Results 61 to 70 of about 45,570 (245)

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity

, 2010
Toxoplasma gondii is an obligate intracellular parasite that enters cells by a process of active penetration. Host cell penetration and parasite motility are driven by a myosin motor complex consisting of four known proteins: TgMyoA, an unconventional ...
Carey, Kimberly L., Federica Catti, David M Warshaw, Nicholas J Westwood, Catti, Federica, Gary E Ward, Jacqueline M Leung, Kimberly L Carey, Leung, Jacqueline M., Warshaw, David M., Ballif, Bryan A., Heaslip, Aoife T., Bryan A Ballif, Westwood, Nicholas J., Ward, Gary E., Aoife T Heaslip   +15 more
core   +1 more source

Differential expression of immune defences is associated with specific host-parasite interactions in insects [PDF]

, 2009
Recent ecological studies in invertebrates show that the outcome of an infection is dependent on the specific pairing of host and parasite. Such specificity contrasts the long-held view that invertebrate innate immunity depends on a broadspectrum ...
Carolyn Riddell, Riddell, Carolyn, Eamonn B. Mallon (7514327), Adams, Sally, Sally Adams, Schmid-Hempel, Paul, Mallon Eamonn B., Schmid-Hempel Paul, Carolyn Riddell (257705), Paul Schmid-Hempel, S. Adams (1469704), Mallon, Eamonn B., Eamonn B Mallon, Adams Sally, Riddell Carolyn, Ridell, Carolyn, P. Schmid-Hempel (7607216)   +16 more
core   +1 more source

The Conserved ESCRT-III Machinery Participates in the Phagocytosis of Entamoeba histolytica

Frontiers in Cellular and Infection Microbiology, 2018
The endosomal sorting complex required for transport (ESCRT) orchestrates cell membrane-remodeling mechanisms in eukaryotes, including endocytosis. However, ESCRT functions in phagocytosis (ingestion of ≥250 nm particles), has been poorly studied.
Yunuen Avalos-Padilla, Yunuen Avalos-Padilla, Roland L. Knorr, Rosario Javier-Reyna, Guillermina García-Rivera, Reinhard Lipowsky, Rumiana Dimova, Esther Orozco   +7 more
doaj   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

The Pathogenesis of Human Cervical Epithelium Cells Induced by Interacting with Trichomonas vaginalis. [PDF]

PLoS ONE, 2015
Trichomonas vaginalis is a protozoan parasite that occurs in the urogenital-vaginal tract and is the primary causative agent of trichomoniasis, a common sexually transmitted disease in humans. The aggregation of this protozoan tends to destroy epithelial
Wei-Chen Lin, Wei-Ting Chang, Tsuey-Yu Chang, Jyh-Wei Shin   +3 more
doaj   +1 more source

Alba protein-mediated gene and protein regulation in protozoan parasites

International Journal for Parasitology
The success of protozoan parasites relies heavily on regulation of gene and protein expression to facilitate their persistence in harsh and often changing environments. These parasites display biology that is highly divergent from model eukaryotes, unfortunately leaving our understanding of these parasites' critical regulatory mechanisms incomplete ...
Meghan E, Zadow, Christopher A, MacRaild, Darren J, Creek, Danny W, Wilson   +3 more
openaire   +2 more sources

Glycosylated proteins in the protozoan algaEuglena gracilis: a proteomic approach

FEMS Microbiology Letters, 2022
AbstractProtein glycosylation, and in particular N-linked glycans, is a hallmark of eukaryotic cells and has been well-studied in mammalian cells and parasites. However, little research has been conducted to investigate the conservation and variation of protein glycosylation pathways in other eukaryotic organisms.
openaire   +2 more sources

Rumen methanogenic archaea and their correlation with enteric methane emission in ruminant animals: A systematic review and meta‐analysis

JSFA reports, EarlyView.
Abstract Background Livestock, especially ruminants, are a major source of global methane emissions, primarily produced by methanogenic archaea during enteric fermentation. We performed a systematic review and meta‐analysis to account for factors that could influence the relationship between ruminal methanogenic populations and methane emissions, such ...
Arlan Araujo Rodrigues, Igor Machado Ferreira, Fiorella Viquez Umana, Juliana Silva de Oliveira, Hilario C. Mantovani   +4 more
wiley   +1 more source

Unique posttranslational modifications in eukaryotic translation factors and their roles in protozoan parasite viability and pathogenesis.

, 2013
Protozoan parasites are one of the major causes of diseases worldwide. The vector transmitted parasites exhibit complex life cycles involving interactions between humans, protozoa, and arthropods.
Bütikofer, Peter, Subramanian, Gowri, Madhubala, Rentala, Mittal, Nimisha   +3 more
core   +1 more source