Biosynthesis and biology of mammalian GPI-anchored proteins [PDF]
Open Biology, 2020 At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs). The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma membrane with GPI covalently attached to the C-terminus.
Taroh Kinoshita
doaj +1 more source
Rescue of Glycosylphosphatidylinositol-Anchored Protein Biosynthesis Using Synthetic Glycosylphosphatidylinositol Oligosaccharides [PDF]
ACS Chemical Biology, 2021 The attachment of proteins to the cell membrane using a glycosylphosphatidylinositol (GPI) anchor is a ubiquitous process in eukaryotic cells. Deficiencies in the biosynthesis of GPIs and the concomitant production of GPI-anchored proteins lead to a series of rare and complicated disorders associated with inherited GPI deficiencies (IGDs) in humans ...
Paula A. Guerrero +5 more
openaire +3 more sources
Glycosylphosphatidylinositol-Anchor Synthesis in Plants: A Glycobiology Perspective
Frontiers in Plant Science, 2020 More than 200 diverse secretory proteins from Arabidopsis thaliana carry a glycosylphosphatidylinositol (GPI) lipid anchor covalently attached to their carboxyl-terminus.
Gernot Beihammer +3 more
doaj +1 more source
Turnover of Variant Surface Glycoprotein in
mBio, 2021 African trypanosomes utilize glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) to evade the host immune system. VSG turnover is thought to be mediated via cleavage of the GPI anchor by endogenous GPI-specific phospholipase C (
Paige Garrison +9 more
doaj +1 more source
GPI-AP: Unraveling a New Class of Malignancy Mediators and Potential Immunotherapy Targets
Frontiers in Oncology, 2020 With millions of cases diagnosed annually and high economic burden to cover expensive costs, cancer is one of the most difficult diseases to treat due to late diagnosis and severe adverse effects from conventional therapy.
Nada H. Hussein +2 more
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Trypanosome Glycosylphosphatidylinositol Biosynthesis [PDF]
The Korean Journal of Parasitology, 2009 Trypanosoma brucei, a protozoan parasite, causes sleeping sickness in humans and Nagana disease in domestic animals in central Africa. The trypanosome surface is extensively covered by glycosylphosphatidylinositol (GPI)-anchored proteins known as variant surface glycoproteins and procyclins.
Yeonchul, Hong, Taroh, Kinoshita
openaire +2 more sources
New Players in Neuronal Iron Homeostasis: Insights from CRISPRi Studies
Antioxidants, 2022 Selective regional iron accumulation is a hallmark of several neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. The underlying mechanisms of neuronal iron dyshomeostasis have been studied, mainly in a gene-by-gene ...
Daniel A. Bórquez +3 more
doaj +1 more source
Major Surface Antigens in Zoonotic Babesia
Pathogens, 2022 Human babesiosis results from a combination of tick tropism for humans, susceptibility of a host to sustain Babesia development, and contact with infected ticks.
Stephane Delbecq
doaj +1 more source
A proteomic analysis of lipid raft and GPI anchored proteins in Caenorhabditis elegans [PDF]
, 2010 Glycosylphosphatidylinositol (GPI) anchored proteins are a unique group of membrane proteins found on the surface and certain intracellular compartments of eukaryotic cells.
Rao, Wei
core +5 more sources
Probing Trypanosoma brucei glycosylphosphatidylinositol biosynthesis using novel precursor-analogues
, 2008 Glycosylphosphatidylinositol precursor-analogues were synthesized in which the natural diacylglycerol lipid was replaced with either of two steroidal moieties.
Crossman, Arthur +2 more
core +5 more sources