Results 71 to 80 of about 45,570 (245)

Unraveling the relevance of the polyadenylation factor EhCFIm25 in Entamoeba histolytica through proteomic analysis

FEBS Open Bio, 2021
We recently reported that silencing of the polyadenylation factor EhCFIm25 in Entamoeba histolytica, the protozoan which causes human amoebiasis, affects trophozoite proliferation, death, and virulence, suggesting that EhCFIm25 may have potential as a ...
América Itzallana Salgado‐Martínez, Rodolfo Gamaliel Avila‐Bonilla, Esther Ramírez‐Moreno, Carlos Alberto Castañón‐Sánchez, César López‐Camarillo, Laurence A. Marchat   +5 more
doaj   +1 more source

Microbial communities and functional diversity in seafood

JSFA reports, EarlyView.
Abstract Functional diversity encompasses ecosystem processes that enhance adaptability to environmental change. This study explores the diversity of microorganisms associated with seafood. In this paper, we present our knowledge of microbial diversity in relation to seafood.
Christian Larbi Ayisi, Samuel Ayeh Osei, Grace Afumwaa Boamah, Gertrude Dzifa Mensah   +3 more
wiley   +1 more source

Inhibition of apoptosis by intracellular protozoan parasites

, 2001
Protozoan parasites which reside inside a host cell avoid direct destruction by the immune system of the host. The infected cell, however, still has the capacity to counteract the invasive pathogen by initiating its own death, a process which is called ...
Küenzi, P, Rottenberg, S, Heussler, Volker   +2 more
core   +1 more source

Heat shock protein 90 from neglected protozoan parasites

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012
Significant advances have been made in our understanding of heat shock protein 90 (Hsp90) in terms of its structure, biochemical characteristics, post-translational modifications, interactomes, regulation and functions. In addition to yeast as a model several new systems have now been examined including flies, worms, plants as well as mammalian cells ...
Roy, Nainita, Nageshan, Rishi Kumar, Ranade, Shatakshi, Tatu, Utpal   +3 more
openaire   +3 more sources

The modified base J is the target for a novelDNA-binding protein in kinetoplastid protozoans [PDF]

The EMBO Journal, 1999
DNA from Kinetoplastida contains the unusual modified base beta-D-glucosyl(hydroxymethyl)uracil, called J. Base J is found predominantly in repetitive DNA and correlates with epigenetic silencing of telomeric variant surface glycoprotein genes in Trypanosoma brucei. We have now identified a protein in nuclear extracts of bloodstream stage T.brucei that
Cross, Mike, Kieft, Rudo, Sabatini, Robert, Wilm, Matthias, de Kort, Martin, van der Marel, Gijs A., van Boom, Jacques H., van Leeuwen, Fred, Borst, Piet   +8 more
openaire   +2 more sources

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

PROTOGIM: a novel tool to search motifs and domains in hypothetical proteins of protozoan genomes.

, 2006
peer reviewedWhole sequencing of protozoan trypanosomatid genomes revealed the presence of several predicted unknown genes coding for hypothetical proteins.
Haver, Nicolaas J., Ramirez, Marcel I., Cestari, Igor S., BARBOSA DA SILVA, Adriano   +3 more
core   +1 more source

The role of surface glycoconjugates in Leishmania midgut attachment examined by competitive binding assays and experimental development in sand flies [PDF]

, 2013
SUMMARY Binding of promastigotes to the sand fly midgut epithelium is regarded as an essential part of the Leishmania life cycle in the vector. Among Leishmania surface molecules putatively involved in attachment to the sand fly midgut, two GPI-anchored ...
Jecna, Lucie, Bates, Paul A., Seblova, Veronika, Volf, Petr, Dostalova, Anna, Chang, Kwang-Poo, LUCIE JECNA, VERONIKA SEBLOVA, PAUL A. BATES, PETR VOLF, ANNA DOSTALOVA, RAY WILSON, Wilson, Ray, KWANG-POO CHANG   +13 more
core   +1 more source

Host-specific targets of Histomonas meleagridis antigens revealed by immunoprecipitation

Scientific Reports
Histomonas meleagridis, a protozoan parasite responsible for histomonosis (syn. Blackhead disease, histomoniasis), presents an increasing challenge for poultry health, particularly with the ban of licensed prophylactic and treatment options.
Marcelo de Jesus Ramires, Karin Hummel, Tamas Hatfaludi, Michael Hess, Ivana Bilic   +4 more
doaj   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source