Results 11 to 20 of about 45,570 (245)
A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes. [PDF]
PLoS Neglected Tropical Diseases, 2014 Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Brendan D Galvin +7 more
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Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites [PDF]
Parasites & Vectors, 2011 Apoptosis-like programmed cell death (PCD) has recently been described in multiple taxa of unicellular protists, including the protozoan parasites Plasmodium, Trypanosoma and Leishmania.
Reece Sarah E +2 more
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Identification of putative potassium channel homologues in pathogenic protozoa. [PDF]
PLoS ONE, 2012 K(+) channels play a vital homeostatic role in cells and abnormal activity of these channels can dramatically alter cell function and survival, suggesting that they might be attractive drug targets in pathogenic organisms.
David L Prole, Neil V Marrion
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Role of Leukotrienes on Protozoan and Helminth Infections [PDF]
Mediators of Inflammation, 2012 Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities.
Alexandre P. Rogerio, Fernanda F. Anibal
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Production of recombinant proteins from protozoan parasites [PDF]
Trends in Parasitology, 2010 Although the past decade has witnessed sequencing from an increasing number of parasites, modern high-throughput DNA sequencing technologies have the potential to generate complete genome sequences at even higher rates. Along with the discovery of genes that might constitute potential targets for chemotherapy or vaccination, the need for novel protein ...
José A, Fernández-Robledo +1 more
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Role of Host Small GTPases in Apicomplexan Parasite Infection
Microorganisms, 2022 The Apicomplexa are obligate intracellular parasites responsible for several important human diseases. These protozoan organisms have evolved several strategies to modify the host cell environment to create a favorable niche for their survival.
Silvio Paone, Anna Olivieri
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Cysteine proteases in protozoan parasites. [PDF]
PLoS Neglected Tropical Diseases, 2018 Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites, including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or modulation of the host immune response, making them attractive ...
Jair L Siqueira-Neto +6 more
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Released Parasite-Derived Kinases as Novel Targets for Antiparasitic Therapies
Frontiers in Cellular and Infection Microbiology, 2022 The efficient manipulation of their host cell is an essential feature of intracellular parasites. Most molecular mechanisms governing the subversion of host cell by protozoan parasites involve the release of parasite-derived molecules into the host cell ...
Anne Silvestre +3 more
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Protein arginine methyltransferases in protozoan parasites
Parasitology, 2021 AbstractArginine methylation is a post-translational modification involved in gene transcription, signalling pathways, DNA repair, RNA metabolism and splicing, among others, mechanisms that in protozoa parasites may be involved in pathogenicity-related events.
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Genomic Databases and the Search of Protein Targets for Protozoan Parasites [PDF]
Current Drug Targets, 2009 The development of databases devoted to biological information opened the possibility to integrate, query and analyze biological data obtained from several sources that otherwise would be scattered through the web. Several issues arise in the handling of biological information, mainly due to the diversity of biological subject matter and the complexity
Luís Fernando S M, Timmers +6 more
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