Results 61 to 70 of about 71,120 (247)

Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei

Frontiers in Pharmacology, 2015
Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl ...
Jane Claire Munday, Luca eSettimo, Luca eSettimo, Harry P de Koning   +3 more
doaj   +1 more source

Structural Basis of Parasitic HSP90 ATPase Inhibition by Small Molecules

Pharmaceuticals, 2022
Protozoan parasites are responsible for several harmful and widespread human diseases that cause high morbidity and mortality. Currently available treatments have serious limitations due to poor efficiency, strong adverse effects, and high cost.
Giusy Tassone, Marco Mazzorana, Cecilia Pozzi   +2 more
doaj   +1 more source

The genome of the protozoan parasite Cystoisospora suis and a reverse vaccinology approach to identify vaccine candidates [PDF]

, 2017
Vaccine development targeting protozoan parasites remains challenging, partly due to the complex interactions between these eukaryotes and the host immune system.
Aliaga-Leyton, Altenhoff, Anja Joachim, Aruna Shrestha, Bhopale, Blake, Blake, Blum, Bradford, Burset, Bärbel Ruttkowski, Cantarel, Claus Vogl, Conesa, Cui, Damer P. Blake, de Oliveira Lopes, Dlugonska, Elsheikha, Emanuelsson, Fiona Tomley, Flower, Gabner, Gajria, Gharahdaghi, Goodswen, Goodswen, Goodswen, Goodswen, Hassan, Hehl, Hiszczynska-Sawicka, Horton, Jackson, Jenkins, Jimenez, Joachim, Jones, Jongert, Kall, Kim, Kissinger, Korf, Kurtz, Larsen, Lillehoj, Lim, Lindsay, Loytynoja, Martens, Matrajt, McAllister, Meyer, Min, Monney, Monney, Mortazavi, Mundt, Myhre, Nam, Nicola Palmieri, Nishikawa, Ogedengbe, Parra, Petersen, Pizza, Ramaprasad, Reichel, Samarasinghe, Sato, Schulz, Schwarz, Schwarz, Shevchenko, Shrestha, Sonnhammer, Stanisic, Stanke, Stephen, Templeton, Thorvaldsdottir, Tomas Beck, Trapnell, Williams, Worliczek, Worliczek, Worliczek, Xiang, Zhu   +88 more
core   +2 more sources

The EhCPADH112 complex of Entamoeba histolytica interacts with tight junction proteins occludin and claudin-1 to produce epithelial damage. [PDF]

PLoS ONE, 2013
Entamoeba histolytica, the protozoan responsible for human amoebiasis, causes between 30,000 and 100,000 deaths per year worldwide. Amoebiasis is characterized by intestinal epithelial damage provoking severe diarrhea.
Abigail Betanzos, Rosario Javier-Reyna, Guillermina García-Rivera, Cecilia Bañuelos, Lorenza González-Mariscal, Michael Schnoor, Esther Orozco   +6 more
doaj   +1 more source

Role of Leukotrienes on Protozoan and Helminth Infections

Mediators of Inflammation, 2012
Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities.
Alexandre P. Rogerio, Fernanda F. Anibal
doaj   +1 more source

The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins

Pathogens, 2017
Lipid rafts are liquid-ordered membrane microdomains that form by preferential association of 3-β-hydroxysterols, sphingolipids and raft-associated proteins often having acyl modifications.
Aabha I. Sharma, Cheryl L. Olson, David M. Engman   +2 more
doaj   +1 more source

Comparative Analysis of the Secretome and Interactome of Trypanosoma cruzi and Trypanosoma rangeli Reveals Species Specific Immune Response Modulating Proteins

Frontiers in Immunology, 2020
Chagas disease, a zoonosis caused by the flagellate protozoan Trypanosoma cruzi, is a chronic and systemic parasitic infection that affects ~5–7 million people worldwide, mainly in Latin America. Chagas disease is an emerging public health problem due to
Renata Watanabe Costa, Marina Ferreira Batista, Isabela Meneghelli, Ramon Oliveira Vidal, Ramon Oliveira Vidal, Carlos Alcides Nájera, Ana Clara Mendes, Izabela Augusta Andrade-Lima, José Franco da Silveira, Luciano Rodrigo Lopes, Ludmila Rodrigues Pinto Ferreira, Fernando Antoneli, Diana Bahia, Diana Bahia   +13 more
doaj   +1 more source

The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host [PDF]

, 2013
Bardet–Biedl syndrome (BBS) is a human genetic disorder with a spectrum of symptoms caused by primary cilium dysfunction. The disease is caused by mutations in one of at least 17 identified genes, of which seven encode subunits of the BBSome, a protein ...
Doehl, Johannes, Farrant, Katie, Hodgkinson, Michael R., Paape, Daniel, Price, Helen P., Smith, Deborah F., Stark, Meg   +6 more
core   +1 more source

Technobiological Pathways for High‐CO₂ Capture Using Micro‐/Macroalgae: Genetic Engineering, Process Automation, and Value‐Added Bioproducts

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Greenhouse gas (GHG) emissions have emerged as one of the most critical drivers of climate change; this is primarily due to high concentrations and long atmospheric life of carbon dioxide (CO2). For a significant amount of time, various biological processes such as microalgal cultivation, cyanobacterial systems, photosynthetic microorganisms ...
Sadhana Semwal, Harish Chandra Joshi
wiley   +1 more source

Plasmodium falciparum Molecular Chaperones: Guardians of the Malaria Parasite Proteome and Renovators of the Host Proteome

Frontiers in Cell and Developmental Biology, 2022
Plasmodium falciparum is a unicellular protozoan parasite and causative agent of the most severe form of malaria in humans. The malaria parasite has had to develop sophisticated mechanisms to preserve its proteome under the changing stressful conditions ...
Gregory L. Blatch, Gregory L. Blatch, Gregory L. Blatch   +2 more
doaj   +1 more source