020 Chagas disease, a zoonosis caused by the flagellate protozoan Trypanosoma cruzi, is a chronic and systemic parasitic infection that affects ~5–7 million people worldwide, mainly in Latin America. Chagas disease is an emerging public health problem due to
Renata Watanabe Costa +13 more
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The EhCPADH112 complex of Entamoeba histolytica interacts with tight junction proteins occludin and claudin-1 to produce epithelial damage. [PDF]
PLoS ONE, 2013 Entamoeba histolytica, the protozoan responsible for human amoebiasis, causes between 30,000 and 100,000 deaths per year worldwide. Amoebiasis is characterized by intestinal epithelial damage provoking severe diarrhea.
Abigail Betanzos +6 more
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The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence [PDF]
, 2015 There are no commercially available vaccines against human protozoan parasitic diseases, despite the success of vaccination-induced long-term protection against infectious diseases.
Sonal Henson +29 more
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